NANOTECHNOLOGY IN MEDICINE СЕМ®-ТЕСН Apparatus – An Effective Supplement to Traditional Therapies: • When there is a risk of polypharmacy in a patient with several conditions. • For patients with chronic conditions. • When a patient is experiencing complications and side effects from pharmacological treatment. • When traditional treatment methods do not yield effective results. • For patients with drug resistance or intolerance. • When there are contraindications against other treatment methods. Advantages of using the СЕМ®-ТЕСН Apparatus: 1. Several methods for treating a wide range of diseases: • EHF therapy — extremely high frequency electromagnetic radiation in single-frequency mode or using selected noise-like mode; • IR therapy — infrared radiation; • BRR therapy — using background resonance radiation. 2. Compact, with independent power supply. 3. Corresponding to physiotherapeutic methods which are connected with use low intensive sources of electromagnetic radiation. 4. Complements other treatment methods. СЕМ®-therapy — therapy with the СЕМ®-ТЕСН apparatus uses EHF therapy followed by treatment in BRR mode. СЕМ®-therapy: • • • • • Reduces any type of pain, reduces inflammation at pathological sites. Cuts the duration of standard treatment for a wide array of diseases. Expands options for out-patient and at-home rehabilitation. Offers tools for primary and secondary prevention. Increase the effectiveness of pharmacological therapy while reducing and in some cases even eliminating dosages. Clinical researches confirm good shipping EHF-therapies, absence of complications and by-effects, including at long supervision over the treated patients up to two years after treatment. 1 NANOTECHNOLOGY IN MEDICINE Extremely high frequencies (EHF) are in the range of 30—300 GHz (with wavelengths of 10-1 mm). EHF causes frequency resonance in biological organisms, and therapeutic efficacy is observed at radiation levels much lower than those found in other ranges. This can be explained by a lack of adaptation to this specific type of cosmic radiation, which is trapped by the atmosphere, as well as by the signal’s close resemblance to the body’s own electromagnetic waves. What sets the СЕМ®-ТЕСН apparatus apart from other EHF therapies is its option of using BRR mode, which operates according to the homeopathic principle of like curing like. And like homeopathy, BRR mode is non-intensive. Background resonance radiation therapy (BRR) is based on the use of memory materials that create a spectral copy of the radiation emitted by the cells of living organisms in the EHF range and cause its automatic retransmission (Gunn diode). By influencing the frequency resonances of cell structures, pathological processes can be weakened or blocked entirely, at the same time amplifying physiological oscillations and restoring dynamic equilibrium in the patient’s body. When applied to human skin, EHF radiation penetrates to a depth of 300—500 microns, meaning that it is almost entirely absorbed by the epidermis and upper layers of the dermis. СЕМ® — Controlled Energy Material Technology With its direct effects targeted at nerve receptors, the capillary bed, skin depositories of leukocytes and cells of the diffuse neuro-endocrine system, the therapeutic action of EHF therapy is directed at: • the nervous system; • the immune system and phagocytes; • blood aggregate state regulators (coagulatory and anti-coagulatory mechanisms); • humoral regulation. So EHF therapy is effective in treating a wide array of diseases. 2 NANOTECHNOLOGY IN MEDICINE Methods for using the СЕМ®-ТЕСН apparatus: 1) EHF and IR radiation can be applied to a pathological site, reflexogenic zones and/or bioactive points on the body using interchangeable emitters with various modulating frequencies and radiation spectrum (the apparatus is programmed to work on each zone or point for 10 minutes); 2) BRR mode: When the emitter is applied to the pathological site, its dipole-active mode is adjusted over the course of one minute, after which it switches to automatic retransmission at the same zone (at this point the emitter is fixed to the patient). The number of times this processes is repeated depends on the acuteness of the disease process, from hourly applications for acute cases to once-daily applications for chronic conditions. A round of therapy usually involves daily procedures performed for 5 to 10 days. Key indications for using EHF therapy: • • • • • • • Initial presentation of acute viral respiratory infections. Pain syndrome at any location. Joint and spine conditions. Wounds, hematomas, burns. Allergies and skin conditions. Cardiovascular disease. Disease of reproduction system. These methods for using the СЕМ®-ТЕСН apparatus have been approved by the Russian Ministry of Health. The quality assurance system under which the apparatus is manufactured is certified for conformance to European Union standards. EHF therapy should NOT be used in the following instances: • • • • For patients without a positive diagnosis. For patients with individual intolerance to the therapy. For pregnant patients. For patients with implant devices with independent power supply, such as artificial pacemakers. EHF therapy has a mild sedative effect that may cause drowsiness and reduced attention in patients with heightened sensitivity to EHF radiation. In such cases, it is advisable to avoid performing work that requires concentration, including driving a vehicle, immediately after the procedure. For safety purposes, the procedure may be carried out before bedtime. The СЕМ®-ТЕСН apparatus has been successfully demonstrated at trade shows in Russia and around the world. The device has received a number of awards, including: Gold Medal at EWEI, Sofia, Bulgaria; Silver Medal at Eureka, Brussels, Belgium, 2001; Silver Medal at INPEX, Pittsburgh, PA, 2001; Gold Medal at VDNKh, Moscow, Russia, 2003. You must to have the consultation of the doctor before the treatment. 3 NANOTECHNOLOGY IN MEDICINE СЕМ®-ТЕСН Patents: 1. RF Patent of Invention 2281129 “Portable pulse apparatus for electrotherapy,” date of priority October 15, 2004. 2. U.S. patent 6122550 “Device for therapeutic action on human organism,” date of priority September 19, 2000. 3. Certificate of Trademark 306040 for “СЕМ ТЕСН СЕМ ТЕХ,” date of priority February 07, 2005. 4. Certificate of Trademark 351257 for “СЕМ ТЕСН СЕМ ТЕХ,” date of priority May 15, 2006. 5. Certificate of Trademark 348805 for “СЕМ ТЕСН СЕМ ТЕХ,” date of priority March 20, 2007. 6. Certificate of European Trademark 989300 for “СЕМ ТЕСН СЕМ ТЕХ”. 7. Certificate of Trademark 344494 for “BRR Therapy,” date of priority August 10, 2006. 8. International application for patent of invention “Device for regulating physiological processes in a biological object” РСТ/RU2008/000282, Patent 2341851. 9. Useful model “Connecting and fastening mechanism,” Patent 76786, date of priority May 07, 2008. 10.Design Application 2008500403 “Apparatus for physical therapy”. 11.International Trademark Application for “СЕМ ТЕСН СЕМ ТЕХ”. 12.Application for Patent 2008127927 “Method for increasing resistivity of biological objects”. 13. Application for Patent 2008138337 “Method of protection from the negative effects of radiation from cell phone and wireless phone”. 14. Useful Model Application 2008138260 “Wireless telephone”. CJSC CEM Technology and LLC Spinor are performing the following joint research projects with support from the Foundation for Supporting Small Businesses in the Field of Science and Technology: • START-2004 “Design for a new method of prevention and treatment of infectious diseases using controlled energy material technology”. • START-2005 “Design for a new method of rehabilitation for psychological and emotional disorders and a portable physiopuncture apparatus for individual use with the rehabilitation method”. • START-2006 “Design for a new method of prevention and treatment of infectious and inflammatory diseases of oral organs and tissues”. • START-2008 “Group of devices for protecting industrial materials from microbiological damage”. 4 List of Studied Results of the Application of EHF and BRR Therapy: Clinical Condition Result of EHF Therapy Neurology Cerebral atherosclerosis Normalized cerebral circulation and lipid exchange indicators Headache Significant reduction in pain intensity and duration of episodes Vertebrobasilar insufficiency Elimination or significant reduction in head pain and dizziness Neurological symptoms of degenera- Significant pain reduction, increased pain threshold tive spine disease, including disk syn- in local algogenic zones drome Thermographic picture of degenerative disease of the cervicothoracic vertebrae Normalized thermographic picture after EHF therapy Pediatric scoliosis Significant pain reduction, increased tolerance of phy sical exertion, increased amplitude of spine motion Exogenic-organic brain damage (of a Elimination of asthenic symptoms, mood swings, hytraumatic, vascular, infectious/toxic peresthesia, headaches, dizziness, arterial blood presand combined nature) sure fluctuations, nighttime sleep restoration Mono- and polyneuropathy Pain reduction, increased speed of nerve impulse conduction Vegetative disorders, including vege Normalized vegetative condition, reduction or elimitative crises (panic attacks) nation of headaches, improved hemodynamics based on rheography 5 Clinical Condition Result of EHF Therapy Post-traumatic and stress disorders – Reduction or elimination of irritability, mood swings treatment and prevention and sleep disorders; improved mood and work capacity Infantile cerebral palsy Reduced muscle tone, increased mobility level Epilepsy, including drug-resistant Reduction in the number of seizures and positive dynamic in EEG picture Pulmonology Thermographic picture of left-side pneumonia Pneumonia Normalized thermographic picture after EHF therapy Chronic nonobstructive bronchitis Increased effectiveness of treatment, reduced duration of treatment, prevention of lingering illness Anti-inflammatory effect Chronic obstructive bronchitis Relief of broncho-obstructive syndrome Sarcoidosis of the lungs and intratho- Normalized x-ray and immunogram picture, norma racic lymph nodes lized respiratory function, reduced frequency of aggravation and recurrence Bronchial asthma Reduced coughing and shortness of breath, reduced need for inhaled bronchial spasmolytic, improved mucus discharge, normalized respiratory function, immunomodulatory effect Vascular Diseases Obliterative atherosclerosis of the ar- Elimination of pain syndrome, reduction of intermitteries of the lower limb tent lameness Obliterative endarteritis Elimination of pain syndrome, reduction of intermittent lameness Raynaud’s disease Improved peripheral circulation and microcirculation Post-thrombotic syndrome Miscarriage 6 Elimination of pain syndrome, faster healing of trophic ulcers Increased duration of the luteal phase of the menstrual cycle, increased levels of estradiol and progesterone, elimination of the need for hormone therapy Clinical Condition Result of EHF Therapy Postabortal complications Immunomodulatory effect, reduction of inflammatory complications Chronic inflammation of the fallo- Pain-relieving effect, softening of adhesive structures, pian tubes, including impaired repro- restored reproductive function ductive function Arthropathy Degenerative and dystrophic ar- Anti-inflammatory effect, increased muscle strength, thropathy (deformative osteoarthri- range of motion in affected joint and tolerance of tis, psoriatic osteoarthropathy) physical exertion Thermographic picture of right knee arthritis Improved thermographic picture with EHF therapy Hemarthrosis and hemophilic joints Pain-relieving effect, normalized hemostasis Rheumatoid arthritis Significant reduction of pain and morning joint stiffness, immunomodulatory effect Surgical Pathology 7 Clinical Condition Result of EHF Therapy Traumatic and post-operative damage to skin, soft tissue and bone tissue, including complications due to infection and slow healing Shortening of all phases of the wound process, antiinflammatory effect, promotion of regeneration, including of bone tissue, prevention of infection, significant pain-relieving effect, reduced dosages of painrelieving medications Pain-relieving effect, fast generation of granulation tissue and epithelialization Reduced duration of the exudative phase of inflammation and stimulation of regenerative processes Pain-relieving effect, normalization of microcirculation and trophic disturbances, restoration of normal range of motion Anti-inflammatory effect Burns Post-traumatic osteomyelitis Post-traumatic stiffness Acute choleocystitis Acute pancreatitis Reduced duration of treatment, positive effect on immune system condition Gastroenterology Ulcer of the stomach and duodenum, including bleeding complications, perforation or penetration Functional incompetence of bile passages Reduced duration of epithelialization of ulcer area, reduced frequency of recurrence Faster and more effective relief of pain and dyspepsia, reduced symptoms of bile inspissations and crystallization, normalized gallbladder contraction Chronic gastroduodenitis, including Faster and more effective relief of pain and dyspepsia infection by Helicobacter pilori Chronic pancreatitis Effective pain relief, restored pancreas function Dermatology 8 Clinical Condition Psoriasis Result of EHF Therapy Atypical dermatitis Anti-inflammatory and regenerative effect, resorption of infiltration, reduced duration of treatment, reduced frequency of recurrence Anti-inflammatory, analgesic and regenerative effect, reduced duration of treatment, faster epithelialization of ulcer area Anti-allergic effect, elimination of itching Microbial eczema Faster healing Acne Faster healing Neurodermatitis Reduced skin itching Vitiligo Restored pigmentation Herpes Significant analgesic and anti-inflammatory effects Syphilis Immunomodulatory effect, faster return of negative serological responses Trophic ulcers Infectious and Parasitic Diseases Chronic opisthorchiasis Improved gallbladder contraction, disappearance of Opisthorchis eggs in bile Tuberculosis of the lungs, including Stabilization over the course of tuberculosis of the with Chlamydia or mycoplasmal in- lungs, reduced frequency of post-operative complicafections tions, faster resorption of infiltration, abacillation and closing of decay cavities Tick-borne encephalitis and tick- Increased mobility, reduced intensity of headaches and borne borreliosis arthralgia, normalized sleep, reduced duration of fever and asthenia, increased antibody titer Viral hepatitis Faster healing 9 Clinical Condition Thermographic picture of acute rhinitis Result of EHF Therapy Normalized thermographic picture after EHF therapy Acute respiratory viral infections — Rates of infection cut in half, milder symptoms during prevention and treatment illness, reduced duration of illness, absence of complications Cardiology Coronary heart disease: exertational Significant antianginal effect, reduced number of anangina, unstable angina, myocardial gina attacks, episodes of painless myocardial ischemia infarction, arrythmia and arrythmia, improved diastolic function of the left ventricle, reduced dosage of nitroglycerine, norma lized antithrombin III activity and erythrocyte deformation Arterial hypertension, including hy Hypotensive effect, reduced peripheral resistance, pertonic crises improved cerebral circulation, normalized catecholamine excretion Non-coronary myocardial damage Reduced frequency of cardialgia, normalized hemo(mitral valve prolapse, cardiomyopa- stasis indicators, improved quality of life thy, myocarditis) Eye Conditions Diabetic retinopathy Inflammatory eye diseases 10 Improved electro-oculogram indicators, elimination of unpleasant sensations in the eye Elimination of itching, antiallergic effect Clinical Condition Result of EHF Therapy Degenerative diseases of the retina Improved vision sharpness, improved field of vision, and optic nerve improved microcirculation Oral Medicine Adentia and use of prosthodontics Significant anti-inflammatory effect Gingivitis Significant anti-inflammatory effect Periodontal disease Significant anti-inflammatory effect, stimulated regeneration, normalized local circulation in periodontal disease Thermographic picture of submaxillary lymphadenopathy Improved thermographic picture with EHF therapy Submaxillary lymph node after tooth Significant anti-inflammatory effect extraction Andrology Andropause disturbances Increased sex drive, improved sexual function Benign prostatic hyperplasia Increased sex drive, improved sexual function Chronic prostatitis Relief of pain and dysuric symptoms, improved sexual function Secretory and toxic infertility Stimulation of spermatogenesis Endocrinology Grave’s disease Reduced size of thyroid, change in its texture 11 Clinical Condition Nodular goiter Result of EHF Therapy Elimination or reduction in the size of solitary nodes Diabetes and its complications (mi- Regression of complications, stabilization of disease cro- and macroangiopathy, hepato- course, reduced need for insulin sis, cataracts, nephropathy) Liver Disease Cirrhosis Normalized biochemical indicators and liver size and structure Chronic hepatitis Normalized biochemical indicators and liver size and structure Hepatosis Normalized biochemical indicators and liver size and structure Toxic liver damage Normalized biochemical indicators and liver size and structure Chemical Dependency Chronic alcoholism Reduced psychological strain, anxiety, desire for alcohol Substance abuse Positive effect on psychological, emotional and soma tic aspects Oncology Malignant neoplasms (including co- Reduction of the number and degree of polychemolon and rectal cancer, skin melanoma, therapy complications, reducing the frequency of restomach cancer, mammary tumors, currence and metastasis, pain-relieving effect lung cancer, ovarian cancer, cancer of the ENT organs) Bening ovarian tumors Normalization of sex hormone secretion and immune condition Uterine fibroids Reduction of fibroid size Lymphomas (lymphogranulomatosis Activation of body’s antioxidant defenses, suppression and non-Hodgkin lymphomas) of free radical oxidation and normalization of proinflammatory cytokine levels Benign mammary tumors 12 Prevention of malignant change NANOTECHNOLOGY IN MEDICINE *Data taken from guidelines approved by the Russian Ministry of Health and clinical studies performed and analyzed during the process of certifying the СЕМ®-ТЕСН apparatus in countries of the European Union. The studies describe completed prospective controlled studies of EHF therapy for various conditions performed according to the criteria of evidence based medicine. Control groups were given standard treatment. Treatment of the primary groups of patients included EHF therapy. Complete information on clinical studies carried out using the СЕМ®-ТЕСН apparatus can be found at www.spinor.ru. 13 NANOTECHNOLOGY IN MEDICINE EHF Therapy Offers the Following Solutions in Oncology: 2. 3. 4. 5. 6. 7. 8. 1. Prepare cancer patients with the most common localizations for the stages of combined therapy (preparing organs and systems for surgical intervention, radiation damage and aggressive drug regimens). Treat associated conditions and prevent complications. Prevent and treat complications following specialized treatment methods. Treat paraneoplastic syndrome. Improve results of other treatment methods. Palliative care for terminal patients. Systemic correction of environmental and pre-cancerous pathology. Prevent progress of neoplastic process after combined therapy. Proven Mechanisms of Action for EHF and BRR therapy: • Normalization of lipid exchange (reduced concentration of atherogenic fractions and increased high-density lipoprotein content) (Kuz’menko, 1998). • Normalization of the balance of coagulant and anti-coagulant factors (normalization of antithrombin III levels, fibrinolytic potential and thrombocytic hemostasis) (Lopatina N.A. et al., 2003; Bukatko, V.N. 2003). • Normalization of the balance of pro- and anti-oxidant systems (Tumanyants Ye. I., Temuryants N.A., 1997). • Promotion of cell regeneration (enhanced proliferation of fibroblasts) (Polyakova A. G. et al., 1999). • Promotion of hemogenesis in red bone marrow (Lebedeva N. N., Kotrovskaya T. I., 2002). • Normalization of blood flow properties (reduction of blood viscosity, increased erythrocyte elasticity) (Parshina S. S., et al., 2003). • Normalization of immune system functioning (normalization of the number of Т and В-lymphocytes and A, G and M immunoglobulins, normalization of the functioning of neutrophils, restoration of the functioning of В-lymphocytes and leukocyte phagocytic activity) (Shliapak et al., 1996; Bakaliuk et al., 1998; Kuz’menko, 1998; Jin Z., Lin M., Xia J., Zhuang J., Yang R., Li X., et al., 2001; Briskin B. C. and et al, 2003; Bukatko B. N., 2003). • Restoration of the ability of mononuclear phagocytes to secrete interferon gamma, which can reduce incidences of cancer in risk group patients (Sitko S. P. et al., 1993). 14 NANOTECHNOLOGY IN MEDICINE • Anti-inflammatory effect based partly on stimulation of the functioning of phagocytes and regulation of the degranulation of mast cells (Gapeyev A. B., Chemeris N. K., 2007). • Normalization of the secretion of catecholamines and sex hormones (Tsa rev А. А., Kudinova М. А., 1997; Zaporozhan V. N. et al., 1997). • Impact on the endogenous opioid system (Radzievsky et al., 2001), activation of the antinociceptive system (Kirova B. V., 2000). • Normalization of brain electrical activity (stabilized alpha-rhythm, restoration of initially disrupted interzonal and interhemispheric relations of the key EEG rhythms) (Tyshkevich et al., 1998; Gubarec M.Y., 1989; Stolbikov A. E. and et al, 1991). • Normalization of vegetative regulation, stabilization of the balance between the sympathetic and parasympathetic branches of the vegetative nervous system (Dikke G. B., 1999). Thermographic picture of secondary thymic-dependent immunodeficiency Normalized thermographic picture after EHF therapy • Antistressor activity — inhibition of excess activity in the sympathoadrenal system and activation of the stress-limiting systems (Chuyan Ye. N., Temuryants N. А., 2005). • Inhibition of flu virus replication in cells, anti-viral effect (Podchernyaeva R. Ya. et al., 2004). • Cytoprotective effect on red bone marrow and liver in patients receiving polychemotherapy (Kareva N. P. et al., 2006). • Change to the structural and dynamic characteristics of cell membranes (Semina I. G. et al., 2007). • Slowing of aging processes for skin, liver and the central nervous system (Rodshtat I. V., 2007). • Normalization of vascular tone and promotion of microcirculation, normalization of the responsiveness of vascular endothelium (normalized rheogram and rheoencephalogram indicators) (Parshina S. S. et al., 2003; Dikke G. B., 1999; Afanasyeva Т. N., Petrova V. D., 1995; Tsarev А. А., Kudinova М. А., 1997). • Increased overall resistance (immunity) to many different negative factors (Tumanyants Ye. I., Temuryants N. А., 1997). 15 NANOTECHNOLOGY IN MEDICINE Notes 16
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