Australasian College of Toxicology and Risk Assessment 7th Annual SCIENTIFIC MEETING Early Meeting Notice, Call for Papers and Registration Crowne Plaza, Coogee Beach Sydney NSW Wednesday 8th October 2014 - Workshop “Advances to Alternative Methods for Toxicology in Chemical Health Risk Assessment” Prof. Mark Cronin, Liverpool John Moores University, England Thursday 9th and Friday 10th October 2014 7th Annual Scientific Meeting Prominent speakers: Emeritus Professor Beverly Raphael Dr Harold Willaby Conference themes: •R isk Perception and Risk Communication Professor Simon Chapman •A ir Pollution Professor Guy Marks • Nanoscience Professor Lidia Morawska • Other submitted papers We are seeking abstract submissions from researchers, practitioners and government professionals. Why present at the ACTRA ASM? Presenting a paper at the ACTRA ASM is an opportunity for you to: • share your research findings and field experiences • build your personal and company profile as a knowledge leader in your field of expertise, • n etwork with your peers during the event, • m eet other academics and specialists from other disciplines and find a broader audience for your work, • b e influential in setting the agenda in your sector, and • have your contribution read by a wide online audience. Who will attend? The ACTRA ASM should attract attendance by toxicologists (academic, industry and government), epidemiologists, environment health risk assessments professionals, analytical service providers, consultants, contractors, engineers, environmental managers, financiers, hydrogeologists, industrialists, legal practitioners, local government officers and officials, policy makers, property owners and developers, regulators, researchers, scientists, site auditors, site operators, technology providers and urban planners. The “bluesalt” Experience on the 9th October 2014. bluesalt Restaurant offers an extensive menu of innovative modern Australian cuisine, featuring the freshest local seafood, meat and produce. We are offering a full dining experience, including alcohol, predinner canapés, share platter followed by three course meal. How to submit a paper Your abstract can be up to one A4 page in length, no more than 200 words and needs to clearly state the objectives and content of your proposed contribution. It may include figures, tables, diagrams and illustrations but not photos and the file size cannot be any more than 2 MB. When you are sending your abstract, please include the following information in your covering email: • the paper title—please keep this as brief as possible so that it will fit into the limited space allowance of the printed program • your name or the name of a suitable contact person • your company or organisation name • your email address Please submit your abstract by email to [email protected] by Friday 8th August 2014 What happens next? You will be notified in mid-September 2014 whether or not your abstract has been accepted into the program. If it is an accepted presentation, the title will be included in the published preliminary program and the abstract will be published in the event booklet. If you have any queries, please do not hesitate to contact us. Kind regards, ACTRA Secretariat Karoline Willis Ph 0423 082 521 40 Hoddle St Robertson NSW 2577 [email protected] www.actra.org.au ARE YOU INTERESTED IN ATTENDING? Please register your interest with our secretariat by clicking HERE a 40 Hoddle St Robertson NSW 2577 p +61 2 423 082 521 e [email protected] w www.actra.org.au One Day Workshop: “Advances To Alternative Methods For Toxicology In Chemical Health Risk Assessment” Prof. Mark Cronin, Liverpool John Moores University, England Session 1: P rinciples of Integrated Testing Strategies as a mechanism to reduce/replace animal testing for toxicity evaluation of chemicals • Principles of Integrated Testing Strategies (ITS) and Integrated Approaches to Testing and Assessment (IATA) • - Definition of an AOP. Concepts underpinning the AOP, how they are developed, recorded and evaluated. Relationship between the AOP for an effect or endpoint and the ITS. - Definition of ITS and IATA. Context within which they were developed and are used. • Information within a ITS - Type of information that may be considered within an ITS. Sources of information. Principles of Adverse Outcome Pathways (AOPs) • Using ITS and Assigning Confidence for Prioritisation, Classification and Labelling and Risk Assessment - Concept of differing levels of confidence. When high confidence may be assigned to an ITS evaluation Session 2: F rom in vivo to in silico: How and why computational toxicology can be used to reduce/replace animal testing • Principles of computational toxicology • Applications for regulatory purposes - Definition of (Quantitative) Structure-Activity Relationships ((Q)SARs).Linkage between chemistry and toxicology. Appropriate endpoints for computational models. • Focus on grouping and read-across - Use of computational methods by regulatory agencies worldwide. How computational methods are applied. • Available computational toxicology tools - Examples of freely available (e.g. OECD QSAR Toolbox, ToxTree, OncoLogic) and commercially available (e.g. DEREK Nexus, MultiCASE) computational tools for predicting toxicity. - Methods to form a group (or category). Performing read-across. Strengths and weaknesses. Session 3: From in vivo to in vitro: Principles for in vitro testing, status of tools validation for different hazard endpoints • Principles of in vitro testing for toxicology - Introduction to in vitro methods. Principles of development. Relationship of in vitro methods to the key events defined by an AOP. Defining the relationship from in vitro to in vivo. • Validation of in vitro methods • Current status of validation for in vitro methods - Overview of in vitro methods under validation. Status of in vitro methods as realistic alternatives for toxicity tests. • Extending in vitro toxicology to 21st Century Toxicology - Principles for validation of in vitro methods. Agencies (ECVAM, ICCVAM, JACVAM etc) involved. - Introduction to 21st Century Toxicology. Implementing information from AOPs, mechanisms of action and biokinetics to predict hazard. Session 4: A pplying ITS principles to assess the skin sensitisation hazard of chemicals: current status and future directions • An ITS decision tree for skin sensitisation • AOP for skin sensitisation - Using information in a logical manner to make a decision e.g. existing knowledge, in silico predictions and profiling, in vitro test results. - Mechanism of action of skin sensitisation. Definition of the OECD AOP for skin sensitisation. • Mapping in silico and in vitro approaches onto the skin sensitisation AOP • Future of ITS for skin sensitisation - In silico models for the molecular initiating event e.g. for protein reactivity and for sensitisation itself. In vitro models for the key events in the AOP e.g. DPRA, HCLAT, dendritic cells. a 40 Hoddle St Robertson NSW 2577 p +61 2 423 082 521 - Implementing the ITS. Further improvements. e [email protected] w www.actra.org.au ACTRA 7th Annual Scientific Meeting (ASM) Wednesday 8th to Friday 10th October 2014 Registration Form/Tax Invoice This form becomes a Tax Invoice (ABN 26 970 065 392) on completion – please keep a copy. All prices are in AUD and include GST. Please complete all details and return to ACTRA (details below). Delegate Badge name_____________________________________________________________________________________________________ Job title_________________________________________________________________________________________________________ Institution________________________________________________________________________________________________________ Address_________________________________________________________________________________________________________ ________________________________________________________________________________________________________________ City_________________________________________________ State____________________Postcode___________________________ Country _________________________________________________________________________________________________________ Telephone ____________________________________________ Fax________________________________________________________ E-mail __________________________________________________________________________________________________________ Include name/institute on delegate list? Yes Cost ($/ delegate) Students Member 550 300 Non Member 680 400 Member 350 200 Non Member 470 Member Activity No PAYMENT Cheque Please make your cheque payable to: Australasian College of Toxicology and Risk Assessment. Bank transfer Please transfer funds in Australian dollars to: National Australia Bank Account Name Australasian College of Toxicology and Risk Assessment Inc BSB 083 153 Account no. 79647 6337. 300 Credit card (we accept Visa/Mastercard/AMEX) Please note: Visa, Mastercard and Amex transactions incur a $4 transaction fee. 350 200 Non Member 470 300 Thursday night dinner 120 120 I authorise Australasian College of Toxicology and Risk Assessmentto charge the total amount on the credit card, details of which are provided on this form. My signature is for this authorisation. I acknowledge that Australasian College of Toxicology and Risk Assessmentis not required to produce a copy of a signed and validated sales voucher to obtain payment. Member 680 300 Name on card _________________________________________________________ Non Member 850 400 Expiry Date / Thursday night dinner 120 120 Member 800 350 Non Member 1000 500 ASM (2 days)* WS/training (1 day) ASM (1 day) ASM (1 day) & WS (1 day) ASM (2 days)* & WS (1 day) Card Number ________________________________________________________ Signature _____________________________________________________________ *Two day ASM registration includes dinner on Thursday Early Bird registration 10% off total cost by 1 September 2014. Groups of ten (10) or more from the same organisation additional 10% if registrations are received and paid by 27 June 2014 Special requests, eg allergies, food requirements, etc _________________________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________________________ [email protected] – www.actra.org.au ARE YOU INTERESTED IN SPONSORING? Please contact Peter DiMarco on [email protected] Any enquiries please contact the secretariat, Karoline Willis at [email protected] Ph 0423 082 521 40 Hoddle St Robertson NSW 2577