1. health and fitness
2. disease

FORSKNINGENS DAG
27. august 2015
Program og abstracts
Hospitalsenheden Vest
Center for Forskning og Uddannelse
folder.indd 1
25/08/15 14:40
Session 1 - Orale præsentationer
Chair: Erling Bjerregaard Pedersen og Annette Haagerup
Nr.
1
Tid
13.05-13.17
2
13.17-13.29
3
13.29-13.41
4
13.41-13.53
5
13.53-14.05
6
14.05-14.17
7
14.17-14.29
Titel på præsentationen
Incidence of Traumatic Spinal Cord
Injury in Denmark, 1990-2012: A
Hospital-based Study
High prevalence of Hypertension in a
Danish Population
Narrow band imaging ved fleksibel
cystoskopi
Effectiveness of physiotherapy
exercises for patients with difficulty
returning to usual activities 8-12 weeks
after decompression surgery for
subacromial impingement syndrome: a
randomised controlled trial
One-Stop Clilnical Pathway for the preoperative evaluation and treatment of
trigger finger and carpal tunnel
syndrom.
Infantile Colic: Risk factors and
developmental outcomes
Navn
Bodil Bjørnshave Noe, Sygeplejerske,
cand.scient.san, Ph.d. Seniorforsker,
CFU
Nikolaj Hoffmann-Petersen, Læge,
ph.d. stud. Medicinsk Forskning
Ditte Drejer, Læge, phd. stud.
Urinvejskir.
David Høyrup Christiansen,
Fysioterapeut, cand. scient.san., ph.d.
Forsker, AMK
Relatives experience of writing diaries
for critically ill. A phenomenologicalhermeneutical study.
Anne Højager Nielsen
Sygeplejerske, Master Klinisk
Sygepleje,
Ph.d. stud., Intensiv afd.
Anke Elisabeth de Beijer, MSc ph.d.
stud. Ortopæd.
Ioanna Milidou, Læge ph.d.
Perinatal Epidemiology Research Unit,
AUH
Inviteret foredrag
14.30-15.00
Kliniske databaser v/ Eva Natalia Glassou, cand. Scient. san., PhD-stud. Kvalitet og
Udvikling, Hospitalsenheden Vest
Side 1 af 38
Session 2 – Poster præsentationer
Chair: Johan Hviid Andersen og Bodil Bjørnshave Noe
Nr.
8
Tid
15.30-15.35
9
15.35-15.40
10
15.40-15.45
11
15.45-15.50
12
15.50-15.55
13
15.55-16.00
14
16.00-16.05
15
16.05-16.10
16
16.10-16.15
17
16.15-16.18
16.18-16.25
Titel på præsentationen
Use of analgesics and psychotrophics
following threats and violence at work
in human service sectors
PROLUC – PatientRapporterede
Outcomemål for LUngeCancer
Navn
Karin Biering, fysioterapeut, cand.
scient.san., ph.d. Forsker, AMK
Neurological symptoms, evaluation and
treatment in Danish patients with
achondroplasia and hypochondroplasia
Obstructive sleep apnea and blood
pressure and in patients with
hypertension and chronic kidney
disease
Socioeconomic differences in
educational attainment among young
adults- the role of social relations. A
prospective cohort study.
Handling of the Hemoclot Thrombin
Inhibitor assay reagents on Sysmex CS2100i when monitoring dabigatran in
acute clinical situation
Return to work after stroke
Mia Doherty BA medicin
Forskningsmedarbejder CSS,
Børneafdeling A, AUH og CFU, HEV
Bodil Gade Hornstrup, læge ph.d. stud.
Universitetsklinik for Nyresygdomme
og Hypertension, Holstebro
The International Donor 7042 NF1
Offspring Registry
Suspected Impingement Syndrome –
prevalence of radiographic findings and
their relation to the
Oxford Shoulder Score
Tværfaglig klinisk uddannelse i et
ambulatorium
Pause
Side 2 af 38
Ida Zerlang, projektsygeplejerske,
Onkologisk afd.
Trine Nøhr Winding, fysioterapeut,
cand. scient.san., ph.d.
Forsker, AMK
Louise Faaborg,
Forskningsbioanalytiker, KBA
Louise Pape Larsen, sygeplejerske,
cand. scient.san., ph.d.stud. AMK
Cecilie Ejerskov Pedersen, Læge
ph.d.stud Børneafd. og AUH
Linda Christie Andrea, Læge, ph.d.
stud. AMK/Ortopæd
Flemming Jakobsen
Uddannelseskonsulent, ph.d
Ortopædkirurgisk Forskningsafsnit
Session 3 – Orale og poster Præsentationer
Chair: Mogens Rørbæk Madsen og Ole May
Orale præsentationer
Nr.
18
Tid
16.25-16.37
19
16.37-16.49
20
16.49-17.01
21
17.01-17.13
22
17.13-17.25
Titel på præsentationen
The Effect of Sodium Nitrite on Central
and Peripheral Hemodynamics,
Vasoactive Hormones, GFR and Sodium
Excretion in Healthy Subjects
Accuracy of Adenosine 2D Strain Stress
Echocardiography in the detection of
Coronary Artery Disease in patients with
Chest Pain
Effects of Violence Prevention Behavior
on Exposure to Workplace Violence and
Threats: A Follow-up Study
10-years follow-up on incontinence
after hysterectomy compared to
controls.
Stress som et sociokulturelt fænomen
Navn
Jeppe Bakkestrøm Rosenbæk, Læge,
Klinisk assistent, Medicinsk Forskning
June Anita Ejlersen, Læge
Nuklearmedicinsk Afdeling
Charlotte Ann Gadegaard,
psykolog, phd. stud. AMK
Ulla Christiansen, Læge ph.d. stud.
Gynækologisk-obstetrisk Afdeling
Tanja Kirkegaard, Psykolog, ph.d. AMK
Poster præsentationer
Nr.
23
Tid
17.25-17.30
24
17.30-17.35
25
17.35-17.40
26
17.40-17.45
Titel på præsentationen
Loop recording (R.Test Evolution 4) in 7
days detects more patients with atrial
fibrillation compared to a 2 day Holter
recording in patients with ischemic
stroke or transient ischemic attack
Measured changes in serial dead space
during modification of pressure support.
Treatment of hypertension using
telemedical home blood pressure
measurements
Metronomic chemotherapy seams to be
less toxic than conventional
chemotherapy. Preliminary results from
the XeNa trial for breast cancer
patients
Navn
Michala Herskind Sejr, Læge ph.d.
Kardiologisk afd.
Nilanjan Dey, Overlæge,
Anæstesiologisk Afdeling
Nikolai Hoffmann-Petersen, Læge,
ph.d. stud. Medicinsk Forskning
Søren Linnet, Overlæge Onkologisk
Inviteret foredrag
17.45-18.30
Publikation af lægemiddelforskning
v/ Niels Holmark Andersen overlæge dr. med. AUH
Side 3 af 38
Abstrakt nr. 1
Incidence of Traumatic Spinal Cord Injury (TSCI)in Denmark, 1990-2012: A
Hospital-based Study
Navn:
Bodil Bjørnshave Noe
Sygeplejerske, cand scient san, ph.d.
Seniorforsker
HEV-CFU
[email protected]
24 94 65 84
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
The annual average incidence of TSCI in Europe has risen during the past 30
years. Most countries have seen an increase in age at time of injury,
percentage of tetraplegia and incomplete lesions.
Data on incidence, prevalence and cause of injury are critical to prevention
and planning of clinical and community services.
This study aims to assess the incidence of TSCI and TSCI incidence trends in
relation to cause, age, gender, level and completeness of injury.
Metoder og materiale:
Resultater:
Konklusion:
Øvrige forfattere
TSCI patients admitted between 1990 and 2012 to Spinal Cord Injury Centre of
Western Denmark. Proportions, incidence rates and incidence rate ratios
were calculated for five time-periods; and were stratified on age, gender,
cause, level and completeness of TSCI.
Included were 691 patients (males 81.9%). The overall annual TSCI incidence
was 10.2 per million person-years at risk. Median age at time of injury rose
from 29.0 to 47.5 years. The proportion of transport-related injuries fell, fallrelated injuries rose and the proportion of incomplete tetraplegia increased.
The overall TSCI incidence is low and remained stable from 1990 to 2012.
Patients aged above 60 years at time of injury who sustain an incomplete
tetraplegia caused by fall-related injury are a present challenge to
rehabilitation team at hospital and in the community.
Ellen Margrethe Mikkelsen1, MPH, PhD, Senior Researcher
Rikke Middelhede Hansen2 , MD
Mathias Thygesen13 , Medical Student
Ellen Merete Hagen2,4 , MD, PhD, Associate Professor
1
2
3
4
Hvordan er projektet
finansieret:
Department of Clinical Epidemiology, Aarhus University Hospital,
Aarhus Denmark
Spinal Cord Injury Centre of Western Denmark, Viborg Denmark,
Spinal Cord Research Center Aarhus University Hospital, Denmark
Department of Clinical Medicine, University of Bergen, Norway
Projektet er støttet med 25.000 d.kr fra intern forskningspulje i
Hospitalsenhed Midt i Viborg.
Side 4 af 38
Abstrakt nr. 2
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
High prevalence of Hypertension in a Danish Population
Nikolai Hoffmann-Petersen
Læge, Ph.D. studerende
HU-læge nefrologi
Medicinsk afdeling, Holstebro
[email protected]
29464510
Home blood pressure (HBP) is prognostically superior to office blood pressure
(OBP) ans similar to ambulatory blood pressure measurements. We
determined the prevalence of hypertension using HBP with telemedical data
transmission in the municipality of Holstebro (57000 citizens).
Metoder og materiale:
Using the Civil Registration System, we invited citizens aged 55-64 years to
have their OBP and HBP measured. Elevated OBP was defined as ≥140/90
mmHg. HBP was measured 3 times daily on 3 consecutive days with 3
measurements on each occasion. HBP was the mean of all measurements on
day two and three, and hypertension was defined as ≥135/85 mmHg.
Resultater:
We included 3102 citizens. Group 1: (n=1464, 47%) had both normal OBP and
HBP. Group 2: (n=838, 27%) had both elevated OBP and HBP indicating
persistent hypertension. Group 3: (n=560, 18%) had elevated OBP and normal
HBP indicating white coat hypertension. Group 4: (n=240, 8%) had normal
OBP but elevated HBP indicating masked hypertension.
Konklusion:
This is the first study to eliminate completely reporting bias by using
telemedical transmission of blood pressure data. One third of citizens in the
age group 55-64 years had an abnormally HBP, and one fourth either had
either white coat hypertension or masked hypertension.
Øvrige forfattere
T. Lauritzen, J.N. Bech & E.B. Pedersen
Eventuelle vejledere
T. Lauritzen, J.N. Bech & E.B. Pedersen
Hvordan er projektet
finansieret:
Tryg Foundation, Municipality of Holstebro and Central Denmark Region
Side 5 af 38
Abstrakt nr. 3
Navn:
Titel:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Narrow band imaging ved fleksibel cystoskopi
Ditte Drejer/Jørgen Bjerggaard
Reservelæge og PhD stud./Professor og overlæge
Urinvejskirurgisk Afd, Holstebro og Aarhus Universitet Hospital
[email protected]
28919283
Narrow Band Imaging, NBI er en ny optisk teknik, der giver en maximal
kontrast af strukturerne i blæreslimhinden, hvilket muliggør en bedre
detektion af ikke-muskel invasiv blærecancer eller forstadier til blærekræft
sammenlignet med standard hvidt lys.
Formålet er, at undersøge i hvor høj en grad anvendelsen af NBI ved
flexcystokopi bedrer diagnostikken og ændrer den kliniske beslutning ved
såvel primær hæmaturiudredning som ved kontrol skopier.
Metoder og materiale:
1140 patienter blev inkluderet i perioden maj 2014 til juni 2015 på de
involverede urologiske afdelinger. Cystoskopien blev foretaget først på
normal vis med hvidt lys og den kliniske beslutning noteret. Herefter blev
blæren undersøgt med NBI og den samme eller ændrede kliniske beslutning,
blev noteret.
Resultater:
Der var positive fund i hvidt lys i 216 HD skopier (22,6%). Ved disse patienter
blev der fundet yderligere patologi i 61 skopier ved brug af NBI (28,2%). De
cystoskopier, hvor der ikke blev fundet patologi i hvidt lys, blev der fundet
suspekte forandringer i NBI ved 25 skopier (3,4%). Samlet set blev den kliniske
beslutning ændret i 9 %.
Konklusion:
Ved anvendelse af NBI som supplement til hvidt lys i forbindelse med fleksibel
cystoskopi kan påvises yderligere patologiske forandringer i blæreslimhinden.
Øvrige forfattere
Jørgen Bjerggaard Jensen, Professor og overlæge.
Urinvejskirurgisk Afdeling, Aarhus Universitets Hospital og Hospitalsenheden
Vest, Holstebro
(Gitte Lam, Overlæge, Herlev Hospital)
(Søren Høyer, Overlæge, AUH)
Eventuelle vejledere
Hvordan er projektet
finansieret:
1/3 PhD løn fra HEV
Side 6 af 38
Abstrakt nr. 4
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Effectiveness of physiotherapy exercises for patients with difficulty
returning to usual activities 8-12 weeks after decompression surgery for
subacromial impingement syndrome: a randomised controlled trial
David Høyrup Christiansen
Fysioterapeut, ph.d.
Post doc/forsker
Dansk Ramazzini Center, Arbejdsmedicinsk Klinik, Universitetsklinik
Regionshospitalet Herning, Hospitalsenheden Vest
[email protected]
21 68 84 31
Little is known about the effectiveness of different exercise programmes
following subacromial decompression surgery.
The study aimed to evaluate the effectiveness of a standardized
physiotherapy exercise intervention after decompression surgery for
subacromial impingement syndrome.
Metoder og materiale:
A total of 126 patients with difficulty returning to usual activities 8-12 weeks
after surgery were randomised to receive either a standardised
physiotherapy exercise intervention or usual care. At three months, the
primary outcome was the Oxford Shoulder Score. Secondary outcomes were
the Constant Score and the Fear Avoidance Beliefs Questionnaire.
Resultater:
Intention-to-treat analyses demonstrated a non-significant treatment effect
of 2.0 (95% confidence interval -0.5 to 4.6) for the Oxford Shoulder Score. A
significant treatment effect of 6.8 (1.3 to 12.3) was found for the Constant
Score, with more patients in the exercise group showing a clinically relevant
improvement, odds ratio 3.6 (1.6 to 8.5); number needed to treat 3.3 (2.2 to
9.2). Reduction in fear avoidance beliefs displayed a non-significant mean
difference of -1.8 (-3.8 to 0.3) in favour of the exercise group. Per protocol
analyses displayed significantly larger improvement for the exercise group in
primary and secondary outcomes.
Konklusion:
A standardized physiotherapy exercise intervention appears more effective
than usual care for short term improvement.
Øvrige forfattere
Poul Frost overlæge, ph.d., Dansk Ramazzini Center, Arbejdsmedicinsk Klinik,
Aarhus Universitetshospital.
Deborah Falla fysioterapeut, Professor, Pain Clinic Center for Anesthesiology,
Emergency and Intensive Care Medicine University Hospital Göttingen &
Department of Neurorehabilitation Engineering, Bernstein Focus
Neurotechnology (BFNT) Göttingen Bernstein Center for Computational
Neuroscience (BCCN), University Medical Center Göttingen Georg-August
University.
Jens Peder Haahr overlæge, MPH, Dansk Ramazzini Center, Arbejdsmedicinsk
Klinik, Regionshospitalet Herning, Hospitalsenheden Vest
Lars Henrik Frich overlæge, ph.d. Ortopædisk afdeling, Odense
Universitetshospital.
Susanne Wulff Svendsen overlæge, professor, Dansk Ramazzini Center,
Arbejdsmedicinsk Klinik, Regionshospitalet Herning, Hospitalsenheden Vest.
Hvordan er projektet
finansieret:
Projektet er finansieret af Det Strategiske Forskningsråd (sagsnummer: 09066985) og Dansk Ramazzini center.
Side 7 af 38
Abstrakt nr. 5
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Metoder og materiale:
One-Stop Clilnical Pathway for the pre-operative evaluation and treatment
of trigger finger and carpal tunnel syndrom.
Anke de Beijer
MSc
PhD studerende
Ortopædkirurgisk forskningsenhed
[email protected]
3148 3826
Comparison of one stop day-care surgery versus day-care surgery with
preoperative outpatient clinic assessment on: waiting times, patient-related
outcomes (DASH, EQ5-D) and patient satisfaction
Development of a clinical pathway by a multidisciplinary team. Standard care
was updated by using latest medical best practices, other changes:
• Diagnostics and operation on the same day instead of after two visits
• Operation in local anesthesia anesthesia instead of full intravenous
block
• Optimization of in- and outflow of patient in the operating theater
• Standardized diagnostics, communication to patients and between
healthcare staff and standardized post operative protocol
Resultater:
Total in-hospital
waiting time
Time referral- operation
(workdays)
# patient visits
Mean DASH 3 months
post operative
(baseline)
Average # patients per
sitting
Usual Care
median
(range)
216 minutes
(85-466)
55 (5-331)
Clinical pathway
median (range)
P-value
93 minutes (38189)
27 (3-100)
P<0.01
2
37.31
SD16.65
(47.6)
6
1
37.36 SD15.47
(46.73)
P<0.01
P=0.98
11
Patients experienced clinical pathway day as really good (73%, n=178) or good
(20%, n=48).
Konklusion:
One stop day-care surgery reduces total patient waiting time, number of
visits, time from referral to operation without compromising DASH scores.
Øvrige forfattere
Torben Bæk Hansen, professor, ledende overlæge, ortopædkirurgisk afdeling,
Regionshospitalet Holstebro
Maiken Stilling, lektor, læge, PhD, ortopædkirurgisk forskning Aarhus
Lene Dremstrup, overlæge, ortopædkirurgisk afdeling, Regionshospitalet
Holstebro.
Eventuelle vejledere
Torben Bæk Hansen, professor, ledende overlæge, ortopædkirurgisk afdeling,
Regionshospitalet Holstebro
Maurits van Tulder, professor, VU University, Amsterdam, Institute for Work
and Health, VU University Medical Center
Maiken Stilling, lektor, læge, PhD, ortopædkirurgisk forskningsafdeling
Aarhus
Hvordan er projektet
finansieret:
Projektet er finansieret af ortopædkirurgisk forskningsenheden
Side 8 af 38
Abstrakt nr. 6
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Infantile Colic: Risk factors and developmental outcomes
Ioanna Milidou
MD, PhD
Reservelæge
Børneafdelingen, AUH
[email protected]
41592054
Infantile colic consists of unexplained crying during the first months of life
and affects up to 10% of all children. Little is known about the development of
the affected infants after the period with the excessive crying is over.
Metoder og materiale:
Children from the Danish National Birth Cohort (1996-2002) were followed up
during childhood. Children with a history of infantile colic were compared to
peers using the Developmental Coordination Disorder Questionnaire, the
Strengths and Difficulties Questionnaire, and child psychiatric diagnoses
registered in the National Patients Registry.
Resultater:
Children with a history of infantile colic did not have elevated risk for
developmental coordination disorder ( Odds Ratio 1.2 with 95% confidence
interval[1.0-1.6]), scored more often in the abnormal range for emotional (1.4
[1.2-1.6]), conduct (1.4 [1.2-1.6]), inattention/hyperactivity (1.3 [1.1-1.6], and
peer problems (1.3 [1.1-1.5]), and were more likely to be diagnosed with
Attention Deficit Hyperactivity Disorder during childhood (1.3 [1.1-1.6]).
Konklusion:
Children with a history of infantile colic may have more emotional and
behavioural problems, peer problems, and hyperactivity while they have
similar gross and fine motor skills to unaffected peers.
Øvrige forfattere
Charlotte Søndergaard, MD, PhD, Børneafdelingen, HEV
Eventuelle vejledere
Tine Brink Henriksen, MD, PhD, professor, Børneafdelingen, AUH
Hvordan er projektet
finansieret:
Lundbeck Fonden, Region Midtjyllands Sundhedsvidenskabelige
Forskningsfond, Børneafdelingen HEV, Aarhus Universitet
Side 9 af 38
Abstrakt nr. 7
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Relatives experience of writing diaries for critically ill. A
phenomenological-hermeneutical study.
Anne Højager Nielsen
MKS
Intensivsygeplejerske, ph.d. studerende.
ITA, Anæstesiologisk Afdeling
[email protected]
78432600 / 60774422
Diaries written by nurses for the critically ill patient help the relatives cope
and support the patient. Relative’s participation in writing a diary is
appreciated by the patients. However, relative’s perception of writing a diary
has not previously been explored. The aim of this study was to explore how
relatives experience writing a diary for the critically ill patient.
Metoder og materiale:
Seven relatives were interviewed in a phenomenological-hermeneutic study
building on the theory of Ricoeur.
Resultater:
We found that when relatives wrote a diary for the critically patients, they
experienced how writing and reading the diary allowed for the unloading of
emotions and expression of feelings. Writing a diary was a meaningful
activity while enduring a situation of uncertainty. Furthermore it created a
distance that allowed understanding of the critical situation. Relatives used
the diary to communicate their feelings of love for the patient, thus, creating
a feeling of togetherness with the patient or restoring a suffering
relationship. When writing in the diary relatives wished to protect the
patient but also change the patient’s way of life.
Konklusion:
Involving relatives in writing a diary supports relatives and helps them cope
with the critical situation but may also impact the relationship between
relatives and patient.
Eventuelle vejledere
Sanne Angel, Lektor, ph.d.
Institut for Folkesundhed, Sektion for sygepleje, Aarhus Universitet.
Hvordan er projektet
finansieret:
Undersøgelsen var finansieret af Anæstesiologisk Afdeling.
Side 10 af 38
Abstrakt nr. 8
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Use of analgesics and psychotrophics following threats and violence at
work in human service sectors
Karin Biering
Cand.scient.san., ph.d.
Forsker
Arbejdsmedicinsk Klinik
[email protected]
78433500
Exposure to threats and violence at work are common in human service
sectors. Previous studies have shown that threats and violence may have
health consequences, in terms of physical injuries and psychological strain.
A previous cross-occupational study found an association between violence
and use of psychotropics. The aim was to examine the association between
exposure to threats and violence at work in human service sectors and use
of analgesics and psychotropics
Metoder og materiale:
5333 Danish employees working in psychiatry, eldercare, the Prison and
Probation Service and special schools answered questionnaires in 2010 and
followed in a register of medical prescriptions for 3 years. Outcomes were
use of analgetics and psychotropics.
Resultater:
Only few types of threats and violence were associated with use of
medication. Across sectors we found that being held or being bit was
associated with use of analgesics and psychotropics. The self-reported
rating of severity was likewise associated with use of medication, primarily
psychotropics.
Konklusion:
Threats and violence in human service sectors was only to a limited extend
associated with use of analgetics and psychotropics. These negative
findings may be explained by resilience or that the most exposed workers
may have been sick-listed and thus has not answered the questionnaire.
Øvrige forfattere
Lars Peter Sønderbo Andersen, psykolog, ph.d, forsker, Arbejdsmedicinsk
Klinik, Annie Høgh, psykolog og ph.d., professor, Københavns Universitet og
Johan Hviid Andersen, Læge, ph.d., professor, Arbejdsmedicinsk Klinik
Hvordan er projektet
finansieret:
Arbejdsmiljøforskningsfonden
Side 11 af 38
Abstrakt nr. 9
Navn:
Titel:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
PROLUC – Patient rapporterede Outcomemål for lungecancer
Ida Zerlang
Projektsygeplejerske
Onkologisk afdeling
[email protected]
78 43 74 59
Patient Reported Outcome Measures (PROM) er hidtil primært anvendt I
kliniske forsøg. En model for systematisk brug af PROM i klinisk praksis er
afprøvet blandt lungecancer patienter i Danmark, initieret og ledet af
Kræftens Bekæmpelse. Hensigten er at inddrage kræftpatienters
registrering af deres helbredsstatus under behandling.
Metoder og materiale:
Undersøgelsen er et pilotprojekt på lungecancerpatienter i Herning, som
udfylder PROM-skema ved brug af AmbuFlex i forbindelse med ambulant
kontrol hver 3. uge i alt 4-5 gange i løbet af et 12 ugers palliativt
behandlingsforløb. Besvarelserne bliver gennemgået med læge og
sygeplejerske med henblik på optimering af symptomkontrol.
European Organisation for Research and Treatment of Cancer (EORTC) har
udviklet det anvendte spørgeskema (EORTC_QLQ-c30 og LC-13)
Resultater:
I alt er 198 patienter inkluderet, PROM besvarelser; 1. ambulante kontakt
(n=122), 2. kontakt (n=93), 3. kontakt (n=76), 4. kontakt (n=58), 5. kontakt
(n=47). Der er ingen ændring på livskvalitet eller emotionel funktion over tid,
fysisk funktion forbedres lidt over tid men ikke signifikant.
Symptomer/problemstillinger som opleves mest belastende er følgende:
anspændthed, åndenød, fysiske begrænsninger, seksuelt samvær, træthed
og bekymring om forværring og død.
Konklusion:
Ovenstående præliminære data er modtaget fra KB ultimo juni 2015. Vi
forventer at kunne analyse data yderligere til forskningens dag.
Øvrige forfattere
Lars Peter Sønderbo Andersen, psykolog, ph.d, forsker, Arbejdsmedicinsk
Bodil Bjørnshave Noe, Seniorforsker, cand. scient. san, PhD, CFU,
Hospitalsenheden Vest
Halla Skuladottir, Overlæge, Dr. Med. Onkologisk afdeling Hospitalsenheden
Vest
Niels Henrik Hjøllund, Professor, overlæge, PhD Leder af AmbuFlex
Hospitalsenheden Vest
Hvordan er projektet
finansieret:
Kræftens Bekæmpelses PROLUC-projekt er et toårigt projekt og er
finansieret med 1.8 millioner kroner fra KB’s indsamlingen Knæk Cancer
2012. Der indgår 6 onkologiske afdelinger i projektet
Side 12 af 38
Abstrakt nr. 10
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Abstrakt (max 200 ord)
Baggrund og formål:
Neurological symptoms, evaluation and treatment in Danish patients with
achondroplasia and hypochondroplasia
Mia Aargaard Doherty
Stud. Med.
Forskningsmedarbejder
CSS, Børneafdeling A, AUH og CFU, HEV
[email protected]
To investigate the incidence of neurological symptoms and the types of
complications in a cohort of Danish patients with mutation verified
achondroplasia and hypochondroplasia and compare the results with
previously reported findings.
Metoder og materiale:
Retrospective descriptive study by chart review of patients followed in three
outpatients clinics in the period 1997-2014. Forty-eight patients with
achondroplasia with a median age of 9,5 years old and 20 patients with
hypochondroplasia with a median age of 12 years old were enrolled.
Neurologic manifestations, epidemiological variables and clinical data were
collected.
Resultater:
New data on neurological symptoms and surgical interventions were reported
and compared with existing knowledge. Description of phenotypes revealed
frequent headaches, pain in back, neck and lower limbs, sleep apnoea and
conductive hearing loss. No sub-phenotype was predictive for referral to an
MRI scan or neurosurgery.
Konklusion:
Through investigation of phenotypes and genotypes in patients with
achondroplasia and hypochondroplasia we report the frequencies of
neurological symptoms, foramen magnum stenosis, spinal cord compression
and neurosurgery in Danish patients. Variation in the evaluation of patients
among the three clinics is found and discussed. To further standardise the
management of patients, national guidelines for follow-up on children with
ACH and HCH are recommended.
Øvrige forfattere
Doherty MA1,2, Hertel NT4, Hove HB5 and Haagerup A2,3
1.
2.
3.
4.
5.
Centre for Rare Diseases, Department of Paediatrics, Aarhus
University Hospital, Denmark
Centre for Research and Education, Regional Hospital West Jutland,
Denmark
Department of Clinical Medicine, Aarhus University Hospital, Denmark
H.C. Andersen Children’s Hospital, Odense University Hospital,
Denmark
Centre for Rare Diseases, Department of Clinical Genetics,
Rigshospitalet, Denmark
Eventuelle vejledere
Annette Haagerup, Forskningskoordinerende ledende overlæge
Akademisk koordinator, lektor, dr. med. Center for Forskning og Uddannelse
Hospitalsenheden Vest og Institut for Klinisk Medicin Aarhus Universitet,
Health
Hvordan er projektet
finansieret:
Bachelorprojekt, AU Health
Side 13 af 38
Abstrakt nr. 11
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Obstructive sleep apnea and blood pressure and in patients with
hypertension and chronic kidney disease
Bodil Gade Hornstrup
Læge, Ph.D.studerende
Klinisk assistent
Universitetsklinik for Nyresygdomme og Hypertension, Holstebro
[email protected]
61669627
High nocturnal blood pressure(BP) and non-dipping are important prognostic
factors in the risk of cardiovascular disease. Many patients with chronic
kidney disease(CKD) suffer from high nocturnal BP and non-dipping. This may
be related to the presence of obstructive sleep apnea(OSA). In general
population, OSA is observed in 10-15% of men and 5-8% of women,
symptomatic in 2-4%
Metoder og materiale:
238 subjects with hypertension and CKD2 were invited to participate. 70
subjects were included and underwent conventional 24h ambulatoryBP and
centralBP monitoring, 24h urine-collection(microalbuminuria), blood
samples(creatinine), and cardiorespiratory monitoring(AHI). OSA was
diagnosed when AHI>5.
Resultater:
Of the 70 subjects, 27(39%) were diagnosed with OSA(average AHI 16,5). The
subjects suffering from OSA were more obese. There were no difference
between subjects with and without OSA in regard to age, gender, eGFR, ualbumine, number of antihypertensive agents, alcohol intake, Epworthscore.
Subjects with OSA tended to have higher clinicBP, average 24hBP,
nocturnalBP, centralBP, higher frequency of resistant hypertension and nondipping.
Konklusion:
The occurrence of OSA in a population with hypertension and CKD2 was larger
than expected in general population. In subjects with OSA, there was a
tendency towards higher central and brachial BP. It is suggested, that OSA is
the cause of high BP in patients with CKD2.
Øvrige forfattere
Jeppe.B.Rosenbæk, læge, Ph.d.studerende, Nikolai Hoffmann-Petersen, læge,
Ph.d.studerende
Pia.H.Gjørup, Jost Wessels, Thomas Guldager Lauridsen, Erling Bjerregaard
Pedersen, Jesper Nørgaard Bech
900.000 kr. fra Region Midtjyllands Sundhedsvidenskabelige Forskningsfond.
Eventuelle vejledere:
Hvordan er projektet
finansieret:
Side 14 af 38
Abstrakt nr. 12
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Socioeconomic differences in educational attainment among young adultsthe role of social relations. A prospective cohort study.
Trine Nøhr Winding
Cand.scient. san., ph.d.
Forsker
Arbejdsmedicinsk klinik
[email protected]
78433542
It is commonly accepted that parental background factors are associated with
later educational outcome of the off-springs, but to what extent social
relations mediates the association between background factors and
educational attainment is not yet fully understood.
Aim: To investigate the effect of social relations on the association between
parental socioeconomic position and educational attainment.
Metoder og materiale:
This prospective study used data from questionnaires and registers. The
study population consisted of 3054 individuals born in 1989. The outcome
educational attainment was dichotomised into 1. Completed/Still attending
or, 2.Dropped out/Never attended a secondary education at age 21.
Associations between parental socioeconomic position and educational
attainment were analysed, taking into account social relations at age 15 and
18.
Resultater:
Young people from low socioeconomic position families had higher risk of not
completing a secondary education, and the estimates did not change
considerably after adjustment for social relations. However, poor relations
with teachers and classmates at age 18 explained a large part of the
association between income and educational attainment.
Konklusion:
Social relations in general only explained a minor part of the socioeconomic
differences in educational attainment. However, poor relations at school at
age 18 explain a substantial part of the economic inequality in educational
attainment.
Øvrige forfattere
Johan Hviid Andersen, Professor, overlæge, ph.d. Arbejdsmedicinsk Klinik
Hvordan er projektet
finansieret:
Arbejdsmiljøforskningsfonden
Side 15 af 38
Abstrakt nr. 13
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Handling of the Hemoclot Thrombin Inhibitor assay reagents on Sysmex CS2100i when monitoring dabigatran in acute clinical situation
Louise Faaborg
Bioanalytiker
Forskningsbioanalytiker
Klinisk Biokemisk afdeling, Herning
[email protected]
7843 55 00
The Hemoclot Thrombin Inhibitors assay (HTI) has been recommended for
monitoring dabigatran in specific clinical situations. Normally, reagents are
prepared from instructions in the package insert (PI). However, according to
the supplier (Aniara) HTI reagents should be prepared from instructions
found in the application sheet (AS). Aim of this study is to test the onboard
stability of HTI reagents when prepared according to the PI in comparison to
preparation by the AS.
Metoder og materiale:
We compared stability of HTI reagents when prepared according to the PI (15
minutes incubation) and AS (60 minutes incubation) respectively, on a Sysmex
CS-2100i analyzer. Fresh controls were measured four times at baseline and
in duplicate every hour for eight hours consecutively. Accept-criteria: max.
difference of 10 % in results (20 % for C1 Low). Onboard stability: 6 hours
(Hyphen BioMed).
Resultater:
Using the PI, reagents were stable a maximum of 2 hours onboard the
analyzer. Reagents were stable for up to 5 hours when using the instructions
from the AS.
Konklusion:
HTI reagents should not be used more than two hours onboard the Sysmex
CS-2100i when prepared according to the PI. When using the AS reagent
stability increases, but the long incubation time is undesirable in acute
situations.
Øvrige forfattere
Willemijn Comuth, phd stud, Klinisk biokemisk afdeling, Herning.
Anna-Marie Bloch-Münster, Overlæge, Klinisk biokemisk afdeling, HEV.
Linda Ø. Henriksen, Kemiker, Klinisk Biokemisk afdeling, HEV S
teen Husted, Overlæge, Kardiologisk afdeling, HEV
Hvordan er projektet
finansieret:
Fra Klinisk biokemisk afdeling Herning, + Forskningsmidler fra Boehringer
Ingelheim samt 10 % rabat fra Anira på reagenser
Side 16 af 38
Abstrakt nr. 14
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Return to work after stroke
Louise Pape Larsen
Phd.studerende, Cand.scient.san, Sygeplejerske
Phd.studerende
AmbuFlex v. Arbejdsmedicinsk Klinik
[email protected]
78433549 / 61388949
Self-rated health is an essential aspect of life after stroke, and Return To
Work (RTW) is considered one of the most important outcomes for younger
stroke patients. The aim of this study was to examine whether self-rated
health 3 months after stroke is independently associated with RTW and
succeeding work-stability.
Metoder og materiale:
A total of 590 patients aged less than 60 years at the time of stroke and in
occupation or unemployment prior to the stroke were included. Information
on self-rated health (SF12) was collected from questionnaires three months
after stroke. Employment status was defined on a weekly basis using national
register data on transfer payments.
Resultater:
Fifty percent of the patients were self supporting or job-seeking 12 months
after the stroke, and the same proportion was found after 24 months. More
than 70% of the patients, who returned to work during the first year after
stroke, did not receive sickness benefits the succeeding 12 months. High
levels of self-rated health 3 months after stroke were strongly associated
with RTW after 12 and 24 months.
Konklusion:
Self-rated health three months after stroke was strongly associated with
RTW and work-stability after stroke.
Øvrige forfattere
Karin Biering, PhD, Cand. Scient. San, Department of occupational medicine,
Regional Hospital West Jutland, Herning, Denmark
Soeren Paaske Johns MD, phD Department of Clinical Epidemiology, Aarhus
University Hospital, Aarhus, Denmark;
Grethe Andersen MD, DMSc Department of Neurology, Aarhus University
Hospital, Aarhus, Denmark;
Niels Henrik Hjollund Proff, MD, PhD AmbuFlex, Regional Hospital West
Jutland, Herning, Denmark
Eventuelle vejledere
Soeren Paaske Johns MD, phD Department of Clinical Epidemiology, Aarhus
University Hospital, Aarhus, Denmark;
Grethe Andersen MD, DMSc Department of Neurology, Aarhus University
Hospital, Aarhus, Denmark;
Niels Henrik Hjollund Proff, MD, PhD AmbuFlex, Regional Hospital West
Jutland, Herning, Denmark
Hvordan er projektet
finansieret:
2/3 fakultetsstipendie fra AU, Helsefonden og Trygfonden
Side 17 af 38
Abstrakt nr. 15
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
The International Donor 7042 NF1 Offspring Registry
Cecilie Ejerskov
Ph.d.-studerende
Klinisk Assistent
Børneafdeling A, AUH
[email protected]
Kontor 7845 1521 / 2567 3729
The Danish sperm donor number 7042 has fathered several offspring with
neurofibromatosis type 1 (NF1) worldwide. NF1 is caused by loss-of-function
mutations in the NF1 gene and more than 1000 NF1 mutations are identified.
Analysis of the donor sperm demonstrated gonosomal mosaicism with an
intragenic deletion involving exons 15-29 in the NF1 gene.
Metoder og materiale:
At the two Danish reference centres for NF1 patients, we evaluated 23 halfsiblings of the donor. Nine were diagnosed with NF1. DNA was sampled and
analysed. At each visit a registration sheet of clinical characteristics is filled
out by specialists in paediatrics or genetics.
Resultater:
Demographics, clinical signs, development and disease severity are
presented. The severity grade of NF1 progressed from minimal to
mild/moderate within 3 years of follow-up.
Konklusion:
The NF1 phenotype shows great variability in intra- and inter-family
expressivity and to date only two NF1 genotype-phenotype correlations have
been established. This rare possibility of a long-term follow-up of a cohort of
half-siblings with NF1 makes further studies including phenotypic variability
and search for modifier genes possible. To achieve this goal, we have initiated
The International Donor 7042 NF1 Offspring Registry.
Øvrige forfattere
Ejerskov C 1,2,3, Farholt S 1, Jensen UB 4, Haagerup A 2,3
6.
7.
8.
9.
Centre for Rare Diseases, Department of Paediatrics, Aarhus
University Hospital, Denmark
Centre for Research and Education, Regional Hospital West Jutland,
Denmark
Department of Clinical Medicine, Aarhus University Hospital, Denmark
Department of Clinical Genetics, Aarhus University Hospital, Denmark
Eventuelle vejledere
Annette Haagerup, Forskningskoordinerende ledende overlæge
Akademisk koordinator, lektor, dr. med. Center for Forskning og Uddannelse
Hospitalsenheden Vest og Institut for Klinisk Medicin Aarhus Universitet,
Health
Hvordan er projektet
finansieret:
Projektet er initieret af forskerne selv uden finansiering.
Side 18 af 38
Abstrakt nr. 16
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Suspected Impingement Syndrome – prevalence of radiographic
findings and their relation to the Oxford Shoulder Score
Linda Christie Andrea
Læge, ph.d.-studerende
Klinisk assistent
Arbejdsmedicinsk Klinik, Universitetsklinik
[email protected]
61 703 783
Danish patients suspected of impingement syndrome generally have
radiographs of their shoulder before their first consultation with a surgeon.
We aimed to describe the prevalence of radiographic findings of rotator cuffcalcifications, osteoarthritis of the acromioclavicular joint, acromial spurs and
a hooked acromion (Bigliani type 3), on standard radiographs. We
hypothesized that these findings are associated with shoulder disability in
terms of a low Oxford Shoulder Score (OSS).
Metoder og materiale:
We conducted a cross-sectional study of all 1039 patients aged 18-63 years,
who were suspected of impingement syndrome based on the referral letter
and who answered a questionnaire, which included OSS, when seen at one of
six orthopaedic departments in Central Denmark Region during 2011.
Radiographs at time of referral were examined by one of two resident
doctors, who were blinded to symptoms and clinical findings. Data was
analyzed with logistic regression, with mutual adjustment for each
radiographic finding and for sex and age.
Resultater:
Radiographs were available for 853 patients (82.1%) Mean OSS was 28. The
prevalence of radiographic findings was: 25.3% for calcifications, 17.5% for a
hooked acromion, 11.9% for osteoarthritis of the acromioclavicular joint, and
15.1% for spurs. Spurs were associated with a low OSS (OSS<24) with an
adjusted OR of 1.7 (95% CI 1.1-2.6). No association was found between any of
the other radiographic findings and a low OSS.
Konklusion:
One fourth of all patients referred for orthopaedic evaluation on suspicion of
impingement syndrome had rotator cuff calcifications on radiographs. The
calcifications had no significant association with OSS. Spurs were the only
radiographic findings associated with a low OSS.
Øvrige forfattere
Poul Frost, overlæge ph.d. Arbejdsmedicinsk Klinik, Aarhus
Universitetshospital
Kate Schmidt, læge, Ortopædkirurgisk Afdeling, Regionshospitalet Viborg
John Gelineck, overlæge, ph.d., Radiologisk Afdeling, Aarhus
Universitetshospital
Torben Bæk Hansen, professor, ledende overlæge, ph.d., Ortopædkirurgisk
Afdeling, Regionshospitalet Holstebro
Søren Rasmussen Deutch, overlæge, ph.d., Ortopædkirurgisk Afdeling,
Regionshospitalet Randers
Susanne Wulff Svendsen, professor, overlæge, ph.d., Arbejdsmedicinsk Klinik,
Regionshospitalet Herning
Hvordan er projektet
finansieret:
Region Midtjyllands Sundhedsvidenskabelige Forskningsfond
Arbejdsmiljøforskningsfonden
Side 19 af 38
Abstrakt nr. 17
Navn:
Titel:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Tværfaglig klinisk uddannelse i et ambulatorium
Flemming Jakobsen
Uddannelseskonsulent, ph.d
Ortopædkirurgisk Forskningsafsnit
[email protected]
20631797
Fald i antal indlagte patienter giver udfordringer vedrørende klinisk
uddannelse af sundhedspersonale i traditionelle kliniske sengeafdelinger,
hvilket gør inddragelse af ambulatoriefunktion i undervisningen vigtig.
Formål: At undersøge pædagogiske og organisatoriske muligheder for
tværfaglig prægraduat klinisk uddannelse i et ambulatorium.
Metoder og materiale:
I ortopædkirurgisk ambulatorium undersøger og behandler en
medicinstuderende og en sygeplejestuderende selvstændigt tre patienter to
dage om ugen. Der vælges kontrolpatienter med ukomplicerede diagnoser,
gives førvejledning og eftervejledning, hvorefter de studerende er alene med
patienten, men har mulighed for at konsultere en vejleder fra egen profession.
De studerende og vejledere er interviewet ved brug af semistruktureret
fokusgruppe interview samt enkelt interview.
Resultater:
De studerende værdsætter selvstændigheden og det tværfaglige samarbejde.
De er både gode til at arbejde inden for egen profession og til at samarbejde
på tværs af professioner. Ledelse, vejledere og kliniske lektorer finder
projektet spændende og udviklende og der arbejdes kontinuerligt med
videreudvikling af organisatorisk og pædagogisk tilgang. Det vurderes, at der
senere kan arrangeres lignende læringsscenarier, hvor studerende fra
professionerne ergoterapi og fysioterapi vil kunne deltage.
Konklusion:
Tværfaglig klinisk undervisning kan med fordel foregå i et ambulatorium med
stort udbytte for de studerende og det formodes, at metoden, med den
nødvendige tilpasning vil kunne implementeres i flere andre specialers
ambulatorier.
Øvrige forfattere
Torben Bæk Hansen, professor. Ortopædkirurgisk Afdeling
Side 20 af 38
Abstrakt nr. 18
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
The Effect of Sodium Nitrite on Central and Peripheral Hemodynamics,
Vasoactive Hormones, GFR and Sodium Excretion in Healthy Subjects
Jeppe Bakkestrøm Rosenbæk
Læge, ph.d. studerende
Klinisk assistent
Universitetsklinik for Nyresygdom og Blodtryksforhøjelse, HEV og Aarhus
Universitet
[email protected]
78436585
Sodium nitrite (NaNO2) is readily converted to nitric oxide (NO) by enzymes in
vivo and exerts vasodilation. Studies based on NO synthase inhibition
indicates a natriuretic effect of NO. The purpose of the present study was to
examine the effects of NaNO2 on hemodynamics and renal function.
Metoder og materiale:
Twelve healthy subjects were treated, in a randomized order, with placebo
(isotonic NaCl) or one of three doses of NaNO2 40, 120 or 240
micrograms/kg/hour for two hours, while supine and water loaded. Diastolic,
systolic and mean arterial blood pressure (DBP, SBP and MAP), heart rate,
plasma renin, angiotensin-II and aldosterone, GFR by chrome-EDTA clearance,
fractional sodium excretion (FENa), and urinary excretion rate of nitrite and
nitrate (NOx) where measured.
Resultater:
FENa was reduced by 0.25% 95%CI (0.02;0.47) by the lowest dose, 0.24% (0.12;0.59) by the intermediate dose and 0.32% (0.06;0.59) by the highest dose
compared to placebo. The highest dose reduced SBP by 4.5 mmHg (0.5;8.5),
DBP by 3.8 mmHg (0.9;6.7), MAP by 4.0 mmHg (1.2;6.8) and increased P-renin
concentration by 17.6% (2.9;32.2), P-angiotensin-II by 21.8% (4.6;38.9), and
urinary excretion rate of NOx by 95% (59;132) compared to placebo. There
was no effect on heart rate, GFR or aldosterone
Konklusion:
A two hour infusion of 240 microg/kg/hour NaNO2 exerted an antinatriuretic
and BP lowering effect. The rise in urinary NOx suggests an increased
bioavailability. Activation of the renin-angiotensin-aldosterone system (RAAS)
could be mediated directly by nitrite/NO or by baroreceptor reflex. The
antinatriuretic effect may be mediated by the RAAS
Øvrige forfattere
Safa Therwani, ph.d.-studerende, Janni M. Jensen, læge, ph.d., Frank H. Mose,
læge, ph.d.
Eventuelle vejledere
Erling B. Pedersen, overlæge, dr.med., professor og Jesper N. Bech, overlæge,
ph.d., klinisk lektor
Hvordan er projektet
finansieret:
Delfinansieret af offentlige og private fonde
Side 21 af 38
Abstrakt nr. 19
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Accuracy of Adenosine 2D Strain Stress Echocardiography in the detection
of Coronary Artery Disease in patients with Chest Pain
June Anita Ejlersen
cand. med. ph.d. stud.
Overlæge
Nuklearmedicinsk afd.
[email protected]
20285134
Stress echocardiography is a valuable tool for noninvasive investigation of
coronary artery disease (CAD). Global longitudinal strain (GLS) allows
semiautomatic quantification of myocardial deformation from
echocardiograms and facilitates the identification of an abnormal response
during stress.
The purpose of this study was to examine if endocardial GLS (eGLS)
measured from echocardiograms during adenosine infusion could identify
significant CAD in patients with chest pain.
Metoder og materiale:
132 chest pain patients scheduled for invasive coronary arteriography were
consecutively included. All underwent echocardiography with adenosine
stress. The echocardiograms were analysed blinded to the results of the
angiograms which were analysed quantitatively by an experienced
independent reader. The mean (sd) age was 62.6 (9) years and 70 % were
male. Significant CAD (i.e. one or more stenosis above 70%) was present in 44
(33%) of the patients.
Resultater:
No difference in mean (sd) eGLS in patients with/without significant CAD was
found at rest (-22.6 (4.1)% /-23.3 (3.3)%, p=0.27), but a highly significant
difference was detected during adenosine infusion (-23.7% (5.5) / -28.3
(4.1)%, p<0.00001). The area under the curve (AUC) for change in eGLS (eGLS
at rest – eGLS during stress) was 0.79.
Konklusion:
Endocardial GLS measured from adenosine echocardiograms may help to
stratify patients suspected of CAD noninvasively.
Øvrige forfattere
Poulsen SH (kard. afd., Skejby), Mortensen J (NUK, Vest), May O (Kard. Forsk.
Vest)
Eventuelle vejledere
Poulsen SH (kard. afd., Skejby), Mortensen J (NUK, Vest), May O (Kard. Forsk.
Vest)
Hvordan er projektet
finansieret:
Kard. Forskning, Nuklearmedicinsk. afd., RM Fond.
Side 22 af 38
Abstrakt nr. 20
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Effects of Violence Prevention Behavior on Exposure to Workplace Violence
and Threats: A Follow-up Study
Charlotte Ann Gadegaard
psykolog, phd-stud
psykolog, phd-stud
Arbejdsmedicinsk klinik, Herning
[email protected]
61334154
This study investigates the relationship between prevention behaviors
(enacted violence prevention policies) and exposure to workplace violence
and threats across four different high risk work sectors.
Metoder og materiale:
Survey data from a 1-year follow-up sample of 3.016 employees from
psychiatry, special schools, eldercare, and the prison and probation services.
Resultater:
Prevention behaviors are significantly and negatively associated with selfreported exposure to workplace violence and threats – in the prison and
probation services, eldercare, and in psychiatry, while no significant
associations are found for special schools. The results therefore show clear
sector differences with regard to the preventive effect of violence prevention
behaviors. Further, this multi-sector comparison suggests that prevention
behaviors may be more effective in relation to a moderate frequency of
violence and threats, and that only top management prevention behavior may
prevent very frequent incidents (OR=0.58).
Konklusion:
These results imply that when managing workplace violence in high-risk areas
of human service work there should be emphasis on the use of violence
prevention behaviors from top management, supervisor and among coworkers. However, type of sector and the frequency of workplace violence
should be analyzed in order to evaluate the potential impact of prevention
behaviors.
Øvrige forfattere
Annie Høgh, professor, psykolog, PHD, Københavns universitet; Lars Peter
Andersen, psykolog, PHD, arbejdsmedicinsk klinik Herning
Arbejdsmiljøforskningsfonden
Hvordan er projektet
finansieret:
Side 23 af 38
Abstrakt nr. 21
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
10-years follow-up on incontinence after hysterectomy compared to
controls.
Ulla J. Christiansen
Læge og ph.D-studerende
Ph.D-studerende
Gynækologisk Obstetrisk Afd., Regionshospitalet Herning.
[email protected]
28945956
To determine the prevalence of incontinence 10 years after hysterectomy
compared to controls.
Metoder og materiale:
Three cohorts of women consisting of 374 hysterectomised women, 92
women with a laparoscopic cholecystectomy and 201 with a TCER. They have
all answered the same questionnaire concerning urinary incontinence in
2001, 2005 and 2011. Stress incontinence was defined as involuntary leakage
of urine at least once a week when coughing, laughing or lifting. Urge
incontinence was defined as involuntary leakage before reaching the toilet at
least once a week proceeded by an intense desire to void.
Resultater:
The groups were compared to their preoperative status and after 10 years.
Stress incontinence: Of 374 hysterectomies 86% remained continent, 18%
became incontinent, 7% became continent and 7% remained incontinent. Of
293 controls 75% remained continent, 16% became incontinent, 5% remained
incontinent. Urge incontinence: Of 374 hysterectomies 86% remained
continent, 9% became incontinent, 3% remained incontinent. Of 293 controls
87% remained continent, 9% became incontinent, 2% remained incontinent.
There was no statistical significant difference between hysterectomies and
controls or within the groups.
The prevalence of stress- and urge-incontinence were comparable between
the groups preoperatively, and remained comparable 10 years later but
increased.
Konklusion:
There is no significant difference in the distribution of incontinence before
and 10 years after hysterectomy compared to controls. The prevalence of
incontinence is increased over time but hysterectomy is not a risk factor.
Øvrige forfattere
Anne R. Kruse, læge, Gynækologisk Obstetrisk Afd. Regionshospitalet
Herning.
Finn F. Lauszus, overlæge, ass. prof., Gynækologisk Obstetrisk Afd.
Regionshospitalet Herning.
Side 24 af 38
Abstrakt nr. 22
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Stress som et sociokulturelt fænomen
Tanja Kirkegaard
Psykolog, ph.d.
Forsker
Arbejdsmedicinsk Klinik
[email protected]
25136110
Inden for stressforskningen har fokus på, hvorledes personlighedsmæssige
faktorer er med til at forme medarbejderes måde at tænke og handle i forhold
til stress, været central. Formålet med dette studie er at undersøge, hvordan
sociale og kulturelle processer på arbejdspladsen påvirker vores måde at
forstå stress, at vurdere vores arbejdsbetingelser samt påvirker vores måde
at handle i forhold til stress.
Metoder og materiale:
Studiet er et mixed methods studie. To afdelinger på en dansk virksomhed
blev fulgt over et år med 3 spørgeskemarunder og 5 mdrs. feltarbejde. I
spørgeskemaet blev der spurgt ind til medarbejdernes sociale netværk,
arbejdsmæssige betingelser, stressniveau og copingstrategier.
Resultater:
Resultaterne indikerer, at der er gruppeforskelle i den måde medarbejderne
forstår stress, vurderer deres arbejdsbetingelser og håndterer stress, hvor
grupperne varierer i forhold til brugen af individuel tilpasningsstrategi og en
kollektiv ændringsstrategi. Baggrunden skal findes i forskelle i
professionskultur, arbejdsorganisering og fysisk placering. Resultaterne viser
også, at en ikke-støttende ledelse har indflydelse på udviklingen af kollektive
stressprocesser i kollektivt orienterede grupper.
Konklusion:
Kulturen og de sociale relationer har betydning for medarbejderes måde at
tænke og handle i forhold til stress og dermed kan personlighedsmæssige
faktorer ikke alene forklare medarbejderes tanke og handlemønstre i forhold
til stress.
Øvrige forfattere
Svend Brinkmann, professor, Institut for kommunikation, AAU
Eventuelle vejledere
Svend Brinkmann, professor, Institut for kommunikation, AAU
Hvordan er projektet
finansieret:
Projektet er fuldt finansieret af arbejdsmiljøforskningsfonden
Side 25 af 38
Abstrakt nr. 23
Forfatter
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Baggrund og formål:
Loop recording (R.Test Evolution 4) in 7 days detects more patients with
atrial fibrillation compared to a 2 day Holter recording in patients with
ischemic stroke or transient ischemic attack
Michala Herskind Sejr
Læge og ph.d.-studerende
Ph.d-studerende / Klinisk assistent
Medicinsk Afdeling i Herning, Kardiologisk Forskningsafsnit
[email protected]
2190 0543
Atrial fibrillation and atrial flutter (AF) is the most important cardiac cause
in ischemic stroke and transient ischemic attacks (TIA). However, AF is
difficult to detect, and the optimal method for the detection of AF in
stroke/TIA patients without known AF has not yet been defined. The loop
recorder R.Test Evolution 4 is a new device. However, the validity of the R
Test is not yet known.
Aim: To compare the diagnostic value of a 7-day loop recording (R.Test) to a
2 day Holter recording with regard to the detection of AF in a consecutive
population of patients with ischemic stroke/TIA and no known AF.
Metoder og materiale:
Patients with stroke/TIA within the previous week. Inclusion criteria were
age ≥ 60 years. The 2 day Holter recording and the 7 day R.Test was started
simultaneously.
Resultater:
176 patients, mean age 70.5 , Male (57.4%). Holter detected 3 patients with
AF, 1 of them was missed by the R.Test. The 7 day R.Test detected 8
patients with AF, 6 of them after the 2-day Holter period.
Konklusion:
A 7 day R.Test analysis detects signicantly more patients with AF compared
to a 2 days Holter analysis. Clinical implication ;the R.Test analysis is less
resource demanding compared to the Holter method.
Øvrige forfattere
Michala Herskind Sejr , Jens Cosedis Nielsen , Dorte Damgaard , Birgitte
4
1
Forsom Sandal , Ole May
1. Cardiovascular Research Unit, Regional Hospital West Jutland,
Aarhus University
2. Department of Cardiology, Aarhus University Hospital, Skejby
3. Department of Neurology, Aarhus University Hospital, NBG
4. Department of Neurology, Regional Hospital West Jutland
Ole May, Jens Cosedis Nielsen og Dorte Damgaard
Eventuelle vejledere
Hvordan er projektet
finansieret:
1
2
3
Region Midtjyllands Sundhedsvidenskabelige forskningsfond 2012: 300.000
kr. til sygeplejertimer
Hjerteforeningen: 1 års løn, svarer til ca. 550.000 kr
Region Midtjyllands Sundhedsvidenskabelige forskningsfond 2014: 1 million
kr.
Aase og Ejner Danielsens Fond: 100.000 til R.Tests kr.
Familien Hede Nielsens Fond: 25.000 kr.
Snedkermester Sophus Jacobsen og hustru: 20.000 kr.
Side 26 af 38
Abstrakt nr. 24
Navn:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Metoder og materiale:
Measured changes in serial dead space during modification of pressure
support.
Nilanjan Dey
Overlæge
Anæstesi og Intensiv
[email protected]
50314730
Measuring serial dead space (Vds) before and after modification of pressure
support (PS) may be necessary to select optimal level of ventilator support.
As part of our study for understanding patients’ response to changes in PS,
Vds was measured on a breath by breath basis [1].We present measured
changes in Vds due to modification of PS.
The study included 12 patients ventilated on PS. Ethical approval were
obtained from the committee of Mid-Jutland, Denmark. Patient or next of kin
and general practitioners consent was obtained. Each patient was subjected
to a series of up to 2 cm H2O step modifications, beginning with reduction of
PS. Each PS level was maintained for 15 minutes. Airway flow and FeCO2
were continuously measured. VCO2 was determined by synchronizing airway
flow and FeCO2 signals. The flow signal was mathematically integrated to
determine tidal volume (Vt). The product between volume and FeCO2
determined VCO2. Vds was calculated with equation 1, and verified by
calculating Fowler’s method corrected to rebreathed CO2 from patients’
tubing (Vdf) [2, 3].
Vds=Vt-VCO2/(fR-(FeCO2-FiCO2) equation 1
Resultater:
Correlation equations between Vt and serial dead space calculations are
shown in figure 1. Grey circles represent Vds, and blank circles represent Vdf.
The correlation coefficient between both calculations was r=0.93 (p<0.001).
Konklusion:
Vds adequately describes serial dead space calculated by Fowler’s method
corrected to rebreathed CO2. There is a linear relationship between Vt and
Vds. Setting PS to achieve low Vt may reduce the level of Vds.
Øvrige forfattere
Winding R, Nyygard M, Larraza S, Karbing DS, Rees SE
Eventuelle vejledere
Prof Stephen Rees.
Hvordan er projektet
finansieret:
Investigator driven Projekt.
Side 27 af 38
Abstrakt nr. 25
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Treatment of hypertension using telemedical home blood pressure
measurements
Nikolai Hoffmann-Petersen
Læge, Ph.D. studerende
HU-læge nefrologi
Medicinsk afdeling, Holstebro
[email protected]
29464510
Telemonitoring of home blood pressure measurements (TBPM) is a new and
promising supplement to diagnosis, control and treatment of hypertension.
We wanted to compare the outcome of antihypertensive treatment based on
TBPM and conventional monitoring of blood pressure.
Metoder og materiale:
Participants (n=356) were recruited from a prior prevalence study among
citizens aged 55-64 years. Randomised, controlled, unblinded 3 months trial.
In the intervention group, antihypertensive treatment was based on TBPM
with transmission of the measurements and subsequent communication by
telephone or e-mail. In the control group, patients received usual care.
Primary outcome was reduction in daytime ambulatory blood pressure
measurements (ABPM).
Resultater:
In both groups, daytime ABPM decreased significantly. The decrease in
daytime ABPM in the intervention group was systolic/diastolic, -8 ±12/-4±7
mmHg. This did not differ significantly from the control group’s -8±13/-4±8
mmHg. An equal number of participants obtained normaldaytime ABPM, in
the intervention group 17% (31/175) versus control 21% (37/181), p=0.34.
Konklusion:
No further reduction in ABPM or number of patients reaching blood pressure
targets was observed when electronic transmission of TBPM was applied in
the treatment of hypertension by GPs. Thus, as an isolated tool TBPM did not
improve BP control.
Øvrige forfattere
T. Lauritzen, J.N. Bech & E.B. Pedersen
Eventuelle vejledere
T. Lauritzen, J.N. Bech & E.B. Pedersen
Hvordan er projektet
finansieret:
Tryg Foundation, Municipality of Holstebro and Central Denmark Region
Side 28 af 38
Abstrakt nr. 26
Navn:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Metronomic chemotherapy seams to be less toxic than
conventional chemotherapy. Preliminary results from the XeNa
trial for breast cancer patients
Søren Linnet, Overlæge / Trine Dongsgaard, projektsygeplejerske
Onkologisk
[email protected]
78437405
Toxic effects and chemoresistance are major hurdles in breast
cancer chemotherapy. To avoid these problems caused by
traditional chemotherapeutic regimes, a new modality of drug
administration called “metronomic chemotherapy” has emerged.
With metronomic chemotherapy more frequent administration at
lower doses of the drugs is given. This study was designed to
resolve the issue whether treatment according to the metronomic
principle is conventional treatment superior in term of efficacy and
safety
Metoder og materiale:
The patients were metastatic breast cancer patients.
Randomization was made between conventional treatment with
Navelbine Oral 60mg/m2 day 1+day 8 plus Xeloda or
metronomic treatment with Navelbine Oral 50 mg three times a
week plus Xeloda.
Resultater:
120 patients were included, with 43 patients from the Department
of Oncology, Herning. The reported adverse events (AE) in the
conventional versus metronomic arm were calculated for 62
patients.
We found that the frequency of all grades of AE was reduced in the
metronomic treatment arm. Especially important was a reduction
in grade 3 and 4 toxicities, but also a reduced frequency of the
grade 1-2 was seen
Konklusion:
Metronomic treatment seams to be less toxic compared to
conventional treatment. Response rates will be evaluated later.
Øvrige forfattere
Linnet S1, Brems-Eskildsen AS2, Luczak A6, Nielsen HA3, Vestlev
PM5, Jensen BB4, Dongsgaard T1, Jensen CB 2, Neimann J 2, Nygaard
AB3 and Langkjer ST2
1
Oncology Department, Herning Hospital
2
Oncology Department, Aarhus University Hospital
3
Oncology Department, Hillerød Hospital
4
Oncology Department, Esbjerg Hospital
5
Oncology Department, Roskilde Hospital
6
Oncology Department, Aalborg University Hospital
Hvordan er projektet finansieret:
Acknowledgement: The clinical study is supported by Pierre Fabre.
Side 29 af 38
Postere ophængt i Kabaretsalen
Titel på præsentationen
Work-related threats and violence in human service
sectors: The importance of the psycho-social work
environment examined in a prospective study.
Open Access telePRO: a website for patient-initiated tele
patient-reported outcome (telePRO) follow-up in
outpatient clinics
Dit Arbejdsliv Nu
Changes in incontinence, quality of life and body
composition following hysterectomy
Elektronisk Patient Håndbog EPH
Tror far og mor mere på internettet end på lægen?
Association between hospital procedure volume and risk
of revision after total hip arthroplasty: A populationbased study
Life-situation after severe fall or traffic accident
patients´ experiences 1 year after hospital rehabilitation
Navn og afdeling
Lars Peter Andersen Psykolog h. PhD AMK
Liv Marit Valen Schougaard Sygeplejerske,
cand.scient.san
Projektkoordinator AmbuFlex/AMK
Gritt Bennedsen, cand.mag.
Forskningsformidling og kommunikation AMK
Anne Raabjerg Kruse Reservelæge, PhD-stud.
Gynækologisk-obstetrisk Afdeling
Birgitte Thofte Sygeplejerske, MHH, MIL
Tværfaglig efteruddannelseskoordinator
Neurologi og Fysio-ergoterapi
Ida Kangas 1. reservelæge Børneafdelingen,
Herning
Eva Natalia Glassou Cand Scient San, PhDstud. Kvalitet og Udvikling, Hospitalsenheden
Vest
Bodil Bjørnshave Noe, Sygeplejerske,
cand.scient.san, Ph.d. Seniorforsker, CFU
Side 30 af 38
Titel på projektet:
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Work-related threats and violence in human service sectors: The
importance of the psycho-social work environment examined in a
prospective study.
Lars Peter Andersen
Cand. psych. PhD
Psykolog
Universitetsklinikken Arbejdsmedicinsk Klinik, Herning
[email protected]
23460879
Threats and violence at work are major concerns for employees in a many in
human service sectors. Therefore, the purpose of this study is to identify
prospective associations between psycho-social work environment and workrelated threats and violence in four high risk sectors within human service
sectors.
Metoder og materiale:
Based on questionnaire data from 3011 employees working in four sectors:
special schools, eldercare, psychiatric wards and in Prison and Probation
Service, the associations between psycho-social work environment and
work-related violence and threats were studied using a one-year follow-up
design and logistic regression analyses.
Resultater:
Across the four sectors and after controlling for relevant confounders the
analyses showed that high quantitative demands, high emotional demands
and many role conflicts were most strongly associated with both high
frequencies of threats and high frequencies of violence. Furthermore, we
identified that low predictability, low rewards at work, low vertical trust and
low organizational justice are associated with work-related threats and
violence in three out of four sectors. Finally, different sector specific
associations were found.
Konklusion:
The results of the study underline the importance of taking the psycho-social
work environment into account in reducing work-related violence and threats
as a supplement to existing methods.
Øvrige forfattere
Annie Hogh; Professor; Department of Psychology, Copenhagen University,
Copenhagen, Denmark
Karin Biering; Researcher and PhD
Charlotte Gadegaard; Researcher and PhD
Hvordan er projektet
finansieret:
Arbejdsmiljøforskningsfonden
Side 31 af 38
Titel på projektet:
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Open Access telePRO: a website for patient-initiated tele patient-reported
outcome (telePRO) follow-up in outpatient clinics
Liv Marit Valen Schougaard
RN, MHSc
Projektkoordinator
AmbuFlex/Arbejdsmedicinsk klinik
[email protected]
61792004
In telePRO, outpatients report information on health status from home
instead of visiting the outpatient clinic. Typically, telePRO outpatient followup activity is initiated by clinicians. The Open Access term indicates that
contacts are initiated solely by the patient. The aim of this study was to
develop a prototype website to collect telePRO in patient-initiated outpatient
follow-up and link the data with the Danish National Health Website
‘Sundhed.dk’.
Metoder og materiale:
A research team provided inputs to design the prototype website. The team
developed the initial website specifications, constructed the website and
elicited feedback from epilepsy outpatients (n=6), using cognitive
interviewing techniques.
Resultater:
The website was customized for patient use. Patients emphasized the
importance of a user-friendly interface with clear and short information.
Patients were interested in tracking change over time. They found it
conceivable that access to their previously questionnaires could give them a
better understanding of their chronic disease. Patients had few problems
assessing and using the site.
Konklusion:
Preliminary reports suggest that the website could be an efficient method to
collect telePRO in a patient-initiated outpatient follow-up activity. Further
evaluation on the effect of quality of care and patient experiences will be
documented in two parallel PhD projects with quantitative and qualitative
methods.
Øvrige forfattere
Caroline Mejdahl, RN, MNSc, The Research Programme in Patient
Involvement, Aarhus University Hospital, Aarhus
Klaus Hvam Petersen, B. Eng., AmbuFlex, Regional Hospital West Jutland,
Herning,
Niels Henrik Hjøllund, MD, PhD, Professor, AmbuFlex, Regional Hospital West
Jutland, Herning and Department of Clinical Epidemiology, Aarhus University
Hospital, Aarhus
Side 32 af 38
Titel på projektet:
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Dit Arbejdsliv Nu
Gritt Bennedsen
cand. mag.
Forskningsformidling og kommunikation
Arb. Med. Klinik
[email protected]
78433557 / 24654902
Der er et behov for at klæde erhvervsskoleelever på til at begå sig i det
psykiske arbejdsmiljø på deres lærepladser. Hjemmesiden,
www.ditarbejdsliv.nu er udviklet til brug i undervisning i psykisk arbejdsmiljø.
Hjemmesiden består bl.a. af et dilemmaspil, historier fra unge selv og
arbejdsmiljøviden. I oplægget vil vi diskutere, hvilke perspektiver læring via
spil har, samt udfordringerne med ”viden til praksis”.
Metoder og materiale:
Der er anvendt en eksplorativ kvalitativ tilgang, herunder
fokusgruppeinterview og observation. Projektet er baseret på en antagelse
om, at det læringsbegreb, som hjemmesiden er baseret på (experience by
proxy) genererer identifikation og øget refleksion over egen praksis.
Hjemmeside er afprøvet i forbindelse med arbejdsmiljøundervisningen på
grundforløbet indenfor fire erhvervsskolefag. Interviewene fokuserede på
brug, udbytte, forslag til forbedringer og afsøge nye veje til læring.
Resultater:
Resultaterne peger på, at eleverne gennem arbejde med hjemmesiden
reflekterer over egen rolle og praksis i relation til psykisk arbejdsmiljø.
Derudover viser den kvalitative tilgang sig frugtbar i forhold til at undersøge,
hvordan man bedst muligt omsætter viden til praksis.
Konklusion:
Eleverne genererer viden om psykisk arbejdsmiljø og egne reaktionsmønstre.
Potentielt pinlige eller svære personlige situationer bliver afdramatiseret og
skaber fokus på generelle mekanismer på en arbejdsplads frem for et isoleret
problem for den enkelte unge.
Øvrige forfattere
Regine Grytnes, post.doc, Arb.Med.Klinik; Helene Meldgaard Pedersen,
forskningsass., Arb.Med.Klinik
Hvordan er projektet
finansieret:
Arbejdsmiljøforskningsfonden
Side 33 af 38
Titel på projektet:
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Changes in incontinence, quality of life and body composition following
hysterectomy
Anne Raabjerg Kruse
Læge
Reservelæge, PhD-studerende fra 1/9
Gynækologisk-Obstetrisk Afdeling
[email protected]
28575995
Information about the perioperative incontinence following hysterectomy is
limited. The aim of the project is to compare changes in incontinence,
postoperative fatigue, quality of life, physical function, and body composition
in patients who underwent hysterectomy.
Metoder og materiale:
Prospective follow-up study of 108 women with hysterectomy on benign
indication were compared pre- and twice postoperatively. The incontinence
was estimated by questionnaire and quality of life by using the SF-36
questionnaire. The fatigue level was scored on a visual analogue scale and
objective measurements were performed.
Resultater:
In total 43 women reported improvement of their incontinence after
hysterectomy while 10 women reported deterioration of their incontinence.
Preoperative stress incontinence correlated with BMI and urge incontinence
with age. Improvement after hysterectomy in stress incontinence was
associated with younger age. Improvement in urge incontinence was
positively associated with BMI. Fatigue resumed to preoperative levels after
30 days. SF-36 revealed that the modality of ‘Physical Functioning’ and ‘RolePhysical’ remained significant decreased at the end of the study.
Konklusion:
Hysterectomy was associated with improvement of incontinence concurrent
with a slight reduction in physical performance assessed by SF-36 30 days
after surgery. No impairment of performance was found in physical tests at
day 13 and 30 postoperatively.
Øvrige forfattere
Ulla J. Christiansen, Læge, PhD-studerende, Gynækologisk-obstetrisk
afdeling, Herning.
Mogens R. Madsen, Overlæge, Kirurgisk afdeling, Herning.
Finn F. Lauszus, Overlæge, PhD, Gynækologisk-obstetrisk afdeling, Herning.
Hvordan er projektet
finansieret:
Ingen finansiering.
Side 34 af 38
Titel på projektet:
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Elektronisk Patient Håndbog EPH
Birgitte Thofte
Sygeplejerske, MHH, MIL
Tværfaglig efteruddannelseskoordinator
Neurologi og Fysio-ergoterapi
[email protected]
78 43 71 66
Eksplosiv udvikling af kommunikationsteknologi ændrer faglig
kommunikation hastigt. Udviklingsprojektet undersøger patienters
IKT ressourcer, ved at afprøve tabletpc som læringsressource i
hospitalsrehabilitering. Apopleksirehabiliteringens komplekse læreprocesser
lettes bl.a. af personlig motivation, kontinuitet og god koordinering samt
omgivelsernes inddragelse. Målet for dette udviklingsprojekt er: at opstille
krav til en personlig interaktiv, multimodal læringsressource for patienten,
som øger livskvalitet gennem inddragelse, at afdække muligheder/ barrierer
for brug heraf, herunder det tværfaglige personales rolle i at afklare relevans,
og behov for at understøtte, ved brug.
Metoder og materiale:
Udlån af iPads til patienter, der designes inspireret af Life-cycle
proces med forundersøgelse, design, test, evaluering: Teknologi-indkøb,
netværkskrav, opsætning, vedligehold, hygiejne...
Metodisk: blanding af kvalitative og kvantitative data med deltagelse,
deltagerobservation, workshops, interviews og spørgeskemaer.
Konsultationer hos softwareudviklere ud fra udviklet design.
Resultater:
10 mænd/10 kvinder, 44-87 år deltog fra jan 2013- okt 2014. Fund -Patienter:
Udfald, motivation og kompetencer afgørende for brug, 25% brugte egen
enhed. Billedmediet virker, både stills og løbende. Fælles interaktiv
kommunikationsramme giver mere synlige planer og overblik over udvikling i
forløb. Kontinuitet i vanlig social kommunikation understøttes, især tydelig i
længerevarende forløb. Stort støttepotentiale i Hjernefittnes og afasistøtte.
Personale: Faglige vurderinger væsentlige for relevans, IKT kompetencer
afgørende, organisations IKT- muligheder og barrierer betydende for
effektivudveksling.
Konklusion:
Kontinuerlig proces at fokusere på relevante apps der under-støtter
individuel læring: Billedoptagelser, kalenderfunktioner, logbog, information,
Internet og sociale medier, læringsspil og kognitiv træning. Enkelhed er
afgørende, hvorfor væsentligste funktioner er samlet i appdesign. App er
under udvikling i samar-bejde med tidligere apopleksipatient
(http://www.apopleksinet.dk/). Dilemmaer forbundet med samarbejde med
omgivelser: Personaledeltagelse fordrer målrettethed, hvilket kan være en
udfordring for patientudnyt-telse af app. Forventningsafstemning med
pårørende med andre mål og forventninger til ressourcen. Niveau for IKT
kompetencer kræver kontinuerlig dialog om brug. Organisations krav løses via
aftaler/vejledninger for alle inddragne.
Hvordan er projektet
finansieret:
Trygfonden har doneret 420.000. Neurologi og Fysio-ergoterapi har stillet
personaletimer til rådighed i et år (budget 120.000).
Side 35 af 38
Titel på projektet:
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Tror far og mor mere på internettet end på lægen?
Ida Kangas
1. reservelæge
HU læge
Børneafdelingen, Herning
[email protected]
60613041
Brugen af og tilgangen til internettet er eksploderet gennem de senere år og
alle danske familier har i dag adgang til internettet. Internationale studier
viser at forældre ofte søger råd og vejledning om sygdom hos børn på
internettet. De danske forhold om forældres søgning på internettet i
forbindelse med akut syge børn er ikke tidligere undersøgt.
Metoder og materiale:
Spørgeskemaundersøgelse blandt forældre i børnemodtagelsen i Århus og
Herning.
Resultater:
51 forældre deltog. 37% havde søgt information på nettet. 45% af forældrene
angav at de søger generel information om sygdom hos børn på internettet.
Hver måned. Kun 8% søger aldrig information på internettet.
Konklusion:
Der var få deltagere i undersøgelsen. Data viser dog at ca 30% af forældrene
søger information på internettet. Desuden benytter de information fra andre
professionelle som f.eks. pædagoger og sundhedsplejersker i forhold til om
de skal kontakte egen læge eller vagtlæge.
Eventuelle vejledere
Berit Andersen, ledende overlæge, Afdeling for folkeundersøgelser,
Regionshospitalet Randers
Hvordan er projektet
finansieret:
Forskningstrænings projekt
Side 36 af 38
Titel på projektet:
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Association between hospital procedure volume and risk of revision after
total hip arthroplasty: A population-based study within the Nordic
Arthroplasty Register Association Database
Eva Natalia Glassou
Cand Scient San, PhD-studerende
Kvalitetskonsulent
Kvalitet og Udvikling, Hospitalsenheden Vest
[email protected]
7843 8706
The aim was to examine if hospital procedure volume was associated with
the risk of revision after primary total hip arthroplasty (THA) in the Nordic
countries from 1995 to 2011.
Metoder og materiale:
The Nordic Arthroplasty Register Association provided information about
primary THA, revision and annual hospital volume. Hospitals were divided
into volume groups (1-50, 51-100, 101-200, 201-300, >300). Primary outcome
was the cumulative incidence of revision at different time points.
Multivariable regression was used to assess the relative risk (RR) of revision.
Resultater:
417,687 THAs were included. The cumulative incidence of revision increased
from 1.4% (CI 1.3 – 1.5) after 1 year to 9.2% (CI 8.9 – 9.4) after 15 years. After 1
year, no differences were seen between the hospital volume groups. After 10
years, RR for revision were reduced for the four largest volume groups
compared to group 1-50 (51-100: 0.83, CI 0.72 – 0.96, 101-200: 0.79, CI 0.67 –
0.94, 201-300: 0.75, CI 0.60 – 0.95, >300: 0.66, CI 0.54 – 0.80). Same pattern
was seen for both the cemented and uncemented THAs.
Konklusion:
Hospitals operating 50 procedures or less per year had an increased risk of
revision after 2, 5, 10 and 15 years follow up.
Øvrige forfattere
Torben Bæk Hansen, Professor. Department of Orthopedic Surgery, Regional
Hospital West Jutland, Denmark
Keijo Mäkelä, Professor. Department of Orthopaedics and Traumatology,
Turku University Hospital, Turku, Finland
Leif Ivar Havelin, Professor. The Norwegian Arthroplasty Register,
Department of Orthopedic Surgery, Haukeland University Hospital, Bergen,
Norway
Johan Kärrholm, Professor. Institute of Clinical Sciences, Department of
Orthopaedics, Sahlgrenska University Hospital, Gothenburg
Alma Becic Pedersen, Clinical associate professor. Department of Clinical
Epidemiology, Aarhus University Hospital, Denmark
Eventuelle vejledere
Torben Bæk Hansen, Professor. Department of Orthopedic Surgery, Regional
Hospital West Jutland, Denmark
Alma Becic Pedersen, Clinical associate professor. Department of Clinical
Epidemiology, Aarhus University Hospital, Denmark
Hvordan er projektet
finansieret:
EG was funded by the Health Research Fund of Central Denmark Region
during the preparation of the study
Side 37 af 38
Titel på projektet:
Navn:
Titel:
Stilling:
Afdeling:
E-mail:
Telefon/mobil:
Abstrakt (max 200 ord)
Baggrund og formål:
Life-situation after severe fall or traffic accident
patients´ experiences 1 year after hospital rehabilitation
Bodil Bjørnshave Noe
Sygeplejerske, cand scient san, ph.d.
Seniorforsker
CFU
[email protected]
24 94 65 84
Getting on with life following trauma due to severe fall or traffic accident is a
challenging process. Some patients manage well, and some do not. What
supports the rehabilitation process?
We explored spinal cord injured patients´ experiences in order to identify
characteristics of positive and negative overall life-situations 1 year after
hospital-rehabilitation
Metoder og materiale:
Interviews study with seven patients discharged from Vestdansk
Rygmarvsskade Center. Inductive content analysis was used.
Resultater:
Patients´ experiences are characterized by four scenarios with respect to
“clarification in relation to overall life situation” and “threat to core
competences”.
Clarification in combination with threat to core competences may explain
patients´ overall life situation 1 year post-discharge. High degree of
clarification combined with low degree of threat to core competences was
indicative of very positive rehabilitation outcomes. On the other hand, poor
clarification led to a stressful life situation. When core competences can be
transformed into new skills, threats were manageable. “Worst-case” scenario
was characterized by low degree of clarification combined with a high degree
of threat to patients´ competences.
Konklusion:
The present study’s findings enhance the importance for rehabilitation-team
to support clarification and balance threats in order for patients to achieve
positive overall life situations following severe trauma.
Øvrige forfattere
Merete Bjerrum, Associate Professor, PhD
Sanne Angel , Associate Professor PhD
Department of Nursing, Institute of Public Health, Aarhus University,
Denmark
Hvordan er projektet
finansieret:
Projektet er støttet med 35.000 dkr fra intern forskningspulje i
Hospitalsenhed Midt i Viborg. Projektet er gennemført som led i mit
adjunktur fra 2012 til 2014, - et stillingsfællesskab mellem HEM og Sektion for
Sygepleje AU Health finansieret af HEM.
Side 38 af 38
Bodil Bjørnshave Noe
Morten Hollænder Beeck
Annette Haagerup
Janet Hansen
[email protected]
[email protected]
[email protected]
[email protected]
Dorte Bøgested Holdensen
[email protected]
Hospitalsenheden Vest
Center for Forskning og Uddannelse
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