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Draft Programme
Innate Immune Memory
18-20 March 2015
Kendrew Lecture Theatre, EBI South Building,
Wellcome Trust Genome Campus,
Hinxton, Cambridge, UK
Oral Presentations
All presenters are requested to give an electronic version of their presentation to the AV
technician in advance.
Poster Presentations
Posters will be displayed throughout the conference in the Chestnut Suite. Poster numbers
will be assigned during registration.
Wednesday, 18 March
12:30-13:45
Registration with buffet lunch
Conference Centre Foyer
13:45-14:00
Walk to the Kendrew Lecture Theatre
Led by the Wellcome Trust Scientific Conferences team
14:00-14:10
Welcome and Introduction
Mihai Netea
14:10-15:00
Keynote Lecture:
The role of the NLRP3 inflammasome in Alzheimer's disease
Douglas Golenbock
University of Massachusetts Medical School, USA
15:00-16:00
Session 1: Concepts in innate immune memory
Chair: Luke O’Neill
15:00 Trained immunity: a memory for the innate immune responses
Mihai Netea,
University Nijmegen Medical Center, The Netherlands
15:30 The macrophage epigenome and the control of basal and
inducible gene expression
Gioachinno Natoli
IFOM-IEO Campus, Italy
16:00-16:30
Afternoon Tea
Kendrew Lecture Theatre Foyer
16:30-18:00
Session 1 continued: Concepts in innate immune memory
Chair: Luke O’Neill
16:30 Microbial programming of macrophage function during
myelopoiesis
Helen Goodridge
Cedars-Sinai Medical Center, USA
17:00 Reprogramming of macrophages in atherosclerosis
Eicke Latz
University of Bonn, Germany
17:30 The innate immune system favors emergency monopoiesis at
the expense of DC differentiation to control bacterial infections
Kristin Bieber
University Hospital of Tübingen, Germany
17:45 Impact of a hypercholesterolemic environment on innate
immune cells – induction of a trained memory?
Anette Christ
University of Massachusetts Medical School, USA
18:00-19:30
Poster Session I (odd numbers) with Drinks Reception
Chestnut Suite
19:30
Dinner
Hall Restaurant
Thursday, 19 March
09:00-10:30
Session 2: Infection and Vaccination
Chair: Kingston Mills
09:00 A small jab – a big effect: nonspecific immunomodulation by
vaccines
Christine Stabell Benn
Statens Serum Institut, Denmark
09:30 The role of immune modulators in the treatment of cancer
Angus Dalgleish
St George’s University of London, UK
10:00 BCG-Vaccination enhances immunogenicity of subsequent
influenza vaccination in healthy volunteers: a randomized
placebo-controlled double-blind pilot study
Jenneke Leentjens
Radboud University Medical Center, The Netherlands
10:15 Trainable anti-inflammatory effects of live attenuated pertussis
vaccine
Camille Locht
INSERM, France
10:30 -11:00
Morning Coffee
Kendrew Lecture Theatre Foyer
11:00 -12:30
Session 2 continued: Infection and Vaccination
Chair: Kingston Mills
11:00 Systems-based approaches to vaccine development
Bali Pulendran
Emory University, USA
11:30 Immune regulation at barrier surfaces
David Artis
Weil Cornell Medical College, New York, USA
12:00 Innate lymphoid cell (ILC) distribution and function after BCG
vaccination of mice
Joanna Kirman
University of Otago, New Zealand
12:15 Enhancement of pathogen-specific natural killer cell ‘memory’
by removal of a viral innate immune signalling inhibitor
Hongwei Ren
University of Cambridge, United Kingdom
12:30-14:00
Lunch
Hall Restaurant
14:00-15:30
Session 3: Disease
Chair: Mihai Netea
14:00 A Sirtuin family partnership guards immunometabolic
homeostasis during acute inflammation: a route to novel
therapeutics
Charles McCall
Wake Forest School of Medicine, USA
14:30 Fate decisions in IL-17 and IL-22 producing T cells
Birgitta Stockinger
National Institute for Medical Research, UK
15:00 Regulatory and pathogenic roles of innate immune cells in
autoimmune diseases
Kingston Mills
Trinity College Dublin, Ireland
15:30-16:00
Afternoon Tea
Kendrew Lecture Theatre Foyer
16:00-17:30
Session 3 continued: Disease
Chair: Mihai Netea
16:00 Towards an epigenetic memory of infection: bacteria-induced
chromatin modifications
Melanie Hamon
Institut Pasteur, France
16:30 Genotype-phenotype relationships provide clues to immune
function
Ramnik Xavier
Harvard Medical School, USA
17:00 Human cytokine-induced memory-like (CIML) NK cells are
active against myeloid leukemia in vitro and in vivo
Maximillian Rosario
Washington University School of Medicine, USA
17:15 Clinical proof-of-concept of TLR 7, 8, and 9 antagonism in
patients with moderate-to-severe plaque psoriasis
Sudhir Agrawal
Idera Pharmaceuticals, USA
17:30-19:00
Poster Session II (even numbers) with drinks reception
Chestnut Suite
19:00
Conference Dinner
Hall Restaurant
Friday, 20 March
09:00-10:30
Session 4: Mechanisms of innate immune memory
Chair: Eicke Latz
09:00 Long non-coding RNAs; new players in regulation of
inflammatory gene expression
Kate Fitzgerald
University of Massachusetts Medical School, USA
09:30 Development of long-lived macrophage phenotype during
helminth infection
William Gause
Rutgers New Jersey Medical School, USA
10:00 Adaptation of innate barrier immunity in response to nutrition
Christoph Wilhelm
NIH, USA
10:15 S. cerevisiae chitin drives trained immunity during cross-talk
with microbiota
Lisa Rizzetto
Fondazione Edmund Mach, Italy
10:30-11:00
Morning Coffee
Kendrew Lecture Theatre Foyer
11:00-12:30
Session 4 continued: Mechanisms of innate immune memory
Chair: Eicke Latz
11:00 Lymphocyte Genomic Switches and Acquisition of Cell Identity
and Function
John O’Shea
NIH, USA
11:30 Long term in vivo inflammatory suppression of microglia by
LPS-preconditioning is mediated by epigenetic silencing
Bart Eggen
University of Groningen, The Netherlands
11:45 Long-term modulation of microglial immune responses after
short-term peripheral immune stimulation
Jonas Neher
German Centre for Neurodegenerative Disease, Germany
12:00 Metabolic reprogramming in innate immunity
Luke O’Neill
Trinity College Dublin, Ireland
12:30
Closing remarks, prize announcements and conference summary
Luke O’Neill
13:00-14:00
Lunch
Hall Restaurant
14:00
Coaches depart to Cambridge and Heathrow Airport via Stansted
Airport
Outside the Conference Centre Reception