Folkets hus, Stockholm / 20–23 September 2014 Scandinavian Congress of Rheumatology Programme EFFEKT SÄKERHET www.orencia.se www.orenciapatient.se Den enda biologiska behandlingen vid RA som selektivt modulerar aktiveringen av T-celler Tillgänglig i både subkutan och intravenös beredningsform ORENCIA® (abatacept) 125 mg injektionsvätska för subkutan injektion och 250 mg pulver till koncentrat till infusionsvätska för intravenös infusion. Immunosuppressivt medel. Indikation: Subkutan och intravenös beredningsform: Reumatoid artrit – ORENCIA ® i kombination med metotrexat är indicerad för behandling av måttlig till svår aktiv reumatoid artrit hos vuxna patienter som svarat otillräckligt på tidigare behandling med en eller flera sjukdomsmodifierande antireumatiska läkemedel (DMARDs), inklusive metotrexat (MTX) eller en TNF-hämmare. Vid kombinationsbehandling med abatacept och metotrexat har reduktion av progressiv leddestruktion och förbättring av fysisk funktion påvisats. Endast intravenös beredningsform: Polyartikulär juvenil idiopatisk artrit - ORENCIA® i kombination med metotrexat är indicerad för behandling av måttlig till svår aktiv polyartikulär juvenil idiopatisk artrit (JIA) hos pediatriska patienter från 6 års ålder och uppåt som svarat otillräckligt på andra DMARDs inklusive åtminstone en TNF-hämmare. ORENCIA® har inte studerats hos barn under 6 år. Förpackning: Fyra förfyllda sprutor med 125 mg abatacept i en ml lösning. En injektionsflaska med 250 mg pulver och en silikonfri spruta. Ytterligare information: ORENCIA® är receptbelagt och förmånsberättigat. För fullständig information och pris, se www.fass.se. Baserad på produktresumé: 28 april 2014. www.bms.se ORE.SWE.JUL.2014 Kontraindikationer: Allvarliga okontrollerade infektioner, som sepsis och opportunistiska infektioner. Överkänslighet mot den aktiva substansen eller mot något hjälpämne. Contents 02.Committee 03. Welcome 04. Social programme 05. General Information 07. Congress programme at a Glance 12. Congress Programme 21. Pre-courses 24. Congress venue map 25. Exhibition Plan and Listing 26. Poster presentations Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Committee Local organising committee Katerina Chatzidionysiou Jan Alvar Lindencrona Stina Nordman Ioannis Parodis Anna Tjärnlund Anna Rudin Lars Rönnblom Thomas Skogh Gunnar Sturfelt Ronald van Vollenhoven Solveig Wållberg Jonsson Scientific committee Congress Secretariat Ingrid E. Lundberg Niels Graudal Gerdur Gröndal Björn Gudbjörnsson Stefan Hagelberg Glenn Haugeberg Gunnar Husby Søren Jacobsen Meliha Kapetanovic Dan Nordström Anne Marie Norén Tom Pettersson Saedis Saevarsdottir Kristian Stengaard Pedersen Ulrik Tarp Anna Tjärnlund Carl Turesson Rantalaiho Vappu Caroline Åkerhielm MCI Stockholm Email: [email protected] Phone: +46 8 5465 1500 Local scientific committee Johan Askling Maria Bokarewa Hans Carlssten Lennart Jacobsson Lars Klareskog Ralph Nisell Solbritt Rantapää Dahlqvist 2 Gold Sponsors Bristol-Myers Squibb Celgene Pfizer AB UCB Pharma AB Silver Sponsors MSD AB Roche AB Bronze sponsors AbbVie Eli Lilly GlaxoSmithKline Hospira Nordic AB Janssen-Cilag AB Medac GmbH Novartis Orion Diagnostica Sobi Thermo Scientific www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Welcome Welcome to the 35th Scandinavian Congress of Rheumatology On behalf of the Board of the Scandinavian Society for Rheumatology and the scientific committee of the Scandinavian Congress of Rheumatology, we wish you a warm welcome to the 35th Scandinavian Congress of Rheumatology in Stockholm September 20-23, 2014. I t is a great privilege to host the 35th Scandinavian Congress of Rheumatology which is an important meeting place for clinicians and scientists in rheumatology in Scandinavia to exchange knowledge, experience and ideas and to promote Scandinavian collaborations and networking. It is a meeting where young and established clinicians and scientists in rheumatology meet across the Scandinavian borders and it is an important educational meeting for clinicians. With the 35th Scandinavian Congress of Rheumatology we have a new organization as the congress, for the first time, is organized by the Scandinavian Society for Rheumatology in collaboration with the national host of the congress, the Swedish Society for Rheumatology. The Scientific committee represents all Scandinavian countries and also young rheumatologists. In the 2014 congress we collaborate with patient representatives in Nordic Rheuma Council, with Nordic Health professionals and with paediatric rheumatologists from Scandinavia. The 35th Scandinavian Congress of www.scr2014.se Rheumatology has a focus on areas that are of common interest in the Scandinavian countries and the overall topic for this congress is Prevention and therapy in rheumatic diseases integrating biology, life style and outcome. One of the goals of this congress is to promote young scientists working with rheumatology research and to promote interdisciplinary research in Scandinavia. There is also a focus on education in clinical rheumatology and rheumatology research. The program is based on plenary lectures with update on treatment, scientific sessions with introductory talks and selected oral presentations from submitted abstracts, parallel workshops where interest groups present topics for discussions, and poster presentations with organized poster tours. We want to emphasize discussions on how we can develop Scandinavian collaborations in the future, all to the best for clinical care of patients with rheumatic diseases. To strengthen the educational part of the congress there are two one-day pre-courses; one with a clinical focus and one with a research focus for PhD students 3 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden in rheumatology research. We are very happy to welcome all distinguished speakers that kindly have accepted our invitation to the Congress. This will ensure a high scientific level of the program. We are also very pleased to have received a high number of excellent abstracts of which some have been selected for oral presentations and we will have two large poster sessions. A warm welcome to the 35th Scandinavian Congress of Rheumatology and we wish you all an interesting and interactive meeting! On behalf of the board of the Scandinavian Society for Rheumatology, the Swedish Society for Rheumatology and of the Scientific Committee of the Scandinavian Congress of Rheumatology. Stockholm in September 2014 Ingrid Lundberg President of Scandinavian Society for Rheumatology Ralph Nisell President of Swedish Society for Rheumatology Social programme Welcome reception Sunday 21 September, 18.45-21.00 City Conference Centre – Folkets Hus Congress dinner Monday 22 September, 18.30 ”Winterviken” Alfred Nobel’s sculpture factory from 1891 Vinterviksvägen 60 117 65 Stockholm Transportation Boat leaves from Stadshusbron (next to the City Hall) at 18.30 sharp! Return by bus. 4 www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden General Information Congress venue City Conference Centre (CCC), Folkets Hus, which was opened in 1960, was built for many activities with an exciting architectural design. The Congress Hall lies at the heart of the building and can accommodate 1,400 people. Circling the Congress Hall are another 17 conference rooms of varying sizes, exhibition spaces and restaurants. Folkets Hus is also home to Dansens Hus, the primary dance scene in Stockholm, and the nightclub le bon Palais. City Conference Centre (CCC), Folkets Hus Barnhusgatan 12, 111 23 Stockholm Coffee and lunches Coffee and lunches will be served in the exhibition. Exhibition Opening hours for the exhibition Sunday 21 September 15.00 – 21.00 (approx.) Monday 22 September 08.00 – 17.00 Tuesday 23 September 08.00 – 14.00 Insurance Neither the Congress Organisers nor the Congress Secretariat accepts any liability for personal injuries sustained, or for loss or damage to property belonging to congress participants, either during or as a result of the congress. It is strongly recommended that you purchase an insurance policy of www.scr2014.se your choice as you register for the congress and book your travel. The insurance should be purchased in your country of origin. Language The official congress language is English. There will be no simultaneous translation. Taxi We highly recommended that you use one of the Taxi-company here below. Taxi Stockholm +46 8 15 00 00 Taxi Kurir +46 8 30 00 00 Registration and Information desk opening hours The Registration desks are located outside the Congress Hall A at Stockholm City Conference Center. Opening hours: Sunday 21 September Monday 22 September Tuesday 23 September 11.00–18.30 07.30–18.00 07.30–16.00 Internet Complimentary Wi-Fi is provided for all delegates and exhibitors attending the congress. Network: CCC Password: Stockholm Name badges All participants are requested to wear their name badge during the congress. Access to all events and to lunch and refreshment 5 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden breaks is only possible with your personal badge. Posters During the lunch there will be poster tours where each poster will be presented during 3 minutes. For interest please sign up at the registration desk. Public transport The nearest underground stations are T-centralen (Vasagatan exit) or Hötorget (Olof Palmes gata exit). A walk from central station/T-centralen takes about 10 minutes, or 5 minutes from Hötorget. For more information please visit www.sl.se/en tural life, Stockholm offers a wide selection of world-class museums and attractions. Most of the city’s attractions can be reached on foot, but public transportation is smooth and efficient. Tourist information For tourist information about Stockholm, Sweden, please visit the following website: www.visitstockholm.com Tourist Information Centre once in Stockholm Speakers Ready Room’ Stockholm Visitor Centre Kulturhuset, Sergel Torg 3, 10327 Stockholm Tel: +46 (0) 8 508 28 508 Email: [email protected] The Speaker Ready Room is located in Room 401. Bring your presentation on a memory stick. Upload your presentation at your earliest convenience, but not later than break prior to your session. Opening hours: Monday to Friday 09.00–18.00 Saturday09.00–16.00 Sunday10.00–16.00 Opening hours Sunday11.30–18.00 Monday07.30–18.00 Tuesday07.30–15.30 Stockholm We are delighted to welcome you to Stockholm, the beautiful capital of Sweden! The city is built on 14 islands connected by 57 bridges. The beautiful preserved buildings of the Old Town, the greenery, the fresh air and the proximity to water are distinctive traits of this city. The Royal National City Park – the first National City Park in the world – is a green space that offers a welcome escape from the rush of the capital. With its 750-year history and rich cul- 6 www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme at a Glance Pre-courses Satellite symposium Workshops Registration/Coffee/Lunch/Posters/Exhibition Key note lectures Social programme/Opening Ceremony/End of Congress Session/Symposium General Assembly Saturday 20 September 11.00–13.00 Registration at Karolinska University Hospital (Pre-courses) 13.00–17.00 Nanna Svartz auditorium, Karolinska University Hospital Pre-course, Clinical update Rolf Luft auditorium, Karolinska University Hospital Pre-course, Translational Science in Rheumatology 17.00 Get together with snacks, Faculty club Karolinska University Hospital (Only for pre-course participants) Sunday 21 September 08.30-11.30 Nanna Svartz auditorium, Karolinska University Hospital Pre-course, Clinical update Rolf Luft auditorium, Karolinska University Hospital Pre-course, Translational Science in Rheumatology 11.00–18.30 Registration at Stockholm City Conference Centre – Folkets Hus 13.00–13.45 General assembly for the Scandinavian Society for Rheumatology Room 300 14.00–15.30 Key note lectures Chairs: Ingrid E. Lundberg, Stockholm, Sweden, Søren Jacobsen, Copenhagen, Denmark Room Hall A 15.30–16.00 Coffee break and Exhibition 16.00–17.30 Symposium How to apply current knowledge compering the effectiveness of treatments for rheumatic diseases. Chairs: Lars Klareskog, Stockholm, Sweden, Katerina Chatzidionysiou, Stockholm, Sweden Room Hall A 17.45-18.45 Opening ceremony Room Hall A 18.45-21.00 Welcome reception at City Conference Center – Folkets Hus Room Exhibition area www.scr2014.se 7 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme at a Glance Monday 22 September 07.30–18.00 Registration 08.00–09.00 SELECTIVE MODULATION OF T-CELL CO-STIMULATION: Towards more effective use of targeted therapies Satellite Symposium sponsored by Bristol –Myers Squibb 09.10–10.40 Parallel scientific sessions A1. Treatment strategies for RA – today and tomorrow Chairs: Ronald van Vollenhoven, Stockholm, Sweden, Till Uhlig, Oslo, Norway Room Hall A B1. Pain in rheumatic diseases – Clinical and molecular aspects Chairs: Jon Lampa, Stockholm, Sweden, Berit Hagemoen Linberg, Lillehammer, Norway Room Hall B C1. Autoinflammatory diseases Chairs: Tom Pettersson, Helsinki, Finland, AnnaCarin Horne, Stockholm, Sweden Room Hall C 10.40–11.00 Coffee break and Exhibition 11.00–12.30 Parallel scientific sessions 12.30–14.00 14.00–15.15 8 Room Hall A A2. The pre-clinical and very early phases of rheumatoid arthritis: Disease mechanisms and opportunities for prevention Chairs: Solbritt Rantapää Dahlqvist, Umeå, Sweden, Carl Turesson, Malmö, Sweden Room Hall A B2. Fatigue and cognitive dysfunction in rheumatic diseases Chairs: Ann Knight, Uppsala, Sweden, Lykke M. Ørnbjerg, Glostrup, Denmark Room Hall B C2. Osteoarthritis: Molecular and clinical aspects Chairs: Ralph Nisell, Stockholm, Sweden, Merete Hetland, Copenhagen, Denmark Room Hall C Lunch and poster viewing/Exhibition Parallel workshops Cardiovascular morbidity in rheumatic disease: What’s up? Chairs: Solveig Wållberg Jonsson, Umeå, Sweden, Markku Kauppi, Helsinki, Finland Room Hall B Predictors of disease severity and treatment response in patients with rheumatoid arthritis Chairs: Merete Hetland, Copenhagen, Denmark, Alf Kastbom, Linköping, Sweden Room Hall A Scandinavian clinical registries for the benefit of patients and research: What’s on and What’s new? What can we learn from each other? Chairs: Johan Askling, Stockholm, Sweden Room 307 www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme at a Glance 15.15–15.35 15.35–16.50 17.00–18.00 18.30 www.scr2014.se Salivary gland biopsies in Sjögren’s syndrome- an important diagnostic tool. Chairs: Gunnel Nordmark, Uppsala, Sweden, Roald Omdal, Stavanger, Norway Room Hall C Transition From Child To Adult With A Rheumatic Disease Chair: Bo Magnusson, Stockholm, Sweden Room 300 Coffee break and Exhibition Parallel workshops Cardiovascular prevention in rheumatic everyday practice Chairs: Anna Södergren, Umeå, Sweden, Kim Hörslev-Petersen, Odense, Danmark Room Hall B National Guidelines – How do they compare and what is the intention of the guidelines? Chairs: Tore Kvien, Oslo, Norway, Ronald van Vollenhoven, Stockholm, Sweden Room Hall A Myositis – how we can work together in Scandinavia to Improve patient care. Chairs: Ingrid E. Lundberg, Stockholm Sweden, Øyvind Molberg, Oslo, Norway Room Hall C Rehabilitation for patients with rheumatic diseases in at future perspective Chairs: Carina Thorstensson, Gothenburg, Sweden Room 307 Aspects of axial SpA Satellite Symposium sponsored by Pfizer. Room: Hall A Management of AxSpA–when and how to treat and how to manage immunogenicity Satellite Symposium sponsored by UCB. Room: Hall C Congress Dinner at Vinterviken 9 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme at a Glance Tuesday 23 September 07.30–16.00 Registration 08.00–09.00 Facing the challenge of patient perspectives in psoriatic arthritis Satellite Symposium sponsored by Celgene. 09.10–10.40 Parallel scientific sessions A3. Modern anti-rheumatic treatment and current strategies for prevention of infections Chair: Carl Turesson, Lund, Sweden, Anna Rudin, Gothenburg, Sweden Room Hall A B3. Adolescent rheumatology Chairs: Anne Carlsson, Karlstad, Sweden, Stefan Hagelberg, Stockholm, Sweden Room Hall B C3. Spondyloarthritis (Ankylosing spondylitis and psoriatic arthritis). Chairs: Lennart Jakobsson, Göteborg, Sweden, Björn Guðdbjörnsson, Reykjavik, Iceland Room Hall C 10.40–11.00 Coffee break and Exhibition 11.00–12.30 Parallel scientific sessions A4. Immunological mechanisms and clinical phenotypes inflammatory systematic diseases Chairs: Gunnel Nordmark, Uppsala, Sweden, Christopher Sjöwall, Linköping, Sweden Room Hall A B4. Life-style factors and intervention in rheumatic diseases Chairs: Christina Opava, Stockholm, Sweden, Johan Isaksson, Umeå, Sweden Room Hall B C4. Modern imaging – clinical and molecular Chairs: Glenn Haugeberg, Kristiansand, Norway, Dan Nordström, Helsinki, Finland Room Hall C 12.30–14.00 Lunch and poster viewing/Exhibition 14.00–15.30 Key note lectures Chairs. Frank Wollheim Lund, Sweden, Solbritt Rantapää Dahlqvist, Umeå, Sweden 15.30–16.00 End of congress 10 Room Hall A Room Hall A www.scr2014.se VÄLKOMMEN TILL MONTER G4 UNDER SCR-DAGARNA OCH TILL VÅRT SYMPOSIUM I KONGRESSHALL C DEN 22/9, KL 17–18! Nu me dt indikat re godkända ion reuma er inom RA, ax tologi: SpA oc h PsA! Starta resan med målet i sikte. Om snabb effekt och ett tidigt svar med långsiktigt resultat är målet, kan Cimzia® (certolizumab pegol) vara vägen dit1–6. CIMZIA® (CERTOLIZUMAB PEGOL) Cimzia® 200 mg injektionsvätska, lösning, Rx, F. Farmakologisk grupp: Immunsuppressiva medel, TNF-alfa hämmare. ATC-kod: L04AB05. Indikationer: Reumatoid artrit. Cimzia, i kombination med metotrexat (MTX), är indicerat för behandling av måttlig till svår aktiv reumatoid artrit (RA) hos vuxna patienter när behandling med sjukdomsmodifierande antireumatiska läkemedel (DMARD) inklusive metotrexat är otillräcklig. Cimzia kan ges som monoterapi vid intolerans mot metotrexat eller om fortsatt behandling med metotrexat är olämplig. Cimzia har visats minska progressionshastigheten av ledskador mätt med röntgen och förbättra fysiska funktioner när det ges tillsammans med metotrexat. Axial spondylartrit. Cimzia är indicerat för behandling av vuxna patienter med svår aktiv axial spondylartrit, innefattande: Ankyloserande spondylit (AS). Vuxna med svår aktiv ankyloserande spondylit som haft ett otillräckligt svar på, eller är intoleranta mot behandling med icke-steroida antiinflammatoriska läkemedel (NSAID). Axial spondylartrit utan radiologiska tecken på AS. Vuxna med svår aktiv axial spondylartrit utan radiologiska tecken på AS men med objektiva tecken på inflammation genom förhöjt CRP och/eller MR, som haft ett otillräckligt svar på, eller är intoleranta mot NSAID. Psoriasisartrit. Cimzia, i kombination med metotrexat (MTX), är indicerat för behandling av aktiv psoriasisartrit hos vuxna patienter när behandling med sjukdomsmodifierande antireumatiska läkemedel (DMARD) haft otillräcklig effekt. Cimzia kan ges som monoterapi vid intolerans mot metotrexat eller om fortsatt behandling med metotrexat är olämplig. Beredningsform och förpackning: Injektionsvätska, lösning, 200 mg/ml i förfylld spruta. Varje förpackning innehåller 2 sprutor à 1 ml. Kontraindikationer: Överkänslighet mot den aktiva substansen eller mot något hjälpämne. Aktiv tuberkulos eller andra svåra infektioner såsom sepsis eller opportunistiska infektioner. Måttlig till svår hjärtsvikt (NYHA klass III/IV). Datum för översyn av produktresumé 2014-05-16. För fullständig information, varningsföreskrifter och aktuella priser se www.fass.se. 14-MA-0043 May 2014. Referenser: 1. Cimzia® Produktresumé, 2014-05-16. 2. Keystone E, et al. Ann Rheum Dis 2013;0:1–7. doi:10.1136/annrheumdis-2013-203695. 3. Landewé R, et al. Ann Rheum Dis 2014;73:39–47. 4. Landewé R, et al. Arthritis Rheum 2013;65(10):S767. 5. Mease PJ, et al. Ann Rheum Dis 2014;73:48–55. 6. Mease PJ, et al. Arthritis Rheum 2013;65(Suppl. 10):S132, Abstract 312. Läs mer om alla indikationerna på www.fass.se 14-CZP-0096 aug 2014 UCB Pharma AB, Stureplan 4c, 114 35 Stockholm, tel. 040-29 49 00 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme Sunday 21 September 11.00-18.30 Registration 13.00–13.50 General assembly for the Scandinavian Society for Rheumatology Room: 300 14.00-15.30 Key note lectures Chairs: Ingrid E.Lundberg, Stockholm, Sweden, Søren Jacobsen, Copenhagen, Denmark Room. Hall A 14.00–14.45 How to treat the individual patient with the right drug: Personalized medicine in rheumatic diseases – Fact or Fiction? Mathias Uhlén, Stockholm, Sweden 14.45–15.30 Getting familiar with RA: What does family history tell us? Johan Askling, Stockholm, Sweden 15.30–16.00 Coffee break and Exhibition 16.00–17.30 How to apply current knowledge comparing the effectiveness of treatments for rheumatic diseases. Chairs: Lars Klareskog, Stockholm, Sweden, Katerina Chatzidionysiou, Stockholm, Sweden Room: Hall A Introduction: Lars Klareskog, Stockholm, Sweden Lessons from comparative controlled effectiveness studies of RA and other rheumatic diseases. Ronald van Vollenhoven, Stockholm, Sweden Lessons from register-based studies: Treating arthritis in the real-life individual setting. Merete Hetland, Copenhagen, Denmark Predicting response – are we closer to a personalized therapeutic approach? Tore Kvien, Oslo, Norway Selected abstract: Initial Infliximab is not Cost-Effective Added on to a RemissionTargeted Combination Therapy in Early Rheumatoid Arthritis. The 2-year Results of the Randomized Clinical NEO-RACo Trial, Vappu Rantalaiho, Lappeenranta, Finland 17.45–18.45 Opening ceremony Room: Hall A 18.45–21.00 Welcome reception at City Conference Centre – Folkets Hus Room Exhibition area 12 www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme Monday 22 September 07.30–18.00 Registration 08.00–09.00 SELECTIVE MODULATION OF T-CELL CO-STIMULATION: Towards more effective use of targeted therapies – Satellite Symposium sponsored by Bristol – Myers Squibb 09.10–10.40 Parallel scientific sessions 09.10–10.40 A1. Treatment strategies for RA – today and tomorrow. Chairs: Ronald van Vollenhoven, Stockholm, Sweden, Till Uhlig, Oslo, Norway Room: Hall A Room: Hall A Lessons from Fin-RACO and Neo-RACO Vappu Rantalaiho, Tampere, Finland Lessons from CIMESTRA and OPERA Kim Hörslev-Pedersen, Odense, Denmark Lessons from ARCTIC Espen Haavardsholm, Oslo, Norway Selected abstracts: Impact of Physicians’ Activity and Adherence to Treat-to-Target strategy on Outcomes in early Rheumatoid Arthritis: a subanalysis of the Neo-RACo trail. Laura Kuusalo, Turku, Finland Does disease activity at start of biologic therapy influence productivity losses in patients with RA? Kari Johansson, Karolinska Institutet, Stockholm, Sweden 09.10–10.40 B1. Pain in rheumatic diseases – Clinical and molecular aspects. Chairs: Jon Lampa, Stockholm, Sweden, Berit Hagemoen Linberg, Lillehammer, Norway Room: Hall B Pain mechanisms in arthritis. Camilla Svensson, Stockholm, Sweden Pain mechanisms and coping in pediatric rheumatology. Troels Herlin, Aarhus, Denmark Pain in rheumatic diseases-from a clinical perspective. Tuulikki Sokka-Isler, Jyväskylä, Finland Selected abstracts: The relation between pain and inflammation in early Rheumatoid Arthritis – Long- term follow up in the Swedish population-based EIRA and SRQ register Maria Sandberg, Stockholm, Sweden. Pain in Adult Idiopathic Inflammatory Myopathies Crisitna Gonzalez-Echavarri, Vizaya, Spain. www.scr2014.se 13 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme 09.10–10.40 C1. Autoinflammatory diseases. Chairs: Tom Pettersson, Helsinki, Finland, AnnaCarin Horne, Stockholm, Sweden Room: Hall C Autoinflammatory diseases including crystal induced arthropathies. Alexander So, Lausanne, Switzerland. Genetic explanations to autoinflammatory diseases. Alf Kastbom, Linköping, Sweden. Inflammasome as a target of therapy. Kari Eklund, Helsinki, Finland 10.40–11.00 Coffee break and Exhibition 11.00–12.30 Parallel scientific sessions 11.00–12.30 A2. The pre-clinical and very early phases of rheumatoid arthritis: Disease mechanisms and opportunities for prevention. Chairs: Solbritt Rantapää Dahlqvist, Umeå, Sweden, Carl Turesson, Malmö, Sweden Room: Hall A Biomarkers and disease mechanisms in the pre-clinical phase of RA. Heidi Kokkonen, Umeå, Sweden The role of hormone related factors in the development of RA. Mitra Pikwer, Eskilstuna, Sweden Strategies for very early identification of RA. Anette van der Helm-van Mil, Leiden, The Netherlands Selected abstracts: Characterization of Lung Inflammation and Identification of Shared Citrullinated Targets in the Lungs and Joints of Early Rheumatoid Arthritis. Vijay Balasingh, Stockholm, Sweden When does the female predominance in RA start – does sex influence the risk of ACPA development. Aase Haj-Hensvold, Stockholm, Sweden 11.00–12.30 B2. Fatigue and cognitive dysfunction in rheumatic diseases Chairs: Ann Knight, Uppsala, Sweden, Lykke M. Ørnbjerg, Glostrup, Denmark Room: Hall B Clinical manifestations of fatigue and cognitive dysfunction on SLE. Susanne Petterson, Stockholm/Uppsala, Sweden The impact of trauma and surgery on longterm cognitive function, the role of inflammation. Lars I. Eriksson, Stockholm, Sweden. Molecular mechanisms of fatigue and cognitive dysfunction in neuro-SLE. Margreet Steup-Beekman, Leiden, The Netherlands 14 www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme Selected abstracts: The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in the Quest-RA program. Kathrine Lederballe-Grön, Copenhagen, Denmark. Fatigue fluctuates substantially in patients with stable rheumatoid arthritis treated with biological agents. Ole Rintek Mades, Gentofte, Denmark. 11.00–12.30 C2. Osteoarthritis: Molecular and clinical aspects. Chairs: Ralph Nisell, Stockholm, Sweden, Merete Hetland, Copenhagen, Denmark Room: Hall C Osteoarthritis – genotypes and phenotypes. Helgi Jonsson, Reykjavik, Iceland Spinal osteoarthritis and pain – molecular and clinical aspects. Eva Kosek, Stockholm, Sweden New molecular and therapeutic opportunities in osteoarthritis. Thomas Pap, Münster, Germany 12.30–14.00 Lunch and poster viewing/Exhibition 14.00–15.15 Parallel workshops 14.00–15.15 Cardiovascular morbidity in rheumatic disease: What’s up? Chairs: Solveig Wållberg Jonsson, Umeå, Sweden, Markku Kauppi, Helsinki, Finland Room: Hall B What’s up on vascular pathogenesis? Ivana Hollan, Lillehammar, Norway What’s up on thrombs and bleeding? Aleksandra Antovic, Stockholm, Sweden Selected abstracts: Atherosclerosis in Systemic Lupus Erythematosus (SLE) and Controls, -An Analysis of SLE Subgroups. Elisabet Svenungsson, Stockholm, Sweden Good Response on Tumour Necrosis Factors Inhibitors are Associated with a Decreased Risk of Acute Coronary Syndromes in Patients with Rheumatoid Arthritis. Lotta Ljung, Umeå, Sweden 14.00–15.15 www.scr2014.se Predictors of disease severity and treatment response in patients with rheumatoid arthritis. Chairs: Merete Hetland, Copenhagen, Denmark, Alf Kastbom, Linköping, Sweden Room: Hall A 15 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme Topics of discussion: • The clinical utility of imaging as a prognostic tool. • Analyses of cartilage biomarkers in early RA. •The rationale for taking smoking into account in treatment decisions. Speakers: Mikkel Østergaard, Copenhagen, Denmark, Carl Turesson, Malmö, Sweden, Saedis Saevarsdottir, Stockholm, Sweden 14.00–15.15 Scandinavian clinical registries for the benefit of patients and research: What’s on and What’s new? What can we learn from each other? Chairs: Johan Askling, Stockholm, Sweden 1.Introduction & presentation of the topic, Johan Askling, Stockholm, Sweden 2. The Finnish perspective, Dan Nordström, Helsinki, Finland 3. The Danish perspective, TBA 4. The Norwegian perspective, Tore Kvien, Oslo, Norway 5.The Icelandic perspective, Björn Guðdbjörnsson, Reykjavik, Iceland 6. The Swedish perspective, Sofia Ernestam, Stockholm, Sverige 7.Open discussion: progress and future strategy chaired by Johan Askling, Stockholm, Sweden 8. Summary and conclusion, Johan Askling, Stockholm, Sweden Room: 307 14.00–15.15 Salivary gland biopsies in Sjögren’s syndrome- an important diagnostic tool. Chairs: Gunnel Nordmark, Uppsala, Sweden, Roald Omdal, Stavanger, Norway Room: Hall C Introductory talk: Minor salivary gland biopsies in diagnosis and prognosis of primary Sjögren’s syndrome. Roland Jonsson, Bergen, Norway Topics of discussion •Biosy sampling; procedure, number of glands and minimum required tissue. • Focus score assessment. • Germinal centre assessment and prognostic value. • Repeated biopsies in treatments studies. Discussion partners: Elke Theander, Malmö, Sweden, Eva Baecklund, Uppsala, Sweden 14.00–15.15 Transition from child to adult with a rheumatic disease Chair: Bo Magnusson, Stockholm, Sweden Karolina Larsson, Gothenburg, Sweden 15.15–15.35 Coffee break and Exhibition 15.35–16.50 Cardiovascular prevention in rheumatic everyday practice Chairs: Anna Södergren, Umeå, Sweden, Kim Hörslev-Petersen, Odense, Danmark 16 Room 300 Room: Hall B www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme Cardiovascular screening of patients with rheumatic disease. Examples from Nordic countries. Anna Södergren, Umeå, Sweden, Anne-Grete Semb, Oslo, Norway An electronic aid in the Swedish register. Marika Kvarnström, Stockholm, Sweden 15.35–16.50 National Guidelines – How do they compare and what is the intention of the guidelines? Chairs: Tore Kvien, Oslo, Norway, Ronald van Vollenhoven, Stockholm, Sweden Topics of discussion: • Strengths and weakness in rheumatology guidelines. •Similarities and difference in guidelines from different Nordic countries. • The development of guidelines and major points of controversy. Introductory talk: Challenges in international and national guidelines, Ronald van Vollenhoven, Stockholm, Sweden Discussion partners: Tuulikki Sokka, Finland, Carl Turesson, Sweden, Björn Guðdbjörnsson, Iceland Room: Hall A 15.35–16.50 Myositis - how we can work together in Scandinavia to improve patient care. Chairs: Ingrid E. Lundberg, Stockholm, Sweden, Øyvind Molberg, Oslo, Norway • Development of new classification critera for myositis Anna Tjärnlund, Stockholm, Sweden • How shall we treat myositis patients with ILD? Clinical experience with rituximab treatment in the anti-synthetase syndrome. Helena Andersson, Oslo, Norway • When should muscle biopsies be repeated. Ingrid E. Lundberg, Stockholm, Sweden • Myositis specific autoantibodies - test available for clinical practice. Johan Rönnelid, Uppsala Room: Hall C 15.35–16.50 Rehabilitation for patients with rheumatic diseases in a future perspective. Chairs: Carina Thorstensson, Gothenburg, Sweden Room: 307 To illuminate the challenges and possibilities of future rehabilitation within rheumatology. Introduciton: Christina Opava, Stockholm, Sweden Discussion partners: Inger Tollefsrud, Lillehammer, Norway, Trine Seneca, Århus, Denmark, Åsa Revenäs, Stockholm. Sweden 17.00–18.00 Aspects of axial SpA Satellite Symposium sponsored by Pfizer Room: Hall A 17.00–18.00 Management of AxSpA-when and how to treat and how to manage immunogenicity .Satellite Symposium sponsored by UCB Room: Hall C 18.30 Congress dinner at Winterviken www.scr2014.se 17 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme Tuesday, September 23 07.30-16.00 Registration 08.00–09.00 Facing the challenge of patient perspectives in psoriatic arthritis. Satellite Symposium sponsored by Celgene 09.10–10.40 Parallel scientific sessions 09.10–10.40 A3. Modern anti-rheumatic treatment and current strategies for prevention of infections. Chairs: Carl Turesson, Lund, Sweden, Anna Rudin, Gothenburg, Sweden Room: Hall A Room: Hall A Multiple determinants of risk for infections in rheumatic patients. Adrian Richter, Berlin, Germany Screening for infections in rheumatic diseases. What is meaningful in clinical practice? Søren Jacobsen, Copenhagen, Denmark Common vaccinations and modern anti-rheumatic treatment. What is meaningful in clinical practice? Meliha C Kapetanovic, Lund, Sweden Selected abstract: The association between antibody levels before and after 7-valent pneumococcal conjugate vaccine immunization and subsequent pneumococcal infection in arthritis patients. Johanna Nagel, Lund, Sweden 09.10–10.40 B3. Adolescent rheumatology Chairs: Anne Carlsson, Karlstad, Sweden, Stefan Hagelberg, Stockholm, Sweden Room: Hall B Autoimmune phenotype in adolescence. Debajit Sen, London, UK Long-term development of juvenile arthritis regarding disease progress and socioeconomic factors. Helena Forsblad-d’Elia, Gothenburg, Sweden Healthy adolescence and unhealthy behavior in adolescents with chronic conditions. Kristina Kelly Berg, Gothenburg, Sweden 09.10–10.40 C3. Spondyloarthritis (Ankylosing spondylitis and psoriatic arthritis). Chairs: Lennart Jakobsson, Göteborg, Sweden, Björn Guðdbjörnsson, Reykjavik, Iceland Room: Hall C New aspects of etiology and pathogenesis of psoriasis and psoriatic arthritis. Mona Ståhle, Stockholm, Sweden 18 www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme Modern management of ankylosing spondylitis. Irene van der Horst-Bruinsma, Amsterdam, The Netherlands Diagnosis, treatment and costs of spondyloarthritis today: Epidemiology and health economy motivates more active care for these patients. Emma Haglund, Halmstad/Lund, Sweden Selected abstracts: Long-term 52 Week Results of PALACE 1, aPhase 3, Randomized, Controlled Trial of Apremilast,an Oral Phosphodiesterase Inhibitor, in Patients With Psoriatic Arthritis. Adewale Adebajo, Sheffield, UK Aortic regurgitation is common in ankylosing spondylitis and justifies routine echocardiographic screening. Eva Klingberg, Gothenburg, Sweden 10.40–11.00 Coffee break and Exhibition 11.00–12.30 A4. Immunological mechanisms and clinical phenotypes in inflammatory systematic diseases. Chairs: Gunnel Nordmark, Uppsala, Sweden, Christopher Sjöwall, Linköping, Sweden Room: Hall A Immunopathogenic mechanisms of systematic autoimmune disease. Marie Wahren-Herlenius, Stockholm, Sweden Connecting the autoimmune response to disease manifestations in systematic inflammatory disease. Riita Lahesmaa, Turku, Finland Proteomic and metabolomics in the classification of SLE subsets. Per-Johan Jakobsson, Stockholm, Sweden Selected abstracts: CD28null T cells are myotoxic to autologous muscle cells from patients with polymyositis. Andreas Fasth, Stockholm, Sweden Interferon (IFN)-λ1/3, but not IFN-α, is a marker of poor response to treatment in lupus nephritis. Agneta Zickert, Stockholm, Sweden 11.00–12.30 B4. Life-style factors and intervention in rheumatic diseases. Chairs: Christina Opava, Stockholm, Sweden, Johan Isaksson, Umeå, Sweden Room: Hall B Effects of exercise, smoking, alcohol and diet (BMI) on disease course and response to therapies in RA. Saedis Saevarsdottir, Stockholm, Sweden How to implement exercise programs in osteoarthritis. Methodological and psychological challenges. Carina Thorstensson, Gothenburg, Sweden www.scr2014.se 19 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme Impact of societal and environmental factors on long term outcome in rheumatoid arthritis. Till Uhlig, Oslo, Norway Selected abstracts: To which extent may the familial risk of rheumatoid arthritis be explained by established RA risk factors. Xia Jiang, Stockholm, Sweden Parity and severity of ACPA-positive/-negative rheumatoid arthritis. Results from the Swedish EIRA study. Mitra Pikwer, Lund, Sweden 11.00–12.30 C4. Modern imaging – clinical and molecular. Chairs: Glenn Haugeberg, Kristiansand, Norway, Dan Nordström, Helsinki, Finland Room: Hall C How to use imaging in SPA in clinical practice. Mikkel Østergaard, Copenhagen, Denmark Imaging in vasculitis with focus on PET. Laura Pirilä, Turku, Finland Selected abstacts: The diagnosic utility of hand & wrist fluorescence optical imaging in evaluating active synovitis. Yogan Kisten, Stockholm, Sweden Magnetic Resonance Imaging-Assessment of Early Response to Certolizumab Pegol in Rheumatoid Arthritis. Mikkel Østergaard, Copenhagen, Denmark Diagnostic utility of musculoskeletal ultrasound in patients with suspected arthritis – a probabilistic approach. Hamed Rezaei, Stockholm, Sweden 12.30–14.00 Lunch and poster viewing/Exhibition 14.00–15.30 Keynote Lectures Chairs: Frank Wollheim, Lund, Sweden, Solbritt Rantapää Dahlqvist, Umeå, Sweden Room: Hall A Update on management of SLE Lars Rönnblom, Uppsala, Sweden Update on management of ANCA associated vasculitis David Jayne, Cambridge, UK 15.30–16.00 End of congress Invitation to the Scandinavian Congress of Rheumatology 2016 Farewell mingles 20 www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Congress Programme Saturday 20–21 September – Parallel pre-courses Saturday 20 September Clinical update Nanna Svartz auditorium, Karolinska University Hospital 13.00–13.05 Welcome Meliha C Kapetanovic, Lund, Sweden 13.05–13.50 Ultrasound in rheumatology. Hilde Berner Hammer, Oslo, Norway 13.50–14.35 MRI analysis – to assess efficacy of treatment. Mikkel Østergaard, Copenhagen, Denmark 14.35–14.55 Coffee break 14.55–15.40 Scleroderma clinical update Roger Hesselstrand, Lund, Sweden 15.45–17.00 Practical demonstrations (rotation between 4 stations) 1.Basic ultrasound of joints Hamed Rezaei, Stockholm, Sweden, Erik af Klint, Stockholm, Sweden 2.Nailfold capillaroscopy Roger Hesselstrand, Lund, Sweden, Annica Nordin, Stockholm, Sweden 3.Gout and pseudogout (microscopy) Alexander So, Lausanne, Switzerland, Esbjörn Larsson, Stockholm, Sweden 4.Muscle strength test and muscle biopsy (video) Maryam Dastmalchi, Stockholm, Sweden 17.00 Informal discussions with snacks (Only for pre-course participants) Sunday 21 September 8.30–9.15 Update on Sjögrens syndrome Elke Theander, Malmö, Sweden 9.15–10.00 Management of crystal arthropathies Alexander So, Lausanne, Switzerland 10.00–10.20 Coffee break 10.20–10.55 Inflammatory myopathies- update on management. Ingrid E. Lundberg, Stockholm, Sweden 10.55–11.30 Cardiovascular risk factors in SLE- Clinical implications. Elisabet Svenungsson, Stockholm, Sweden Lunchbox www.scr2014.se 21 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Saturday 20 September Translational Science in Rheumatology Rolf Luft auditorium, Karolinska University Hospital 13.00–13.10 Welcome and introduction. Anna Tjärnlund, Stockholm, Sweden 13.10–14.00 T cells and adaptive immunity (and targets for therapy) in rheumatic diseases. Vivianne Malmström, Stockholm, Sweden 14.00–15.00 B cells in autoimmunity. Marie Wahren-Herlenius, Stockholm, Sweden 15.00–15.20 Coffee break 15.20–16.10 Innate immunity (and targets for therapy) in rheumatic diseases. Helena Erlandsson-Harris, Stockholm, Sweden 16.10–17.00 Genetics and genetic risk factors in rheumatic diseases. Leonid Padyukov, Karolinska Institutet, Stockholm, Sweden 17.00 Informal discussions with snacks (Only for pre-course participants) 08.30–09.20 Epidemiology in rheumatology research. Lars Alfredsson, Stockholm, Sweden 09.20–10.10 Translational research in rheumatology – effects of exercise. Ingrid E. Lundberg, Stockholm, Sweden 10.10–10.30 Coffee break 10.55–11.30 Type I IFN in rheumatic diseases. Lars Rönnblom, Uppsala, Sweden Sunday 21 September Lunchbox 22 www.scr2014.se PDE4 Please join us at our satellite symposium FACING THE CHALLENGE OF PATIENT PERSPECTIVES IN PSORIATIC ARTHRITIS AMP Tuesday, September 23, 8.00–9.00am, Hall A Chair and Introduction: Prof. Tore Kvien University of Oslo, Norway Speakers: Prof. Mikkel Ostergaard University of Copenhagen, Denmark Dr Chris Edwards University of Southampton, UK To discover more about the role of PDE4 in psoriasis and psoriatic arthritis, visit us on booth G3 or visit discoverPDE4.com cAMP PDE4, phosphodiesterase-4; AMP, adenosine monophosphate; cAMP, cyclic AMP. References: Houslay MD, et al. Keynote review: phosphodiesterase-4 as a therapeutic target. Drug Discov Today. 2005;10(22):1503–1519. Press NJ and Banner KH. PDE4 inhibitors – a review of the current field. In: Lawton G, Witty DR, eds. Progress in Medicinal Chemistry. Amsterdam, The Netherlands: Elsevier; 2009:37–74. Lowes MA, et al. Pathogenesis and therapy of psoriasis. Nature. 2007;445(7130):866–873. Veale DJ, et al. Immunopathology of psoriasis and psoriatic arthritis. Ann Rheum Dis. 2005;64(suppl 2):ii26–ii29. © 2014 Celgene Corporation Date of Preparation August 2014 NS-CELG140040 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden City Conference Centre – Folkets Hus Congress venue map The Congress hall with 2nd and 4th floor 0m 5m 10m 203 204 201 202 28 m 2 50 m 2 28 m 2 Exhibition Hall 26 m 2 34 9 m2 33 m 2 28 m 2 m2 14 m 2 18 m 2 EXHIBITION AREA B2 EXHIBITION AREA A1 18 m 2 Poster Area EXHIBITION AREA C4 EXHIBITION AREA C3 20 m 2 19 m 2 EXHIBITION AREA B11 5 6 m2 EX C6 EA 2 17 m C AR B4 N B3 IO 2 IT HISS/ELEVATOR HOTEL EXHIBITION AREA A9 HIB IT IO N 17 A HIB EXHIBITION AREA B10 AR EA m2 A7 C A Poster Area Poster Area Poster Area 6 m2 EX B 20 m 2 EXHIBITION AREA A8 EXHIBITION AREA C5 EXHIBITION AREA C12 REG. DESK 19 m 2 Congress Hall A REG. DESK Congress Hall B Congress Hall C A1 C6 BACKSTAGE Speaker Ready Room 403 Utställningsytor Exhibition areas FOLKETS HUS Kongresshallen med Våning 2 och 4 The Congress Hall with Second and Forth Floor 402 401 0m 5m 10m Ej uthyrningsbar yta Not available area Utställningsytor/Exhibition areas The congress hall with 3rd and 5th floor 0m 5m 10m 300 307 GARDEROB GARDEROB WARDEROBE WARDROBE Session Room 307 Session Room 300 HISS/ELEVATOR HOTEL B B5 B4 A3 C6 C A C7 C8 C9 A2 A1 C6 C 10 K K/F DM F M 505 504 FOLKETS HUS Kongresshallsläktaren med Våning 3 och 5 The Congress Hall Gallery with Third and Fifth Floor 503 501 502 Utställningsytor Exhibition areas 0m 5m 10m Ej uthyrningsbar yta Not available area Biomöblering/Theatre style 24 www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Exhibition Plan and Listing 0m 5m 10m City Conference Centre G3 B9 G: 6x2.5 meter S: 3x2.5 meter B: 2.5x2 meter CATERING AREA Folkets Hus, Stockholm S1 G4 B10 S3 B8 B7 B6 B5 G1 G2 B11 B4 B3 B2 CATERING A AREA B1 CATERING AREA CATERING AREA 2014-06-19 version 3.2 POSTERS AREA Company CATERING AREA Booth no AbbVie B8 Bristol-Myers Squibb G1 Celgene Eli Lilly Company CATERING AREA MSD AB Novartis POSTERS AREA A CA G3 G ARE Orion Diagnostica TERING AREA RIN CATE B6 Pfizer AB B11 Booth no S1 B10 B5 G2 Roche AB S3POSTERS AREA Hospira Nordic AB B2 Sobi B1 Janssen-Cilag AB B7 Thermo Scientific Medac GmbH B9 UCB Pharma AB GlaxoSmithKline POSTERS AREA Your Event Supplier www.scr2014.se B3 & B4 G4 REGISTRATION AREA 25 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Poster presentations POSTER SESSION MONDAY. PP106 In early RA, the Multi-Biomarker During the lunch there will be poster tours where each poster will be presented during 3 minutes. Disease Activity score at different timepoints is predictive of subsequent radiographic progression. Karen Hambardzumyan, Rebecca Bolce, Saedis Saevarsdottir, Kristina Forslind, Ingemar Petersson, Pierre Geborek, Sofia Ernestam, Eric Sasso, David Chernoff, Scott Cruickshank, Ronald van Vollenhoven Pre-clinical and early phases of rheumatoid arthritis PP101 The association between postmenopausal hormone therapy and the risk of rheumatoid arthritis: results from the Swedish EIRA study. Cecilia Orellana, Saedis Saevarsdottir, Lars Klareskog, Lars Alfredsson, Camilla Bengtsson PP102 What is the Predictive Value of a Family History of Arthritis-Related Conditions on the Risk of Rheumatoid Arthritis, and Does It Differ between Seropositive and Seronegative Disease? Thomas Frisell, Karin Hellgren, Johan Askling PP103 Subclinical synovitis of the hands and wrists detected by fluorescence optical imaging and ultrasound. Yogan Kisten, Noemi Györi, Hamed Rezaei, Anna Karlsson, Erik af Klint, Ronald van Vollenhoven PP105 Dietary impact on treatment results of MTX in patients with RA. Cecilia Lourdudoss, Alicja Wolk, Camilla Bengtsson, Lars Alfredsson, Ronald van Vollenhoven 26 PP107 Using the Multi-Biomarker Disease Activity score as a complementary inclusion criterion for clinical trials in rheumatoid arthritis may enhance recruitment. Karen Hambardzumyan, Rebecca Bolce, Saedis Saevarsdottir, Kristina Forslind, Sofia Ernestam, Ingemar Petersson, Eric Sasso, C. C. Hwang, Oscar Segurado, Pierre Geborek, Ronald van Vollenhoven PP108 Anti citrullinated protein antibodies (ACPA) facilitate migration of synovial tissue-derived fibroblasts. Meng Sun, Vijay Joshua, Aase Haj Hensvold, Marianne Engström, Ileana R. Botusan, Sergiu B. Catrina, Vivianne Malmström, Anca I. Catrina, Heidi Wähämaa PP109 Presene of Anti-Carbamylated Protein Antibodies Prior to Onset of Symptoms of Rheumatoid Arthritis and is Associated with Radiological Progression in Early Rheumatoid Arthritis. Mikael Brink, Marije K. Verheul, Johan Rönnelid, Rikard Holmdahl, Rene E.M. Toes, Lars Klareskog, Leendert A. Trouw, Solbritt Rantapää Dahlqvist www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden OP04/PP110 Characterization of Lung Inflammation and Identification of Shared Citrullinated Targets in the Lungs and Joints of Early Rheumatoid Arthritis. Vijay Joshua, Gudrun Reynisdottir, Jimmy Ytterberg, Marianne Engström, Anders Eklund, Magnus Skold, Per-Johan Jakobsson, Johan Rönnelid, Vivianne Malmström, Lars Klareskog, Johan Grunewald, Anca I Catrina PP111 Patterns of Isotype Distribution in Circulating Antibodies in the Pre-clinical Phase of Rheumatoid Arthritis and Their Relation to Smoking. Carl Turesson, Ulf Bergström, Lennart Truedsson, Azita Sohrabian, Lennart Jacobsson, Johan Rönnelid OP05/PP112 When does the female predominance in RA start - does sex influence the risk of ACPA development? Aase Haj Hensvold, Thomas Frisell, Patrik K.E. Magnusson, Johan Askling, Anca Irinel Catrina PP113 Autoantibodies To Citrullinated Proteins Associate With Bone Destruction Marker and Are Modulated By First Anti Rheumatic Treatment In Early Rheumatoid Arthritis. Aase Haj Hensvold, Vijay Joshua, Wangling Li, Michaela Larkin, Ferhan Quresh, Lena Israelsson, Nadine Defranoux, Saedis Saevarsdottir, Anca Irinel Catrina PP114 High Serum Cholesterol Predicts Rheumatoid Arthritis in Women. Carl Turesson, Ulf Bergström, Mitra Pikwer, Jan-Åke Nilsson, Lennart Jacobsson www.scr2014.se PP115 High prevalence of metabolic syndrome in early rheumatoid arthritis patients with normal weight: a case control study. Raili Müller, Mart Kull, Triin Eglit, Annika Aart, Kaja Põlluste, Margus Lember, Riina Kallikorm PP116 Recent infections and risk of rheumatoid arthritis –results from the population-based EIRA case-control study. Maria Sandberg, Camilla Bengtsson, Lars Klareskog, Lars Alfredsson, Saedis Saevars dottir PP117 Self-reprted Physical Activity and the Risk of Rheumatoid Arthritis – a Prospective Study. Sofia Hagel, Elisabet Lindqvist, Ulf Bergström, Mitra Pikwer, Jan-Åke Nilsson, Lennart TH Jacobsson, Carl Turesson Treatment strategies for RA PP119 Adalimumab (Humira®) normalizes melanocortin receptor subtype 2, 3 and 4 expression in CD8+, CD14+ and CD19+ leukocyte subsets in rheumatoid arthritis. Marlene Andersen, Michael Kruse Olesen, Ivan Nagaev, Olga Nagaeva, Jarl Wikberg, Lucia Mincheva-Nilsson, Grethe Neumann Andersen and The Scandinavian Melanocortin Study Group PP120 Methotrexate Therapy Without Initial Dose Escalation. Valgerdur Sigurdardottir, Tomas Husmark, Jörgen Lysholm, Anna Svärd 27 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden PP121 Impact of tumour necrosis factor inhibitor treatment on hand bone loss in rheumatoid arthritis patients treated in clinical practice. Results from the nationwide Danish DANBIO registry. Lykke Midtbøll M. Ørnbjerg, Mikkel Østergaard, Pernille Bøyesen, Trine Jensen, Anja Thormann, Ulrik Tarp, Wolfgang Bøhme, Ditte Dencker, Hanne Lindegaard, Uta Engling Poulsen, Anette Hansen, VIbeke Ringsdal, Anette Schlemmer, Niels Graudal, Anne Rødgaard Andersen, Jakob Espesen, Gina Kollerup, Torben Christensen, Randi Pelck, Bente Glintborg, Ole Madsen, Dorte Vendelbo Jensen, Ole Majgaard, Merete Hetland PP122 The Tissue-Selective Estrogen Complex Efficiently Inhibits Experimental Arthritis and Inflammation-Induced Bone Loss With Minimal Uterine Side Effects. Annica Andersson, Angelina Bernardi, Alexandra Stubelius, Merja NurkkalaKarlsson, Louise Grahnemo, Hans Carlsten, Ulrika Islander PP123 Methotrexate in Rheumatoid Arthritis and Psoriasis/Psoriatic Arthritis: a Comparative Study of Hepatotoxicity. Johanna Karlsson Sundbaum, Vendela Berglund, Johan Back, Niklas Lehto, Irene Vikman, Ola Rollman, Eva Baecklund PP124 The reliability of Disease Activity Score in 28 joints - DAS28 might be overestimated. Rikke Asmussen Andreasen, Mark Nam van Bui Hansen, Inger Marie Jensen Hansen OP02/PP125 Impact of Physicians’ Activity and Adherence to Treat-to-Target 28 strategy on Outcomes in early Rheumatoid Arthritis: a subanalysis of the Neo-RACo trial. Laura Kuusalo, Vappu Rantalaiho, Hannu Kautiainen, Markku Korpela, Kari Puolakka, Marjatta Leirisalo-Repo PP126 In Rheumatoid Arthritis Patients with Stable Low Disease Activity on Etanercept plus Methotrexate, Continuation of Etanercept is Clinically and Radiographically Superior to Discontinuation: Results from a Randomized, Double-Blind Clinical Trial. Mikkel Østergaard, Karin Franck-Larsson, Marjatta Leirisalo-Repo, Till Uhlig, Marita Jansson, Esbjörn Larsson, Fiona Brock, Ronald van Vollenhoven PP127 NORD-STAR: A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheumatoid arthritis. Maria Seddighzadeh and for the NORDSTAR investigators PP128 Variations In The Interval Between Dispensed Doses Were Observed Between Self-Administered Tnf-Inhibitors. Anders Berglund, Esbjörn Larsson PP129 TNF inhibitor therapy and risk of breast cancer recurrence in patients with rheumatoid arthritis. Pauline Raaschou, Thomas Frisell, Johan Askling and The ARTIS Study group OP03/PP130 Does disease activity at start of biologic therapy influence productivity losses in patients with RA? Kari Johansson, Tor Olofsson, Jonas Eriksson, Ronald van Vollenhoven, Heather www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Miller , Ingmar Peterson, Johan Askling, Martin Neovius Pain in rheumatic diseases – clinical and molecular aspects PP131 The relationship between sleep quality and pain, mood status and clinical symptoms in the patients with Fibromyalgia Syndrome: Preliminary results of crosssectional study. Ayhan Bilgici, Gamze Alayli, Yasemin Ulus, Neslihan Hezer, Omer Kuru OP06/PP132 The relation between pain and inflammation in early Rheumatoid Arthritis – Long-term follow up in the Swedish population-based EIRA and SRQ register. Maria Sandberg, Saedis Saevarsdottir, Reem Altawil, Lars Alfredsson, Lars Klareskog, Jon Lampa PP133 Decreased risk for severe persisting pain in elderly patients with early Rheumatoid Arthritis – Results from the Swedish population-based EIRA and SRQ register. Maria Sandberg, Reem Altawil, Lars Alfredsson, Lars Klareskog, Saedis Saevarsdottir, Jon Lampa PP134 Effect of a Thin Dynamic Insole on clinical and ultrasound findings in a pilot study. Sara Lind, Patric Nordström, Yogan Kisten, Adrian Levitsky, Nancy Vivar, Ronald van Vollenhoven OP07/PP136 Pain in Adult Idiopathic Inflammatory Myopathies. Cristina Gonzalez-Echavarri, Ingrid Lundberg, Helene Alexanderson PP137 Remaining pain despite inflammation control in rheumatoid arthritis – longterm increased risk for widespread pain and fatigue. Maria E. Sandberg, Saedis Saevarsdottir, Reem Altawil, Lars Klareskog, Lars Alfredsson, Jon Lampa and The EIRA working group Osteoarthritis- molecular and clinical aspects PP138 Heparin-binding Protein (HBP) in Joint Fluid Distinguishes Rheumatoid Arthritis from Osteoarthritis. Adam Linder, Anders Gülfe, Johanna Nagel PP139 Bone mineral density in postmenopausal women with hip osteoarthritis. Nataliia Grygorieva, Vladyslav Povoroznyuk, Svytoslava Krochak Pain and Walking Ability in Rheumatoid Arthritis. Berit Hagemoen Linberg, Anne Marit Mengshoel Fatigue and cognitive dysfunction in rheumatic diseases PP135 Kaltenborn’s manual mobilization PP140 The Prevalence of Pernicious Anae- method for pain relief in RA hand joints: mia, Cobalamine and Folic Acid Deficiency www.scr2014.se 29 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden among Patients newly diagnosed with Rheumatoid Arthritis. A Descriptive Cross Sectional Study. Niels Lomborg, Søren Andreas Just , Rannveig Gildberg-Mortensen , Rikke Asmussen Andreasen, Inger Marie Jensen Hansen OP09/PP141 Fatigue fluctuates substantially in patients with stable rheumatoid arthritis treated with biological agents. Emilie Lund Esmose, René Cordtz, Ole Rintek Madsen PP142 Fatigue correlates with Mental Health and Quality of Life in Primary Sjögren’s Syndrome. Rezvan Kiani, Lilian Vasaitis, Anncarin Svanberg, Gunnel Nordmark OP08/PP143 The association of fatigue, comorbidity burden, disease activity, disability and gross domestic product in patients with rheumatoid arthritis. Results from 34 countries participating in the Quest-RA program. Kathrine Lederballe Grøn, Lykke Ørnbjerg, Merete Hetland, Tuulikki Sokka and QuestRA investigators PP144 Fatigue in adult idiopathic inflammatory myopathies. Åsa Björklund, Ingrid Lundberg, Helene Alexanderson Comorbidities and rheumatic diseases PP146 Does Rheumatoid arthritis protect against multiple sclerosis, and if so, when? A population-based study. 30 Elizabeth Arkema, Thomas Frisell, Tomas Olsson, Johan Askling PP147 Dietary nutrients and carotid atherosclerosis in SLE patients. Cecilia Lourdudoss, Ronald van Vollenhoven, Johan Frostegård PP148 Heart involvement in systemic sclerosis patients and mice models. Paulius Venalis, Gábor Kumánovics, Hendrik Schulze-Koops, Alfiya Distler, Clara Dees, Pawel Zerr, Katrin PalumboZerr, László Czirják, Zygmunt Mackevic, Ingrid E. Lundberg, Oliver Distler, Georg Schett, Jörg H.W. Distler OP12/PP149 The association between antibody levels before and after 7-valent pneumococcal conjugate vaccine immunization and subsequent pneumococcal infection in arthritis patients. Johanna Nagel, Tore Saxne, Pierre Geborek, Göran Jönsson, Martin Englund, Ingemar F. Petersson, Jan-Åke Nilsson, Lennart Truedsson, Meliha C. Kapetanovic PP150 Expression of HMGB1 and Its Receptors in Hearts of Patients with Coronary Artery Disease with or without Inflammatory Rheumatic Disease: A Biopsy Study. Mei Zong, Ivana Hollan, Huiyuan Xiao, Cecilia Wick, Helena Harris, Ingrid Lundberg OP10/PP151 Atherosclerosis in Systemic Lupus Erythematosus (SLE) and Controls, -An Analysis of SLE Subgroups. Johanna Gustafsson, Kerstin JensenUrstad, Marie Herlitz-Lindberg, Sonia Möller, Susanne Pettersson, Iva Gunnars- www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden son, Anders Larsson, Elisabet Svenungsson PP152 A comparison between patients with rheumatoid arthritis in the western part of Sweden with or without treatment with biologics. Karin Bengtsson, Mats Dehlin, Elisabeth Hilme, Göran Kvist, Barbro Rydberg, Tomas Torstenson, Anna Lindhé, Susanna M Wallerstedt, Helena Forsblad-dÉlia PP153 Frequency of Metabolic syndrome in Patients with Gout: A retrospective cross-sectional study. Melanie Morillon, Inger Marie Jensen Hansen PP154 Increased incidence of low-energy fractures in RA patients from northern Sweden. Solbritt Rantapää Dahlqvist, Kristina Wiberg, Ulrika Bergström, Marie-Louise Öhman PP155 The value of Quantiferon TB Gold In-Tube test in identification of latent tuberculosis in rheumatic patients before treatment with TNF-a blockers in Vilnius University Hospital Santariskiu Clinics. Inesa Arstikyte, Irena Butrimiene, Rolandas Zablockis, Algirdas Venalis OP11/PP156 Good Response on Tumour Necrosis Factor Inhibitors are Associated with a Decreased Risk of Acute Coronary Syndromes in Patients with Rheumatoid Arthritis. Lotta Ljung, Lennart Jacobsson, Solbritt Rantapää Dahlqvist, Johan Askling and ARTIS Study Group www.scr2014.se PP157 Prevalence of comorbidities in rheumatoid arthritis. Does gross domestic product matter? Results from 34 countries in the quest-ra program. Kathrine Lederballe Grøn, Lykke Ørnbjerg, Merete Hetland, Tuulikki Sokka and QUEST-RA investigators Autoinflammatory diseases – clinical and molecular aspects PP158 Gout – an old disease in a new phenotype. Michael Fiene, Beate Fiene, Verena Karnebeck Vasculitis PP159 Inflammation, Vitamin D and Bone Mineral Density in patients presenting with Giant Cell Vasculitis and/or Polymyalgia Rheumatica. Søren A. Just, Rikke Asmussen Andreasen, Rannveig Gildberg-Mortensen, Niels Lomborg, Petur Weihe, Inger Marie Jensen Hansen PP160 Carcinoma of the prostate, RS3PE and Polymyalgia Rheumatica. A case study. Rannveig A. Gildberg-Mortensen, Lars Kjær Nielsen, Erik Øster-Jørgensen, Søren Hess, Inger Marie Jensen Hansen PP161 Clinical and laboratory characteristics associated with visual complications in patients with biopsy-proven giant cell arteritis. Muna Saleh, Carl Turesson, Martin Englund, Peter A Merkel, Aladdin J Mohammad 31 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden PP162 Low CD4/CD8 Ratio is Associated with Lower Immunoglobulin Levels in Granulomatosis with Polyangiitis Patients Receiving Rituximab. Emilio Besada, Johannes C Nossent PP163 Chronic Nasal Carriage of Staphylococcus Aureus in Granulomatosis with Polyangiitis Patients Receiving Rituximab Maintenance: Friend or Foe? Emilio Besada, Wenche Koldingsnes, Johannes C Nossent PP164 Late onset neutropenia in ANCA-associated vasculitis after rituximab treatment Ann Knight, Annette Bruchfeld, Iva Gunnarsson PP165 The use of positron emission tomography (PET) imaging as diagnostic procedure when vasculitis is suspected. Soile Salomäki, Kirsi Taimen, Johanna Silvola, Jukka Kemppainen, Ulla Hohenthal, Antti Saraste, Anne Roivainen, Laura Pirilä PP166 The Impact of Clinical Features and Corticosteroids on Biopsy Findings in Giant Cell Arteritis. Karin Jakobsson, Lennart Jacobsson, Aladdin Mohammad, Jan-Åke Nilsson, Kenneth Warrington, Eric Matteson, Carl Turesson PP167 The diagnostic performance of FDG PET-CT in patients with polymyalgia rheumatica and giant cell arteritis. Rannveig A. Gildberg-Mortensen, Erik Øster-Jørgensen, Søren Hess, Inger Marie Jensen Hansen 32 Molecular aspects on pathogenesis in arthritis/bone destruction PP168 Cathepsin s and cathepsin l in serum and synovial fluid in rheumatoid arthritis with and without autoantibodies. Tomas Weitoft, Anders Larsson, Vivek Manivel, Jörgen Lysholm, Ann Knight, Johan Rönnelid PP169 Chemokine-Mediated Regulation of Th17-Cell Migration as a Novel Mechanism for Estrogen-Induced Amelioration of Experimental Arthritis. Annica Andersson, Alexandra Stubelius, Merja Nurkkala-Karlsson, Cecilia Engdahl, Malin Erlandsson, Louise Grahnemo, Marie K Lagerquist, Ulrika Islander PP170 CD25+CD39+ Tregs are enriched at the site of inflammation of patients with rheumatoid arthritis and impaired in suppressing IL-17A secretion. Jessica Herrath, Karine Chemin, Inka Albrecht, Anca I. Catrina, Vivianne Malmstrom PP171 Alternatively Spliced Isoform Expression of PTPN2 in Rheumatoid Arthritis. Miranda Houtman, Klementy Shchetynsky, Leonid Padyukov PP172 Lasofoxifene and Bazedoxifene Suppress Bone Marrow B cell Development Differently than 17β-estradiol and Do Not Increase Peripheral B cell Activity. Angelina Bernardi, Annica Andersson, Louise Grahnemo, Merja Nurkkala Karlsson, Hans Carlsten, Ulrika Islander www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden PP173 B-cell responses to de novo identified citrullinated fibrinogen peptides are associated with PTPN22 risk allele. Vijay Joshua, Loes Schobers, Lena Israelsson, Monika Hansson, Johan Rönnelid, Anca I Catrina, Ger JM Pruijn, Vivianne Malmström PP174 Osteoclastogenesis Is Enhanced By Anti-Citrullinated Proteins Antibodies In Rheumatoid Arthritis. Akilan Krishnamurthy, Vijay Joshua, Heidi Wähämaa, Nataliya Tarasova, Catia Cerqueira, Elena Ossipova, Nancy Vivar, Khaled Amara, Karin Lundberg, Vivianne Malmström, Per-Johan Jakobsson, Georg Schett, Jimmy Ytterberg, Anca Catrina PP175 HIF-2 α dependent RANKL induction and osteoclastogenesis is augmented by inflammatory cytokines. Shankar Revu, Akilan Krishnamurthy, Xiaowei Zheng, Vivekananda Gupta Sunkari, Ileana Ruxandra Botusan, Marina Korotkova, Sergiu-Bogdan Catrina, Anca Catrina PP176 Identification of a new citrullinated collagen-type II T cell epitope in HLADRB1*1001 positive-reumatoid arthritis patients. Karine Chemin, Eddie James, Jessica Herrath, Inka Albrecht, Catrina Anca, Leonid Padyukov, Lars Rönnblom, Lars Klareskog, Vivianne Malmström PP177 Anti TNF therapy with adalimumab restores the bone metabolism balance through a dual mechanism in rheumatoid arthritis. Akilan Krishnamurthy, Shankar Revu, Aase Hensvold, Petra Neregård, Marianne www.scr2014.se Engström, Erik af Klint, Dimitrios Makrygiannakis, Anca Catrina PP178 Differences in the Auto-reactive Tcell Pool when Restricted by the Highly Related Rheumatoid Arthritis Associated HLADRB1 Alleles *04:01, *04:04 and *01:01. Charlotta Sandin, Christina Gerstner, Hannes Uchtenhagen, Eddie James, Jennifer Pieper, Mary Rieck, Adnane Achour, Jane H Buckner, Tatiana Sandalova, Vivianne Malmström PP179 Endogenous b cell-targeted antigen expression induces tolerance to collagen type ii arthritis in Mice. Sofia Andersson, Tove Eneljung, Sara Tengvall, Lill Mårtensson, Kenth Gustafsson, Holmdahl Rikard, Jan Kihlberg, Anna Stern, Pernilla Jirholt, Inger Gjertsson POSTER SESSION TUESDAY During the lunch there will be poster tours where each poster will be presented during 3 minutes. Comparative effectiveness of treatments for rheumatic diseases PP201 Baricitinib, an Oral Janus Kinase Inhibitor, in the Treatment of Rheumatoid Arthritis: Safety and Efficacy in an OpenLabel, Long-Term Extension Study1. Peter Taylor, Mark Genovese, Ed Keystone, Douglas Schlichting, Scott Beattie, William Macias, Jonas Lundmark (presenter only) 33 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden PP202 In early RA patients with non- PP207 How good is the coverage and how response to methotrexate monotherapy the change in Multibiomarker Disease Activity score is differentially associated with subsequent response to non-biological versus biological therapy. Karen Hambardzumyan, Rebecca Bolce, Saedis Saevarsdottir, Kristina Forslind, Ingemar Petersson, Pierre Geborek, Sofia Ernestam, Eric Sasso, David Chernoff, Scott Cruickshank, Ronald van Vollenhoven accurate are data in the Swedish biologics register (Artis). Hjalmar Wadstrom, Johan Askling, Martin Neovius, Jonas Eriksson to Support Health Economics Research in Rheumatic Diseases. Heather Miller PP208 Drug survival in patients receiving golimumab treatment 2010-2013. Results from the swedish rheumatology quality register. Saedis Saevarsdottir, Michele Santacatterina, Leszek Stawiarz, Carl Turesson, Helena Forsblad-d’Elia, Lennart Jacobsson, Staffan Lindblad and Swedish Rheumatology Quality Register PP204 Costs in relation to disability, OP01/PP209 Initial Infliximab is not disease activity and health-related quality of life in rheumatoid arthritis. Johan A. Karlsson, Jonas Eriksson, Jan-Åke Nilsson, Tor Olofsson, Lars-Erik Kristensen, Martin Neovius, Pierre Geborek Cost-Effective Added on to a RemissionTargeted Combination Therapy in Early Rheumatoid Arthritis. The 2-year Results of the Randomized Clinical NEO-RACo Trial. Vappu Rantalaiho, Janne Martikainen, Hannu Kautiainen, Kari Puolakka, Marjatta Leirisalo-Repo and the NEO-RACo Study Group PP203 Utilization of Nordic Registries PP205 Patient Characteristics in the Prospective International Register of Biologics in SLE (IRBIS-II): year one data. Melinda Mild, Daniel J Wallace, Ann E Clarke, Sasha R Bernatsky, Christine Peschken, Soren Jacobsen, Guillermo RuizIrastorza, John G Hanly, Diane Kamen, Rosalind Ramsey-Goldman, Michelle A Petri, Paul Fortin, Ronald van Vollenhoven and the SLICC group PP206 Sick leave and disability pension in relation to first initiation of biologic therapy across indications: a nationwide cohort study. Jonas Eriksson, Lennart Jacobsson, Lars-Erik Kristensen, Johan Askling, Martin Neovius 34 Spondyloarthritis – pathogenesis and management PP210 Effect of Secukinumab on psoriasis symptoms and physical functioning compared with placebo and etanercept in subjects with moderate-to-severe plaque psoriasis and concomitant psoriatic arthritis: a subanalysis from the phase 3 FIXTURE study. B Sigurgeirsson, AB Gottlieb, RG Langley, S Philipp, RLM Martin, C Papavassilis, S Mpofu www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden PP211 A Number of Autoimmunity-related Gene Polymorphisms are not Associated with Ankylosing Spondylitis in Latvian Population. Julija Zepa, Laila Zepa, Inita Bulina, Anna Sarbantovica, Vladimirs Lavrentjevs, Evita Sikora, Janis Arajs, Aivars Lejnieks, Daina Andersone, Janis Klovins, Liene Nikitina-Zake PP212 A rare case of Potts Disease in Denmark. Azra Osmanagic, Jacob Christian Bang, Rasa Ramoskiene, Inger Marie Jensen Hansen PP213 Comparison of Sociodemographic characteristics, Clinical Variables and Depression in Patients with Psoriasis and Psoriatic Arthritis. Omer Kuru, Sertac Ketenci, Ayhan Bilgici, Gamze Alayli, Yesim Akyol, Yasemin Ulus OP17/PP214 Long-term 52-Week Results of PALACE 1, a Phase 3, Randomized, Controlled Trial of Apremilast, an Oral Phosphodiesterase Inhibitor, in Patients With Psoriatic Arthritis. Adewale Adebajo, Juan Gomez-Reino, Philip Mease, Jürgen Wollenhaupt, ChiaChi Hu, Kamal Shah, Randall Stevens, Arthur Kavanaugh PP215 Long-term 52-Week Results of PALACE 3, a Phase 3, Randomized, Controlled Trial of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, in Patients With Psoriatic Arthritis and Current Skin Involvement. Christopher Edwards, Francisco Blanco, Jeffrey Crowley, ChiaChi Hu, Randall Stevens, Charles Birbara www.scr2014.se PP216 Long-term Safet and Tolerability of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, in Patients With Psoriatic Arthritis: Pooled Safety Analysis of Three Phase 3, Randomized, Controlled Trials. Adewale Adebajo, Philip Mease, Arthur Kavanaugh, Dafna Gladman, Juan GomezReino, Jürgen Wollenhaupt, Maurizio Cutolo, Georg Schett, Eric Lespessailles, Kamal Shah, ChiaChi Hu, Randall Stevens, Christopher Edwards, Charles Birbara PP217 Inflammatory Bowel Disease associated arthropathy: characteristics of the disease and validity of diagnoses based on ICD-coding in Sweden. Panagiota Drivelegka, Nikolaos Papachrysos, Ingemar Petterson, Ann Bremander, Lennart Jacobsson PP218 Disease severity as measured by PROMs or need for second line treatment in Inflammatory Bowel Disease associated arthropathy: comparison to other Spondyloarthritis subgroups. Panagiota Drivelegka, Nikolaos Papachrysos, Ingemar Petersson, Ann Bremander, Lennart Jacobsson PP219 Comparison of nonradiographic axial spondyloarthritis and ankylosing spondylitis patients – baseline characteristics and development of clinical variables during three years of anti-tnf therapy in clinical practice. Johan A. Karlsson, Meliha C Kapetanovic, Ingemar F Petersson, Pierre Geborek, LarsErik Kristensen PP220 The Use of the mSASSS Method by Different Specialists. 35 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Julija Zepa, Inita Bulina, Vladimirs Lavrentjevs, Santa Kadike, Liene NikitinaZake, Aivars Lejnieks, Daina Andersone PP221 Hyaluronan is related to TNF in patients with Ankylosing Spondylitis. Daniel Hedqvist, Urban Hellman, Lan Do, Björn Sundström, Solveig Wållberg-Jonsson OP18/PP222 Aortic regurgitation is common in ankylosing spondylitis and justifies routine echocardiographic screening. Eva Klingberg, Bente Grüner Sveälv, Meta Scharin Täng , Odd Bech-Hanssen, Lennart Bergfeldt, Helena Forsblad-d’Elia Modern imaging – clinical and molecular OP20/PP223 Magnetic Resonance Imaging-Assessment of Early Response to Certolizumab Pegol in Rheumatoid Arthritis: a Randomized, Double-Blind, PlaceboControlled Phase IIIb Study Applying Magnetic Resonance Imaging at Weeks 0, 1, 2, 4, 8 and 16. Mikkel Østergaard, Lennart Jacobsson, Christopher Schaufelberger, Michael SejerHansen, Johannes Bijlsma, Anna Dudek, Maria Rell-Bakalarska, Fabienne Staelens, Robert Haake, Britt Sundman-Engberg, Henning Bliddal PP224 Trabecular bone score in patients with rheumatoid arthritis. Vladyslav Povoroznyuk, Tetiana Karasevska, Roksolana Povoroznyuk, B. AubryRozier, Didier Hans 36 PP225 Influence of glucocorticoids on trabecular bone score in patients with rheumatoid arthritis. Vladyslav Povoroznyuk, Tetiana Karasevska, B. Aubry-Rozier, Nataliia Dzerovych, Roksolana Povoroznyuk, Didier Hans OP19/PP226 The diagnostic utility of hand & wrist fluorescence optical imaging in evaluating active synovitis. Yogan Kisten &, Noemi Györi, Hamed Rezaei, Anna Karlsson, Erik af Klint, Ronald van Vollenhoven PP227 Dual Energy CT (DECT) imaging of tophi and monosodium urate deposits in a patient with longstanding anorexia nervosa. Jóhan Petur Weihe, Melanie B. Morillon, Jess Lambrechtsen, Inger Marie Jensen Hansen OP21/PP228 Diagnostic utility of musculoskeletal ultrasound in patients with suspected arthritis – a probabilistic approach. Hamed Rezaei, Søren Torp-Pedersen, Erik af Klint, Yogan Kisten, Noémi Györi, Ronald F. van Vollenhoven PP229 Wholebody and conventional magnetic resonance imaging for assessing inflammation and structural damage in psoriatic arthritis and axial spondyloarthritis. René Panduro P. Poggenborg, Susanne Juhl Pedersen, Iris Eshed, Inge Juul Sørensen, Ole Rintek Madsen, Jakob M Møller, Mikkel Østergaard and Copenhagen Center for Arthritis Research www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden PP230 Mri of the hand and wrist as a tool for detection of joint damage in early rheumatoid Kristina Forslind, Björn Svensson Life-style factors and intervention in rheumatic diseases PP231 Comparison of a 12-Week Partly Supervised Exercise Programme Versus a Self-administered Exercise Programme for Patients With Newly Diagnosed Rheumatoid Arthritis. Trine Seneca, Ellen Margrethe Hauge, Thomas Maribo OP15/PP232 To which extent may the familial risk of rheumatoid arthritis be explained by established RA risk factors? Xia Jiang, Thomas Frisell, Johan Askling, Lars Klareskog, Lars Alfredsson, Henrik Källberg OP16/PP233 Parity and severity of ACPA-positive/-negative rheumatoid arthritis. Results from the Swedish EIRA study. Mitra Pikwer, Cecilia Orellana, Henrik Källberg, Andreas Pikwer, Carl Turesson, Lars Klareskog, Lars Alfredsson, Saedis Saevarsdottir, Camilla Bengtsson PP234 Screening and Simple Counselling Affected Traditional Cardiovascular Risk Factors in Patients with Early Rheumatoid Arthritis. Johan Isaksson, Solveig Wållberg-Jonsson, Gerd-Marie Alenius, Anna Södergren PP235 Smoking functions as a negative regulator of IGF-1 levels and adipokine net- www.scr2014.se work in patients with rheumatoid arthritis. Maria Bokarewa, Malin Erlandsson, Roberto Doria Medina, Sofia Töyrä Silfverswärd, Andreea Ioan-Facsinay PP236 An outsourced health-enhancing physical activity program for people with rheumatoid arthritis. Feasibility, adherence and response The PARA 2010 study. Birgitta Nordgren, Cecilia Fridén, Ingrid Demmelmaier, Gunnar Bergström, Ingrid Lundberg, Alyssa Dufour, Christina Opava and The PARA study group PP237 Smoking cessation in patients with rheumatic disease. Marie-Louise Karlsson, Susanne Pettersson, Ingrid Lundberg PP238 Effect of exercise and life style interventions on an outpatient rehabilitation program for patients with OA in hip(s) or knee(s). Inger Tollefsrud, Ellen Askmann PP239 Development of a Web and Mobile Application to Support Physical Activity in Rheumatoid Arthritis: Results from the Second Step of a Co-design Process. Åsa Revenäs, Christina H. Opava, Ingrid Demmelmaier, Christina Keller, Pernilla Åsenlöf PP240 The Swedish Exercise Self-Efficacy Scale (ESES-S): reliability and validity in a rheumatoid arthritis population. Thomas Nessen, Ingrid Demmelmaier, Birgitta Nordgren, Christina H Opava 37 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden PP241 Serum 25-hydroxyvitaminD below 75 nmol/L in 75% of healthy Swedish adults during 75% of the year. Eva Klingberg, Göran Oleröd, Jan Konar, Max Petzold, Ola Hammarsten PP246 Comparison of Lymphomas in Pri- Inflammatory systemic diseases – immunological mechanisms and clinical phenotypes PP247 Sex ratio of offspring born to PP242 Detection of antinuclear antibod- PP248 Initial symptoms of sarcoidosis ies – a comparison of indirect immunefluorescence on HEp-2 cells and fluoroenzymeimmunoassay (EliA CTD screen, Thermo Fisher). Lone Nørgård Troelsen, Søren Jacobsen can be neurological – A Case Story. Jon Henriksen, Karen Ege Olsen, Rasa Ramoskiene, Inger Marie Jensen Hansen OP13/PP243 CD28null T cells are myotoxic to autologous muscle cells from patients with polymyositis. Jayesh Pandya, Paulius Venalis, Lubna Al-Khalili, Mohammad Hossain, Vanessa Stache, Ingrid E Lundberg, Vivianne Malmström, Andreas Fasth PP244 Autoantibodies against high mobility group box protein-1 in systemic lupus erythematosus: association with disease activity and other antinuclear antibodies. Christopher Sjöwall, Lina Wirestam, Jonas Wetterö, Lars Ottosson, Erik Sundberg, Thomas Skogh, Hanna Schierbeck PP245 Development of IgG Antibodies to Streptavidin may Explain a Case of False Positive Autoantibody Screening Test for Connective Tissue Disease (CTD). Pernille Hurup Duhn, Thor Skovsted, Bjarne Kristensen, Henning Locht 38 mary and Secondary Sjögren’s Syndrome. Lilian Vasaitis, Gunnel Nordmark, Johan Askling, Karin Ekstrom.Smedby, Carin Backlin, Christer Sundström, Elke Theander, Eva Baecklund women with lupus. Elizabeth Arkema, Jane Salmon, Julia F Simard PP249 Maternal and Fetal Outcomes in Pregnant Systemic Lupus Erythematosus Patients: An Incident Cohort from a Stable Referral Population Followed During 1990–2010. Iris Marie Jakobsen, Rikke Bek Helmig, Kristian Stengaard-Pedersen PP250 Angiogenesis Factors – Markers for Paraneoplastic Rheumatic Syndromes. Ieva Talijûniené, Paulius Venalis, Jolanta Dadoniené, Algirdas Venalis, Jorg Distler, Ingrid Lundberg, Rita Rugiené PP251 High serum levels of IFN-λ1/3 and IFN-α characterize two separate subgroups among SLE patients. Vilija Oke, Johanna Gustafsson, Susanna Brauner, Agneta Zickert, Iva Gunnarsson, Elisabet Svenungsson PP252 An NFKB1 Gene Promoter Polymorphism is Associated with Primary Sjögren’s Syndrome. www.scr2014.se Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Gunnel Nordmark, Lilian Vasaitis, Elke Theander, Marika Kvarnström, Svein Joar Johnsen, Johan G Brun, Malin V Jonsson, Christopher Sjöwall, Helena Forsbladd’Elia, Marie Wahren-Herlenius, Roald Omdal, Roland Jonsson, Maija-Leena Eloranta, Per Eriksson OP14/PP253 Interferon (IFN)-λ1/3, but not IFN-α, is a marker of poor response to treatment in lupus nephritis. Agneta Zickert, Vilija Oke, Ioannis Parodis, Elisabet Svenungsson, Iva Gunnarsson PP254 Work ability in patients with polymyositis and dermatomyositis: an explorative and descriptive study. Malin Regardt, Elisabet Welin Henriksson, Jan Sandqvist, ingrid Lundberg, Marie-Louise Schult PP255 Activated T cells Enhance the Interferon-α Production by Plasmacytoid Dendritic Cells Stimulated by RNA containing Immune Complexes. Dag Leonard, Maija-Leena Eloranta, Niklas Hagberg, Olof Berggren, Karolina Tandre, Gunnar Alm, Lars Rönnblom PP256 Indirect Immunoflourescence On Hep-2 Cells Versus ELIA CTD Screen For The Detection Of Anti-Nuclear Antibodies. Trine Korsholm, Anne Troldborg, Berit Dalsgaard Nielsen PP257 Increased levels of thrombin activatable fibrinolysis inhibitor correlate with complement activation in patients with the antiphospholipid syndrome. Aleksandra Antovic, Anna Vikerfors, Elisabet Svenungsson www.scr2014.se PP258 T cell subsets profile in peripheral blood from idiopathic inflammatory myositis patients. Fabricio Espinosa, Karina De Anda, Diana Gomez PP259 Decreased disease activity and corticosteroid usage and no renal flares during belimumab treatment in patients with Systemic Lupus Erythematosus. Ioannis Parodis, Elisabet Svenungsson, Magnus Axelsson, Iva Gunnarsson PP260 Microcirculation and macrovascular disease in systemic sclerosis – a nailfold capillary study. Annica Nordin, Lena Björnådal, Evangelia Roubi, Kerstin Jensen-Urstad, Elisabet Svenungsson PP261 Effect of Single-Nucleotide Polymorphisms on Type I Interferon Production by Plasmacytoid Dendritic Cells Stimulated with SLE-Associated Immune Complexes. Olof Berggren, Andrei Alexsson, Karolina Tandre, Ann-Christine Syvänen, Lars Rönnblom, Maija-Leena Eloranta PP262 A new method to evaluate the extent of pulmonary fibrosis in patients with Systemic sclerosis. Evangelia Roubi, Sven Nyrén, Lena Björnådal, Elisabet Svenungsson, Annica Nordin PP263 Characterization of histidyl-tRNA synthetase specific Th cell response in blood and bronchoalveolar lavage (BAL) cells of myositis patients. Inka Albrecht, Eddie James, Maryam Fathi, Maryam Dastmalchi, Jessica Herrath, 39 Scandinavian Congress of Rheumatology 2014. 20–23 September 2014 Stockholm Sweden Karine Chemin, Jan Wahlström, Johan Grunewald, Vivianne Malmström, Ingrid Lundberg PP264 Diagnostic Value of ANA and ENA Among Patients with Paraneoplastic Rheumatic Syndromes. Giedré Kapleryté, Rita Rugiene, Jolanta Dadoniene, Eduardas Aleknavicius, Jorg Distler, Algirdas Venalis, Paulius Venalis PP265 An uncommon Cause for Dyspnoe. Beate Fiene, Michael Fiene PP266 Epilepsy in Systemic lupus erythematosus (SLE). Liisa Hopia, Magnus Andersson, Elisabet Svenungsson, Fredrik Piehl, Torbjörn Tomson Adolescent rheumatology PP269 Bone Mineral Density and Predictors Thereof in a Population Based Cohort of Individuals with Juvenile Chronic Arthritis 17 Years after Disease Onset. Lennart Bertilsson, Boel Andersson Gäre, Anders Fasth, Ingemar F Petersson, Helena Forsblad-d’Elia PP270 Socioeconomic Consequences of Juvenile Chronic Arthritis; A PopulationBased Study 22 Years after Disease Onset. Lennart Bertilsson, Boel Andersson Gäre, Anders Fasth, Ingemar F Petersson, Helena Forsblad-d’Elia PP267 Proteomics and metabolomics in the classification of SLE subsets. Per-Johan Jakobsson, Elisabet Svenungsson, Helena Idborg, Peter Nilsson, Craig Wheelock, Iva Gunnarsson, Johan Trygg, Janne Lehtiö, Ina Schuppe Koistinen and “Identification of sub-phenotypes and biomarkers in systemic autoimmune diseases”, an academic Karolinska-AstraZeneca joint program. PP268 Renal Microangiopathy in SLE with Renal Involvement – a Biopsy Study. Jakob Gerhardsson, Birgitta Sundelin, Leonid Padyukov, Agneta Zickert, Elisabet Svenungsson, Iva Gunnarsson 40 www.scr2014.se Pfi ze sy r-s m po po n si so um re d 22nd September, 17.00–18.00 Congress Hall A, Stockholm City Conference Centre, Sweden Aspects of axial SpA Deep dive into the key data on prevalence, diagnosis and management of the disease 17.00 Welcome and introduction Professor Lennart Jacobsson (Sweden) 17.05 Axial SpA in Sweden: Prevalence, co-morbidities and patient-reported outcomes Professor Lennart Jacobsson 17.20 Therapies for non-radiographic axial SpA: From clinical trials to clinical practice Professor Maxime Dougados (France) 17.40 MRI in the non-radiographic axial SpA patient Associate Professor Lars Erik Kristensen (Sweden) 17.55 Questions and closing remarks Professor Lennart Jacobsson Date of preparation: September 2014 ENB20140819PSE01 Chair: Professor Lennart Jacobsson A programme funded and sponsored by Pfizer. Inc. All rights reserved. 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