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CV - Søren-Peter Olesen
Work address
Phone
E-mail
Web
Private address
Education
1979
1982
1988
1989
The Danish National Research Foundation
Holbergsgade 14, 1057 Copenhagen K, Denmark
+45 33 18 19 52; +45 20 28 97 06 (cell phone)
[email protected]
www.dg.dk; www.ionchannel.ku.dk ; www.darc.ku.dk
Emiliekildevej 43, 2930 Klampenborg, Danmark
MSc (elec.engineer.; civilingeniør), Danish Technical University
MD, University of Copenhagen
Internship, Rigshospitalet
PhD (dr.med.), University of Copenhagen
Previous positions
1982-86
Research assistant/PhD student, Dept. Med. Physiol., University of Copenhagen
1986-87
Postdoc, Brigham & Women's Hospital, Harvard Med. School, Boston, USA
1987-89
Internship, Dept. of Medicine, Surgery, Ophthalmology, Copenhagen Hospitals
1989–98
Head of Department, NeuroSearch A/S
1998Professor of Physiology, Department of Biomed Sci, University of Copenhagen
2005-2015
Director of the Danish National Research Foundation Centre for Cardiac Arrhythmia
2008-2015
Head of the Section of Cardiovascular Research, Dept. Biomed. Sci., U. Copenhagen
2015Director of the Danish National Research Foundation
The Royal Danish Academy of Sciences and Letters
1998Member
2005-08
Member of the Science Policy board
2009-11
Secretary General
Publications
Published >160 papers in international peer reviewed journals including Nature, PNAS, Circulation,
Physiological Reviews about ion channels, arrhythmia, cardiovascular- and neuro-physiology. h-factor is 48.
Co-inventor on 25 issued international patents on new chemical compounds, biological principles, and
technological inventions for electrophysiological characterization of drug effects.
Grants
The Danish Medical Research Council. Framework grants from 1998-present. PI
The Danish National Research Foundation Center for Cardiac Arrhythmia. 2005-15. PI
Innovationfund Denmark. Grant no 65-2013-3. 2014-18. Co-PI.
The Lundbeck Foundation, The NovoNordisk Foundation, The Danish Heart Foundation, The Velux
Foundation a.o. continuous support from 1998-2015. PI
EU Marie Curie Actions: Coordinator and/or participant in Science Grant SC1*CT91-0665; Biomed 2
project BMH4-97-2118; FP7, Marie Curie, ITN, PITN-GA-2009-2357
Teaching and supervision
Teach medical, dentistry, medtech, human biology students in cell biology, physiology and pharmacology.
Have supervised 39 PhD students
Scientific conferences
Give 2-4 invited talks and co-organize 1-2 international conferences in Copenhagen each year.
Boards
Member of the board of the Carlsberg Foundation, 2012Member of the board of the Scandinavian Physiological Society, 2010-2015
Member of Fagligt Udvalg, Danish Ministry of Higher Educations and Science, 2009-2015
Chairman of committees for international guest scientist housing in the Danish National Bank (2002- ) and in
The Nordea Foundation (2009- )
Industry
Member of the supervisory board of The Carlsberg Group A/S, 2012Member of the Board of Directors of Sophion Bioscience A/S, 2001-11
Co-founder of Sophion Bioscience and Poseidon Pharma 2001-2, CEO of Poseidon 2002-4
Consultant to NeuroSearch A/S, 1998-2012
Consultant to Acesion Pharma A/S, 2013-15
Chairman of the committee making the university-industry collaboration strategy at U Cph, 2009-10
Chairman of the University of Copenhagen patent and licensing supervisory board 1998-2007
Selected publications from Søren-Peter Olesen – 21 out of 168 papers
Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia
N Schmitt, M Grunnet, SP Olesen
Physiological Reviews 94 (2), 609-653, 2014
Very early-onset lone atrial fibrillation patients have a high prevalence of rare variants in genes previously
associated with atrial fibrillation
MS Olesen, L Andreasen, J Jabbari, L Refsgaard, S Haunsø, SP Olesen, ...
Heart Rhythm 11 (2), 246-251, 2014
Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction
proteomics
A Lundby, EJ Rossin, AB Steffensen, MR Acha, C Newton-Cheh, ...
Nature Methods, 11 (8), 868-74, 2014
A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation
MS Olesen, L Refsgaard, AG Holst, AP Larsen, S Grubb, S Haunsø, ...
Cardiovascular Research 98 (3), 488-495, 2013
Familial aggregation of lone atrial fibrillation in young persons
N Øyen, MF Ranthe, L Carstensen, HA Boyd, MS Olesen, SP Olesen, ...
Journal of the American College of Cardiology 60 (10), 917-921, 2012
Downregulation of Kv7. 4 channel activity in primary and secondary hypertension
TA Jepps, PS Chadha, AJ Davis, MI Harhun, GW Cockerill, SP Olesen, ...
Circulation 124 (5), 602-611, 2011
Identification of a Kir3. 4 mutation in congenital long QT syndrome
Y Yang, Y Yang, B Liang, J Liu, J Li, M Grunnet, SP Olesen, ...
The American Journal of Human Genetics 86 (6), 872-880, 2010
Arvelige hjertesygdomme forårsaget af natriumkanalmutationer
J Tfelt-Hansen, SP Olesen, JH Svendsen, T Jespersen
Ugeskr Læger 171 (15), 1261-5, 2009
Single-copy insertion of transgenes in Caenorhabditis elegans
C Frøkjær-Jensen, MW Davis, CE Hopkins, BJ Newman, JM Thummel, ...
Nature Genetics 40 (11), 1375-1383, 2008
hERG1 channel activators: a new anti-arrhythmic principle
M Grunnet, RS Hansen, SP Olesen
Progress in Biophysics and Molecular Biology 98 (2), 347-362, 2008
Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1, 3-bis-(2hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)
RS Hansen, TG Diness, T Christ, J Demnitz, U Ravens, SP Olesen, ...
Molecular Pharmacology 69 (1), 266-277, 2006
The KCNQ1 potassium channel: from gene to physiological function
T Jespersen, M Grunnet, SP Olesen
Physiology 20 (6), 408-416, 2005
Pharmacological characterization of small‐conductance Ca2+‐activated K+ channels stably expressed in HEK
293 cells
D Strøbæk, TD Jørgensen, P Christophersen, PK Ahring, SP Olesen
British Journal of Pharmacology 129 (5), 991-999, 2000
Inhibition of T cell proliferation by selective block of Ca2+-activated K+ channels
BS Jensen, N Ødum, NK Jørgensen, P Christophersen, SP Olesen
Proceedings of the National Academy of Sciences 96 (19), 10917-10921, 1999
Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase
SP Olesen, J Drejer, O Axelsson, P Moldt, L Bang, JE Nielsen‐Kudsk,…
British Journal of Pharmacology 123 (2), 299-309, 1998
Cloning, expression, and distribution of a Ca 2+-activated K+ channel beta-subunit from human brain
J Tseng-Crank, N Godinot, TE Johansen, PK Ahring, D Strøbaek, R Mertz, ...
Proceedings of the National Academy of Sciences 93 (17), 9200-5, 1996
Selective activation of Ca2+-dependent K+ channels by novel benzimidazolone
SP Olesen, E Munch, P Moldt, J Drejer
European Journal of Pharmacology 251 (1), 53-59, 1994
Haemodynamic shear stress activates a K+ current in vascular endothelial cells
SP Olesen, D Clapham, P Davies
Nature 331 (6152), 168-170, 1988
Free oxygen radicals decrease electrical resistance of microvascular endothelium in brain
SP Olesen
Acta Physiologica Scandinavica 129 (2), 181-187, 1987
A calcium-dependent reversible permeability increase in microvessels in frog brain, induced by serotonin
SP Olesen
The Journal of Physiology 361 (1), 103-113, 1985
Electrical resistance of brain microvascular endothelium
C Crone, SP Olesen
Brain Research 241 (1), 49-55, 1982
Selected issued international patents from Søren-Peter Olesen – 7 out of 25 patents
Administering 1, 3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea activates an ERG channel; arrhythmia;
cardiac ishemia, ischemic heart disease, hypertrophic heart, cardiomyopathia or failing heart
SP Olesen, M Grunnet, P Christophersen, D Strøbæk, J Demnitz, ...
US Patent 7,851,492; 2010
Benzimidazol-2-one derivatives and their use
LS Madsen, C Ærteberg Bæk, A Lauridsen, SP Olesen
US Patent 7,244,756; 2007
PCR measurement system
T Jespersen, SP Olesen, M Bech, R Taboryski
European Patent 1,511,843; 2002
Bis (benzimidazole) derivatives serving as potassium blocking agents
BS Jensen, SP Olesen, L Teuber, D Peters, D Strøbæk
US Patent 6,194,447; 2001
A substrate and a method for determining and/or monitoring electrophysiological properties of ion channels.
JW Petersen, P Telleman, O Hansen, P Christophersen, M Bech, SP Olesen …
US Patent 6,682,649; 1999
Patch clamp apparatus and technique having high throughput and low fluid volume requirements.
SP Olesen & P Christophersen
US Patent 6,063,260; 1994
Urea derivatives and their use.
SP Olesen, P Moldt & O Pedersen
US Patent 5,696,138; 1993