IVAL-BHTC ADMET Tutorial Series IVAL Boston Hepatocyte Technology Center 389 Main Street, Malden, MA Toxicology and Drug Development About ADMET Tutorial Series The focus of IVAL-BHTC ADMET tutorial series is to provide expert tutorials on stateof-the art drug discovery and development science and technology, with emphasis on drug metabolism, drug-drug interactions, and toxicology. Toxicology and Drug Development is the inaugural ADMET tutorial to be presented by Professor A. Wallace Hayes, co-editor of “Hayes' Principles and Methods of Toxicology, 6th edition.” Professor Hayes is a prestigious internationally-renowned toxicologist with extensive industrial experience. This two-day course will provide attendees with an overview of the key concepts of November 4th & 5th 2014 toxicology in drug development, experimental protocols for preclinical and clinical safety studies, data interpretation, and safety assessment. Dr. Albert P. Li, an internationally renowned expert on in vitro drug evaluation, will join Dr. Hayes to lecture on in vitro approaches to evaluate adverse drug properties. Toxicology and Drug Development is intended for scientists and professionals from pharmaceutical companies, academic institutions, regulatory agencies, and contract research organizations who are interested in an updated overview of the science and practice of toxicology in drug development. Lecture Syllabus and Timetable Lecture Titles Tuesday Nov 4th 10 am to 5 pm Wednesday Nov 5th 9 am to 4:30 pm Principles and scientific concepts of toxicology Absorption, metabolism, disposition, and excretion of administered drugs Lecturer Hayes Hayes Lunch Break Mechanism of action of toxic drugs Experimental protocols for toxicological evaluation in drug development Hayes Hayes Dose-response relationship and risk assessment Translational biology and toxicology Hayes Hayes Lunch Break In vitro approaches to evaluate adverse drug effects: Drug-drug interactions In vitro approaches to evaluate adverse drug effects: Drug toxicity Class discussion In Vitro ADMET Laboratories | 9221 Rumsey Road | Columbia, MD 21045 [email protected] (410) 869-9037 www.invitroadmet.com Li Li Hayes and Li Toxicology and Drug Development Dates: November 4th & 5th 2014 Page |2 Faculty A. Wallace Hayes, Ph.D., D.A.B.T., FATS, FIBiol, FACFE, FACN, ERT, CNS Dr. Hayes is a toxicologist with over 35 years of experience in industry and academics. He is a Senior Science Advisor at Spherix Consulting, providing strategic, scientific and regulatory guidance. Dr. Hayes lectures at Harvard University and also holds an appointment with the School of Public Health, University of Massachusetts, Amherst as a Research Professor. Dr. Hayes is the Editor-in-Chief, Food and Chemical Toxicology, and has authored more than 200 peer reviewed publications, is the coeditor of Hayes' Principles and Methods of Toxicology, 6th Edition, Human and Experimental Toxicology, Cutaneous and Ocular Toxicology, and co-editor of the Target Organ Toxicity Series. Albert P. Li, Ph.D. Dr. Li is the President, CEO and co-founder of In Vitro ADMET Laboratories LLC. His research is focused on the development and application of humanbased in vitro experimental models, especially primary cultured human hepatocytes, in the accurate assessment of human drug properties including metabolic fate, drug-drug interactions and drug toxicity. Dr. Li was one of the first scientists to successfully cryopreserve human hepatocytes to retain properties of freshly isolated cells, and the inventor of the patented Integrated Discrete Multiple Organ Co-culture (IdMOC) system, which allows cells from multiple organs to be interconnected to emulate an entire organism. Dr. Li has published approximately 160 research papers/book chapters/reviews and edited/coedited 6 books in toxicology, drug metabolism, and cell biology. In Vitro ADMET Laboratories | 9221 Rumsey Road | Columbia, MD 21045 [email protected] (410) 869-9037 www.invitroadmet.com Toxicology and Drug Development Dates: November 4th & 5th 2014 Page |3 General Information The IVAL Boston Hepatocyte Training Center (IVAL-BHTC) is conveniently located in downtown Malden, Massachusetts, USA. The facility is within walking distance from the Massachusetts Bay Transportation Authority. www.mbta.com. Please reference the map insert. Directions for mass transit: take the Orange line to Malden Center. When exiting the Malden Center station, cross Commercial Street at the light. This will put you directly in front of the Malden Government Center. As you face the building, turn left and walk to Pleasant Street and take a right. Follow Pleasant Street to Main Street. We are across the Main Street at the “City Center” Building – 389 Main Street, 3rd Floor, Malden, MA. Parking: Jackson Street Garage, located on Jackson Street between Centre Street and Exchange Street or CBD Garage located on Middlesex Street, between Centre Street and Exchange Street, Malden MA 02148. Parking Rates: Per Hour: $2.00 Daily Rate: $18.00 Early Bird: $6.00 (entry before 9:00 AM, exit before7:00 PM) Payment: Payment may be made by check or credit card. Checks should be made in US dollars, payable to “In Vitro ADMET Laboratories, LLC. “ Submit your completed registration form and preferred method of payment to Nola Mahaney: [email protected] or Mail: IVAL, LLC; 9221 Rumsey Road, Suite # 8, Columbia, MD 21045, USA FAX: (410) 869-9034. Cancellation Policy: All cancellations are subjected to a $100.00 cancellation fee. Greater than 30 days, 100% refund (less cancellation fee). Less than 30 days, no refund, but registration may be transferred to another person. All refund requests must be in writing. All refunds will be issued after the meeting has occurred. No refunds requests will be accepted after November 3rd, 2014. Please submit cancellation and refund requests including registration transfer details to: Fax: 410-8699034; E-mail: [email protected] Academic/Government participants will receive a 50% discount. A larger version of this map is available on request Hotel Accommodations: We recommend Hyatt Place Boston/Medford: 116 Riverside Avenue Medford, Massachusetts, USA, 02155 Tel: +1 781 395 8500 http://bostonmedford.place.hyatt.com They have shuttle service to the T stops on an asneeded basis from 7:30 am-9:00 pm each day. In Vitro ADMET Laboratories | 9221 Rumsey Road | Columbia, MD 21045 [email protected] (410) 869-9037 www.invitroadmet.com Toxicology and Drug Development Dates: November 4th & 5th 2014 Page |4 Registration Information To register, please fill out the following form and submit with your selected form of payment by November 3rd, 2014. Please note: seating is limited and will be assigned on a firstcome, first-served basis. For multiple registrations, please provide the following information for each person. Academic/Government participants will receive a 50% discount. EARLYBIRD DISCOUNT: Save over 10% if you register by October 17th. Preferred form of payment: PO Number: _______________________________ Credit Card (AmEx, Visa, MC): __________________ Number: ________________________________ Security Code: ___________________________ Name on the Card: ________________________ Please check: November Hepatocyte Workshop: (Monday Expiration Date: __________________________ (full day) and Tuesday (am), Nov 3rd and 4th) $485 per person; $435 by Oct 17th Total Amount: $_____________________________ Toxicology and Drug Development short Signature: _________________________________ course registration: (Tuesday and Wednesday, Nov 4th and 5th) $485 per person; $435 by Oct 17th Billing Address: _____________________________ Both workshop and course: $800 per person (Save $170); $700 by Oct 17th __________________________________________ __________________________________________ Billing Contact Name / Phone Number: (Please print legibly) __________________________________________ Name: ____________________________________ __________________________________________ Job Title: __________________________________ Submit this completed form to: Company: _________________________________ Email: Nola Mahaney, [email protected] Fax: (410)-869-9034 Address 1: _________________________________ Address 2: _________________________________ City / ST / Zip: _______________________________ Mail: IVAL, LLC; 9221 Rumsey Road, Suite # 8, Columbia, MD 21045, USA E-mail: ___________________________________ Phone: ___________________________________ In Vitro ADMET Laboratories | 9221 Rumsey Road | Columbia, MD 21045 [email protected] (410) 869-9037 www.invitroadmet.com
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