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24 Neuropharmacology Conference 2014| Oral Program
Oral Program
08:00
09:00-09:15
Thursday 13 November 2014
Registration Opens | Cavalier Foyer
Room: Cavalier Room
Introduction
Session Chair :
09:15-10:00
[KEY01] Inhibition allows for segmentation of neuronal information
G. Buzsáki, New York University, USA
Refreshments | Room: Cavalier Foyer
Oral Session 1: Receptor trafficking and anchoring
10:00 -10:30
10:30-12:30
Session Chair :
10:30-11:00 [INV01] Mechanisms that facilitate the selective targeting of GABAARs to axo-axonic synapses
S. J. Moss, Tufts University, USA
11:00 -11:30 [INV02] Regulation of GABAA receptor clustering and trafficking and the tuning of synaptic inhibition
J. Kittler, University College London, UK
11:30-12:00 [INV03] Impaired GABAA receptor biogenesis in genetic epilepsies
R.L. Macdonald, Vanderbilt University Medical Center, USA
12:00-12:15 [ST01] Neuronal activity controls cell surface expression of gabab receptors via endoplasmic
reticulum associated protein degradation
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K.Z. Zemoura* , M.S. Schenkel , M.A. A. Acuña , G.Y. Yévenes , Z.H. Hanns Ulrich , D.B.
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Benke , University of Zurich, Switzerland, ETH zurich, Switzerland
12:15-12:30 [ST02] RNF34 interacts with and promotes GABAA receptor degradation via ubiquitination of the γ2
subunit
H. Jin, T. Chiou, C.P. Miralles, A.L. De Blas*, University of Connecticut, USA
12:30-13:30 Lunch & Poster Viewing| Room: Cavalier Foyer
Session Chair :
13:30 -15:30 Oral Session 2: Inhibitory synaptogenesis
13:30-14:00 [INV04] The GABAergic postsynaptic density mediates signaling that modulates the differentiation
of adult-born olfactory bulb granule cells
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F. Deprez , P. Panzanelli , S.K. Tyagarajan , J-M Fritschy* , University of Zurich, Switzerland, ETH
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and University of Zurich, Switzerland, University of Turin, Italy
14:00-14:30 [INV05] Inhibitory receptor dynamics: deep quantification and chemistry in cellulo
C. Salvatico, C.G. Specht, A. Triller*, Institut de Biologie de l'École Normale Supérieure (IBENS), France
14:30-15:00 [INV06] Neuroligins at inhibitory synapses - from synaptogenesis to autism spectrum disorders
N. Brose, Max Planck Institute of Experimental Medicine, Germany
15:00-15:15 [ST03] Genetic variations lead to differential trajectories of interneuron ontogeny, behavior and
physiological correlates
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G.B. Bissonette , M.R. Roesch , E.M. Powell* , University of Maryland School of Medicine, USA,
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University of Maryland, College Park, USA
15:15-15:30 [ST04] A role for autism-associated cadherin-10 at excitatory and inhibitory synapses
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K.R. Smith* , K.A. Jones , K.J. Kopeikina , A.C. Burette , B.A. Copits , G.T. Swanson , R.J. Weinberg , P.
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Penzes , Northwestern University, USA, University of North Carolina, USA
15:30-16:30 Refreshments & Poster Session| Room: Cavalier Foyer
16:30-18:30 Oral Session 3: Chloride homeostasis: physiology and pathology
Session Chair :
16:30-17:00 [INV07] Regulation of KCC2 by components of excitatory synaptic transmission
V. Mahadevan, M. Woodin*, University of Toronto, Canada
17:00-17:30 [INV08] Developmental expression patterns of KCC2 in the human cortex
K. Kaila, University of Helsinki, Finland
17:30-18:00 [INV09] Variance in the GABAA reversal potential: Signal or noise?
K. Staley*, J. Glykys, V. Dzhala, K. Egawa, Harvard Medical School, USA
18:00-18:15 [ST05] Genetically encoded impairment of KCC2 cotransporter functional regulation in human
idiopathic generalized epilepsy
K.T. Kahle*, N.D. Merner, P. Friedel, Harvard, USA
18:15-18:30 [ST06] Identification of new tools increasing KCC2 function and reducing both spasticity and
neuropathic pain after spinal cord injury
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L. Vinay* , R. Bos , P. Boulenguez , C. Brocard , S. Liabeuf , L. Stuhl-Gourmand , A. Viallat1 ,2 1
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Lieutaud , CNRS, France, Aix Marseille Université, France
18:30
Close of Day 1
th
24 Neuropharmacology Conference 2014| Oral Program
08:00
Friday 14 November 2014
Registration Opens | Cavalier Foyer
Room: Cavalier Room
Oral Session 4: Plasticity of GABA receptors
08:00-10:00
Session Chair :
08:00-08:30 [INV10] Seizure-induced plasticity in the GABAergic control of the HPA axis
J. Maguire, Tufts University, USA
08:30-09:00 [INV11] Molecular insights into the regulation of GABABreceptor signaling
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R. Turecek , T. Fritzius , J. Schwenk , K. Ivankova , G. Zolles , L. Adelfinger , V. Jacquier , V.
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Besseyrias , M. Gassmann , U. Schulte , B. Fakler , B. Bettler* , University of Basel, Switzerland,
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Institute of Experimental Medicine, Czech Republic, University of Freiburg, Germany, BIOSS, Germany
09:00-09:30 [INV12] Probing regulatory mechanisms for GABAA receptors
T.G. Smart*, D. Bright, S. Hannan, D. Laverty, M. Mortensen, B. Patel, P. Thomas, University College
London, UK
09:30-09:45 [ST07] Endocannabinoid-mediated long-term depression of inhibition requires presynaptic protein
synthesis
T.J. Younts*, M.E. Klein, P.E. Castillo, Albert Einstein College of Medicine, USA
09:45-10:00 [ST08] Molecular mechanisms of in vitro and in vivo inhibitory postsynaptic potentiation
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E.M. Petrini , T. Ravasenga , T.J. Hausrat , T.C. Jacob , S.J. Moss , P. Medii , M. Kneussel , A.
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Barberis* , Italian Institute of Technology, Italy, University Medical Center Hamburg, Germany,
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University of Pittsburgh, USA, Tufts University, USA
10:00-10:30 Refreshments | Room: Cavalier Foyer
10:30-12:30 Oral Session 5: Anesthetics, neurosteroids and ethanol: common mechanisms, common targets?
Session Chair :
10:30-11:00 [INV13]
TBC
11:00-11:30 [INV14]
B. Orser, University of Toronto, Canada
11:30-12:00 [INV15] α5-containing GABAA receptors in dentate gyrus as mediators of cognitive flexibility
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E. Engin* , E.D. Zarnowska , D. Benke , M. Sigal , R. Keist , A. Zeller , R.A. Pearce , U.
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Rudolph , Harvard Medical School, USA, University of Wisconsin, USA, University of Zurich,
Switzerland
12:00-12:15 [ST09] Neuroactive steroids mediate an increase in the efficacy of tonic inhibition via an increase in
trafficking of extrasynaptic GABAA Receptors
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A. Modgil* , M.A. Ackley , J.J. Doherty , G. Martinez-Botella , F.G. Salituro , P.A. Davies , S.J.
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Moss , Tufts University School of Medicine, USA, Sage Therapeutics, Inc., USA
12:15-12:30 [ST10] Clarithromycin: a novel GABAAR antagonist and therapy for hypersomnia
A.A. Freeman, L.M. Trotti, P. Saini, J. Carlson, L. Bannister, D.L. Bliwise, M.J. Owens, P.S. Garcîa, D.B.
Rye, A. Jenkins*, Emory University School of Medicine, USA
12:30-13:30 Lunch & Poster Viewing | Room: Cavalier Foyer
13:30-15:30 Oral Session 6: Interneurons: coordinators of neuronal synchrony
Session Chair :
13:30-14:00 [INV16] How inhibition shapes interictal dynamics in awake epileptic mice
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S.F. Muldoon , V. Villette , T. Tressard , A. Malvache , R. Cossart* , Institut National de la
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Santé et de la Recherche Médicale, France, Aix-Marseille Université, France
14:00-14:30 [INV17] Gamma oscillations and the tonically active GABAA receptors of parvalbumin interneurons
I. Mody, The David Geffen School of Medicine at UCLA, USA
14:30-15:00 [INV18]
A. Losonczy, Columbia University, USA
15:00-15:15 [ST11] Hippocampal CA2 interneurones, distinct morphological features and synaptic interactions
A. Mercer, UCL School of Pharmacy, UK
15:15-15:30 [ST12] Activity of identified presubiculum neurons in relation to head-direction and theta
oscillations in freely moving rats
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J.J. Tukker* , Q. Tang , A. Burgalossi , M. Brecht , BCCN Berlin, Humboldt University, Germany,
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Charité University Medicine, Germany, CIN, Germany
15:30-16:30 Refreshments & Poster Session | Room: Cavalier Foyer
16:30-18:00 Oral Session 7: Parvalbumin(+) interneuropathies in neurological and psychiatric disorders
Session Chair :
16:30-17:00 [INV19] Homeostatic control of depressive and antidepressive brain states
B. Luscher, Penn State University, USA
17:00-17:30 [INV20] Restoring brain functions in alzheimer models by enhancing inhibitory interneuron function
J. Palop, University of California, USA
th
24 Neuropharmacology Conference 2014| Oral Program
17:30-18:00
18:00 -18:15
18:15-18:30
18:30 -19:15
19:15
[INV21] Shifting inhibition in acquired focal epilepsy
M.C. Walker*, I. Pavlov, UCL Institute of Neurology, UK
[ST13] Neuregulin-1 overexpression causes NMDA-receptor hypofunction in PV+ and CCK+
interneurons and reduces NMDAR-driven recurrent inhibition
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D. Kotzadimitriou* , W. Nissen , K. Newton , P. Harisson , O. Paulsen , K. Lamsa , University of
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Oxford, UK, University of Cambridge, UK
[ST14] Muscarinic overexcitation of parvalbumin-positive interneurons contributes to the induction
of pilocarpine-induced seizures
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F. Yi , E. DeCAn , K. Stoll , E. Marceau , K. Deisseroth , J.J. Lawrence* , The University of Montana,
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USA, Stanford University, USA
[KEY02] Development and maturation of a hippocampal feedforward inhibitory pathway
C. McBain, National Institute of Health, USA
Close of Day 2