1. family and parenting
2. children

vJ
FEBRUARY, 1962
IN THIS ISSUE
Carcinoma of the Cervix
Activation Analysis
The Class of 1941
Editorial Staff
W. ALBERT SULLIVAN, JR.,
M.D.
Editor
EIVI,'\D HOFF, JR.
Managing Editor
ELLEN
Y.
SIEGELMAN
Copy Editor
Board of Editors
GERARD W. FRAWLEY
WESLEY W. SPINK,
LEE WATTE,'\BEHG,
M.D.
M.D.
Administrative Sponsors
University of Minnesota Hospitals
RAY ~1. A:-'lBEHG,
Director
I
~
Minnesota Medical Foundation
ARNOLD LAZAROW, M.D.,
President
Vice-President
N. L. GAULT, JR., M.D., Secretary-Treasurer
EIYIND HOFF, JR., Exccutit:e Director
COHHlN H. HODGSON, M.D.,
University of Minnesota Medical School
President
University of Minnesota
ROBEHT B. HOWARD, M.D., Dean
College of Medical Sciences
O. 1!EHEDITH \VILSON,
N.
L. GAULT, JR., M.D.
H. MEAD CAVEHT, ~I.D.
\VILLIAM FLEESON, M.D.
RICHARD M. ~!AGRAW, M.D.
Assistant Deans
Minnesota Medical Alumni Association
J.
President
Vice-President
JAMES C. l\!ANKEY, \LD., Vice-President
ROBEHT H. MONAHAK, M.D., Secret{[1'!J
DUANE C. OLSON, M.D., Treasurer
CHARLES
;\IEIL
1\1.
BECK, M.D.,
PALM, M.D.,
I
t
UNIVERSITY OF MINNESOTA
Medical Bulletin
OlJicial Publicatian at
UNIVERSITY OF MINNESOTA HOSPITALS
MINNESOTA MEDICAL FOUNDATION
MINNESOTA MEDICAL ALUMNI ASSOCIATION
Circl/latio1l this issl/e:
vOLU~IE XXXIIl
.'],2()()
Fehrllary 1962
NU\IBER .5
CONTENTS
STAFF MEETING ImpORTS
The Reslllts of Irradiatioll Therapy
of Carcinoll/a of the Cervix
L. J\!.-\KOWSKI, M.D.,
L. McKELVEY, M.D., c.J\1., G. W.
EDG.\H
JOliN
i\:.
FLIGHT, M.D.
\VILHELM STENSTHOl\l, Ph.D., .\ND
Do:'i:'i
G.
MOSSER, J\1.D.
198
Activation Analysis: A Nne Stahle Isotope
ZHethod for Tracer Stlldies
TAMES
T.
Low~L\l\, 1'v1.D., .\l\D
\VILLL\l\I KRIVIT,
~1.D., Ph.D.
203
ALU~INI
SURVEY
The Class of 1941
214
.\W'NESOTA MEDICAL FOUNDATION
227
.\!EDll:AL SCHOOL NEWS
23.'5
Puhlish('d monthly from Octoher to J1111l' at rvlilllwapolis. Minn. Editorial officl's:
1.342 !\ofayo \1(,lllorial, University of \lillIlt'sota. ~linnt'apolis 14. :\Iinnesota.
Second Class Postage- paid at !\limll'apoUs, \Iinlll>sota.
Staff Meeting Report
'The Results of Irradiation Therapy
of Carcinoma of the Cervix" t
Edgar L. ~Iakowsh M.D.,t John L. Mc:Kelvey, M.D., CJvl.,§
C. W. Flight, M.D."r K. Wilhelm Stenstrom, Ph.D.,""
anel Donn G. Mosser, M.D.tt
Vilis I eport deals with the res nIts of irradiation therap\
for carcinoma of the c:ervix administered at the Universih' of
~Iinnesota Hospitals from January 19:39 to Januar~' 19.56. \Vith
on h a fe\\' exc:eptions, the patients here received their priman'
1J'f':ltment at the Universit~, of Minnesota Hospitals.
~IETH()D A~D I\hTEHlAL
All patients admitted to the Department of Obstetrics and
C\'necologY for priman' treatment of carcinoma of the cervix are included in this
report. The classification of tnmor used is
that of the League of Nations Health Organization as published in 1938. 1 The patients are treated while in the hospital with
long focal distance therapy b~· either x-ra\'s
or Cohalt-60 gamma rays first during a period of approximatelY 28 da~'s. Treatments
are given dail\' except Sunday.
The 220 kv. x-ray machine, half vallie
layer 1.8 mm. coppe;', was used from JanlIary 19:39 to Jline 1942. As of Jline HJ42
Fn<:,-\H I .. :\f.\KOWSKI
the' 400 kv. I~ac:hine, half value' layer .'3.9
111111. copper, was employed. Sinc:e April 19.5.'3, for purrloses of
comparative stlldy, alternate patients in each League of Nations
(fThis report was IHl'spntt'd at tlw StnH .\kt'ting of til(' Univcrsitv of Mil1lw,;ota Hospitals 011 January 12, 1Bo2.
tTlw follow-up of path-Ilts was partially support{'d from HJ45 to I Wj4 hy til('
\fillllt'sota Di\'isioll. Aml'dean Callt't'r Sodetv. and hv tlw Sahra ~f. Hamilton
Foundation.
.
.
*:\ssistllnt Proft.ssor. D"l),utnH'llt of Ohstdrics and Cyn{'cology. Unh'prsity of
~Iillnl'sota
~Proft'ss()r
and IIt'ad, Dq);HtllH'llt of Ohstt'tric" and CylH'colog."'.
privatt· practice, St. Johns, .:"\('wfoundl,tncl, Canada. Dr. FIi~ht was a r('
s('arch assistant in ohstt'tric.'i and Gynt-'cology from 1 ~)'~7 to 19.58.
~ III
o 0Profcssol' Emeritus, Division of Radiation Therapy
and Head, Division of Radiation Therapy
tt Proft'ssor
198
THE :MEDICAL BULLETIN
Stage have been treated by the 40() kv. machine or by the radioactive Cobalt unit.
Typically, five fields are used to deliver 3,()OO tissue roentgens diffuselv to the mid-pelvis, including the tumor, during
the period of approximately 28 days. One anterior, two posterior
oblillue, and two hlteral fields are used. The anterior field measmes 18 bv 20 em., each posterior oblique field measures 14 b~
18 cm., and each lateral field mcasmes 12 bv 18 em. One field
is treated each day, delivering :300 to 3,'jO j'oentgens in air to
each portal. Ultimatel~· the dosage has been increased to 3,,'jOO
tissue roentgens for those patients with Stage III lesions or with
occasional Stage IV tumors. Ionization chambers were inserted
into suitable tumors in some cases to determine the aecuracv of
the dosage. The tumor dosage has remained rather eonstan't.
Fig. 1. Radium distributiou
On the da,' of the last external irradiation treatment, radium
is inserted into the uterus and cervix and the upper vagina. A
two-portal platinum tandem measming .5-6 em. is inserted into
the uterine cavity and cervix. This container is loaded with two
10 milligram c01itainers of radium, In addition, a Kaplan colpostat is placed into the vagina in such fashion that each wing of
the colpostat sits in the lateral fornix. Under usual anatomic
199
THE MEDICAL BULLETIN
conditions a central cork is placed between the wings of the
colpostat in apposition to the cervix. Each of these three contains 10 mg. radinm. Thus, a total of ,50 mg. radium is applied
and left in place for 100 hours, giving a total of ,5000 milligram
hours. This application will deliver 1.5,000 to 2,5,000 gamma
roentgens to the cervical tumor.~ The bladder and rectum arl'
packed awa~' from the radium with gauze, and the patient
remains at bedrest during radium therapv.
From January 19:39 to JanUalT 19.56, 1,202 patients were
admitted for primar~' treatment of carcinoma of the cervix. Of
this number, 1,178 patients were given primary irradiation
therap~' and only nine had primary surgical therap\'. Twentvone patients who had irradiation plus surgical treatment were
also inclucled. Fifteen had no therap~' because of the extent of
the tnmor or other severe complications; these untreated patients
were also included in the results of therap". In each case tlH'
diagnosis of carcinoma of the cervix was made on material obtained by biopsy. No questionable carcinoma was included. The
patients were followed to death or to January 1961. Onl~' on('
patient was lost to follow-up and she was considered to have
died from tumor. No attempt was made to separate patients
with preinvasive carcinoma from those with invasive lesions.
RESULTS
The absolute .5, 10, 1.5, and 20 veal' survival rates for the
o\'('r-all gronp and for all stages are ~hown in Table 1.
TABLE 1
ABSOl.UTE SUII\'lV.\!. RATE OF PATIENTS GIVEN IIIHAIOJ.\T10N
THEIIAPY FOB CAIICINOl>IA OF THE CERVIX
Stages
Number of
Patients
,------Absoluk Smvival Rates----,
.5 year
10 year
1.5 year
20 year
('j)
('/)
(,;)
(%)
-- ..
-----
1
11
III
IV
Over-all
422
426
2H6
.59
1,19,3
-
----
Hl.:3
60.1
:3.5.0
:3.4
.5H.H
_
.. _ - - - -
_._----_
------
66.H
.50.0
28.4
2.6
47..5
..
_~
G1.0
62..5
,10.5
8{).8
21.:3
4.:3
,3H.8
2.5.7
16.7
,39.2
----
-_.-
- - -- - -
Two hundred fort~,-three patients were treated with the
220 kv. machine, 818 patients with the 400 kv. machine, and
114 patients with radioactive cobalt; .3 patients received radium
onl\', and 1.5 patients had no therapv.
200
THE MEDICAL BULLETIN
Fiftv-sevcn (,'57) patients, or 4.8 pCI' cent, had carcinoma of
thc cervical stump, and .35 patients, or 2.9 per cent, had adenocarcinoma of the cervix. Those patients with carcinoma of the
cervical stump maintained essentiall~' the same survival rates
as the over-all group, except for a slight decrease in Stage I,
Patients with adenocarcinoma of the cervix, however, had
worse prognoses when their lesions had advanced be~'ond Stage
1. In addition, 63 patients, or 5,2 per cent of the total group,
had carcinoma of the ccrvix associated with pregnanc~'. These
patients showed essentially thc same absolute five-veal' smvival
rates as did the over-all group, except for Stage II. Only seven
of these had Stage II lesions and the absolute five-year survival
rate was 43 per cent in the patients who were pregnant.
Fistulae developed in 17 patients, for an incidence of 1.4
per cent, Aseptic necrosis of the femoral head and neck developed in 13 patients, or 1.1 pCI' ccnt. Seven patients or 0.6 pCI'
cent, died during or immediately after irradiation therapy.
During follow-up, a second primary tumor developed in each
of .'5.'5 patients (incidence of 4.7 per cent). Adenocarcinoma of
the breast was a most common type, with less frequent adenocarcinoma of the colon. Among those with recurrent or persistent
carcinoma of the cervix, ,58 patients were each given another
course of irradiation therapy. Only five of these, (8.6 per cent),
were alive and free of tumor after five years. Radical smgical
treatment was performed in 29 patients with recurrent or persistent tumor of the cervix. Thirteen of these, (44.8 per cent),
were alive and free of tumor after five veal's.
DISCLJSSIOI\
Prior to this stud~', patients at this hospital treated for carcinoma of the cervix received about half the x-raY dosage and
two-thirds the radium dosage given to patients in this studv.
The standardization and Widespread application of the newer
method, using larger doses with continuous irradiatiou, has produced a significantly greater smvival rate, while offering the
advantages of relative safety and simplicitv. The results obtaincd
in this and other studies dearly iudicate the effectiveness of
accmately applied irradiation therap~' in carcinoma of the cervix.
Not one case of leukemia was observed to develop after
the irradiation therapy, Second primary tumors, possibl~' induced by irradiation, developed in two patients; one of these
lesions was an osteogenic sarcoma and the other a generalized
I:'mphosarcoma.
For the persistent or recurrent tumor, re-irradiation has vel' v
little to offer provided the patient has received adequate pri201
THE MEDICAL BULLETIN
mar~' therap~'.
In such cases, radical surgical treatment has bpen
more effective.
REFERENCES
1. Heyman, J.: Atlas, Leagu(' of Nations Health Organization, Stoekholm, Sweden, 19·'38.
2. Stenstrom, K. \V.: '\[all11a! of Radiation ThewllY, Springfield, Ill.,
Charles Thomas, 19.57, p. :3.5.
202
Staff Meeting Report
Activatioll Analysis: A New Stable Isotope
Method for Tracer Studies Of
Taml's T. Lowman, ,Iv!.]).!
William Krivit, M.D., Ph.D.§
.Ai
etabolism of the bodv constitnents in health and disease
has been extensivelv studied bv nse of radioactive tracer techniques. In particula;', the basis for Olll" more complete knowledge
eonceruing physiology of erythropoiesis has been provided by
radioactive elements such as Fe-.59, Cr-:)] , and Co-GO. Yet the
bare beginning made in the study of absorption, transportation,
and assimilation of iron in newbol'lls and infants has been severely hampered by the irradiation hazard. This
problem has canscd the present investigators to scarch for cqually informativc nonradioactive tracer techniques.
Activation analysis appeared to hc a thcoretical possibility. ThcreFore, the development and standardization of a tracer method
using activation analysis of iron-,58 (Fe-.58)
was initiated. This report is a preliminary
presentation of the theory, methods, and
rcsults of activation analvsis as a method
for plasma iron clearanee~.
Activation analysis, simply described, is
T. LOWl\fAN
the production of a radioactive isotope frOln
a nonradioactive, stable isotope by neutron bombardment.
As far back as 1938, activation analvsis had been used for
determining the <l'wntities of trace eleme'nts in ores and metals.!
The data indicated that trace elements could be detected in
JA~lES
°This H-'port was PH's{'lltl>d at tilt' StaR' r..lcl'ting of til(' Unin'l"sity Hospitals OIl
Dect:'1ll1wf 8, I Dol.
tThis work \"'as supporh·d ill part hy Crallt No, 11-:3107 (eLi) from tIll' National H'_'i.ut Instituh' and was carried out during the tenuIT of it Postdoctoral
Fellowship frOI1l the National Heart Institute, Unitt'd Stith's Public lIea1th Service ht'}d hy J .L. The study was Illadt· possihle hy tIlt' cooperatioll of tlw ~kdical
Departl11(,l1t, BrookhH\Tll National Lahoratory.
:r.:\Ipdical Fellow Specialist, DepartllH'llt of Pediatrics, University of Minllesota:
ReSl'ilrch Collahorator. Brookhaven National Lahoratory, Upton, 'L.1., Nt'w York
§Associate Professor. Departlllent of Pediatrics, University of !\1itllH'sota, MilllH'apolis, J\lillJH'sota, and Hesean.:h Collaborator, B.N .1..., New York.
THE ::\1 E DIe ALB U L LET I :-..-
concentrations of parts per billion. It was not until 1956 that
sodium, potassium, phosphorus, and manganesc were measured
in micro-samples of human serum and muscle by several investigators. ~-l;
Therapeutic utilization of this method has also been attempted. FaIT and assodates' injected boron-IO and showed that it
was concentrated in gliomas. They then exposed the patient's
head to a beam of thermal neutrons; the boron became activE',
emitting very short half-life particles which were also of very
low energ~'. Thus only the tissue immediately adjacent to the
captured isotope received a cytopathic dose of irradiation.
In a recent review of this general field, Ogborn and associates' dealt primaril~· with the reactors available but also discussed manv possible uses for this method. To the present investigators' knowledge, howlever, this technique has never before
been applied to tracer studies made ;11 U;VO.
THEORETICAL REQUlHE:\IE:"TS
Fan
ACTIVATlOl" A:"ALYSIS
The three relluirements of an isotope for activation and
lluantification are as follows:
1) The isotope must be activatled in dircct proportion to its
concentration in a sample; and an~· subslelluent sample exposed
to the same beam of reactor neutrons for an identical period of
time must become activated to the same extent. These requirements have been met in mam' different s\'stems and with the
lise of different isotopesY·!"
.
2) The isotope must be activattcd to a significant yield within a reasonable time. This Yield can be calculated from the
following equation:
.
At = Nf(J' (1_e-· 69 :3t/TJf)
At = disintegrations second for a given time (t) of activation.
N = the total number of nuclei of the ellement present in
the sample.
f = the slow neutron flux of the reactor (the numbcr of
thermal neutrons present/ em~ sec).
(J' = the atomic cross section (the probability for activation
of a given isotope; a compilation of isotopic cross sections can
be found in any recent handbook of physics).
T)~ = the half-life of the radioisotope produced.
According to this equation, in order to increase the disintegrations per second one may either (a) increase the amount
of material activated, (b) increase the total length of activation
20-4
THE ).lEDICAL BULLETI"
time, or (C) use a higher flux reactor. The latter is the most
advantageous, since the slow neutron flux of most reactors is
from 1 X 1011 to 1 X lOB neutrons cm~/sec. An increase in
this factor in the equation will provide a directly proportional
increase in the final yield. The limiting properties of the isotope
are its neutron capture cross section and the half-life of the
isotope produced-the combination of large cross-section and
short half-life being the most advantageous.
3) Finally, activation analysis requires that an easily detectable disintegration be produced by the activated isotope. In
order to be quantitated accurately the isotope either should be
chemically separated from the sample and counted or should be
separated from other compounds by the use of specific detectors
and pulse height analyzers.
The latter statement perhaps requires a brief review of the
detection of isotopes: Isotopes generally fall into four classes,
alpha, beta, and gamma rav emitters, and mixtures of these.
3500
3000
2500
(J)
fZ
2000
::::>
8 1500
1000
500
CHANNELS
20
40
60
80
100
120
59
137
SAMPLE OF Fe t- C5
140
Fig. I
Spectrum of a mixed sample of Fe-,S9 and Cs-137 plotted with
counts as the ordinate and the arbitrary channels from a multichannel analyzer as the abscissa. This ~lemonstrates the separation of isotopes by gamma-ray spectroscopy.
20,S
THE
~I
E DIe ALB U L LET I :x
The first two types of emission are generally of little help in
separating isotopes since no existing detector will accurately and
simply separate their energy characteristics. Gamma ra~'s, on the
other hand have been of exceptional value following the introduction of the crystal detector which is activated bv sodium
iodide thallium. This detector receives the emitted particles and
is capable of differentiating the energy and the number of disintegrations of each energ~" \Vith a multi-channel anal~lzer the
energies from 0 to 2 million electron volts (Mev.) or an~' desired
energy range can be partitioned into 100, 200, or 400 channels.
and the disintegrations are sorted and counted for each channel.
A spectrum of energies can be plotted with counts per unit time
as the ordinate and the arbitrarv channels as the abscissa. The
peaks are very characteristic for' each isotope and should fall at
the same channel (i.e., energ~' level) each time. From the spectrum of a mixed sample of Fe-59 and Cs-137 (Fig. 1), it is
clearl~' evident that these two isotopes can be separated using
the available equipment.
The channel numbers of different energy peaks are linear
within 1 per cent over the entire upper 90 per cent of the scale.
\Vith two standard known peaks a simple formula will convert
the channel number of an unknown peak to its energy in million
electron volts.
Complications can occur when the isotopes used have ver~'
similar energy peaks. However, there are many modifications of
the gamma ray spectrometer l l which allow quantification of
these isotopes. Dr. D. C. Borg and co-workersl~ have reported
a very elegant system using both gamma and beta emissions
to separate contaminating isotopes in irradiated human serum.
\Vhen the energy of an unknown peak is established, counting the sample to calculate the rate of disappearance or half-life,
which is another characteristic property of a given radioisotope,
will in most cases permit positive identification of the isotope.
THEORETIC-\L REQUIRE:\!E:'\TS FOR THE USE OF IRO:'\-S8
As.-\
TRACER
The plan was to obtain plasma iron clearance values similar
to those obtained by Huff13 and others who injected radioactive
iron and followed its disappearance from the serum. The various
stable isotopes of iron were reviewed, iron-58 presenting an ideal
isotope for activation. Its atomic cross section is 0.98 Barns, and
on thermal neutron bombardment it becomes the gamma emitter
Fe-59. This reaction is conventionall~· written Fe-S8 (n-y) Fe59. Fe-59 has two characteristic peaks one at 1.1 !\Iev. and
another at 1.3 ~Iev. These peaks are in the moderatel~' high
206
THE
~[E[)ICAL
BULLETIN
energy range. On reviewing the other elements in human serum
which might be activated, we noted that ouly sodium and potasshull seemed likdy to coutribute peaks iu this region. Fortunatelv, both Na-24 and K-42 each have half-lives of 15 hours or less.
Siuce Fe-,59 has a half-life of 45 days, by delaying counting for
a few days after irradiation, one notes that those interfering
peaks disappear, leaving only the Fe-,59 peaks.
To be a true tracer, an dement or compound must be utilized in pathways and chemical combinations that are identical
with those of the naturally occurring clement. The element
either must be non-naturallv occurring or must occur in such
small consistent quantities that additions too slmtll to alter the
homeostatic state arc readilv dctectable.
Fe-58 consistently appe;lrs as only 0.3 per cent of naturally
occurring iron. The normal serum iron of 100 micrograms per
100 ml. contains ..'3 micrograms 100 cc. or .003 micrograms/cc.
Thus naturally occurring Fe-,58 contributes 6 per cent of the
total Fe-.'58 in an enriched sample containing .0,5 micrograms (cc.
This activity is compensated for by irradiating an unenriched
sample, i.e., preinjection serum.
Fe-,58 in a concentration of .0,5 microgram cc. is considered
a true tracer, since this amount represents a small fraction of the
st'l'um iron.
After calculating the expected disintegrations per second, we
observed that 0.0,5 micrograms of Fe-,58 activated for a period of
three weeks iu a reactor with a neutron flux of 101~ cm~/sec
would yield approximatelv two hundred disintegrations per second. Considering the efficiency of counting equipment and the
necessity of counting only the specific peaks, calculation led us
to expect 150 to 200 net counts per minute in each sample.
Fe-,58 was obtained as ,50 per cent elll'iched Fe/'''O:l from
Oak Ridge National Laboratory. Conversion to injectable ferrous
citrate was performed by Abbott Laboratories.
In order to standardize this method as a tool for tracer studies, the follOWing procedures were carried out:
1. Til vitro demonstration of Fe-58 converted to Fe-,59 in
serum.
2. Til vitro quantification of standard dilutions in normal
human serum .
.'3. Simultaneous clearance studies of Fe-,58 and Fe-.59 ill
vivo plasma iron.
4. Til vico Fe-58 plasma iron clearance studies to establish
norms.
207
THE 1\1 ED I
r: A L
Il U L LET I N
'400f
1200
B N.L # 16
(j)
w
f:J
Z
::2'
0
100°f
800,...
~
"-
(j)
f-
z
600
:J
0
u
1\00
200·
20
40
60
80
100
140
160
180
200
CHANNELS
Fig. 2
NOrJnal human serum sample count<'d 14 clays after eompldion
of 21 days' adivation. Notice there is no Fe-,"iD peak at Chaunel
WH. TIll' peak at Channel 144 is most prohahlv Zn-o,"i,
First, normal human serum was enricl1l'd ill vitro with .0:)
micrograms Fe-,S8. This enriched serum, plus normal tlIlt'nriclll'(]
serum, and an aqueous solution of Fe-,S8 were subjected to lll'Utron homhardment for three weeks. Figme 2 reveals the count
for the normal serum sample (not enriched with Fe-.58) 14 days
after it was removed from thc reactor. Figure :3 is the spectrum
of thc Fe-.S8 enriched serum counted at that time. The peak at
channel 144 has a half-life consistent with that of Zn-6,S amI is
also the correct energy for that isotope. This is somewhat unfortunate, since it completely obscmes the low (1.1 Mev.) energ~'
peak of Fe-.S9. The peak at channel 168, however, corresponds
exactly with the 1.29 Mev. peak of an Fe-,59 standard and on
time cmves demonstrates a half-life compatible with that of
Fe-,S~). This peak is Fe-.S9 uncontaminated bv other elements.
Second, dilutions of Fe-,S8 were added t(i a standard htlln~lI1
control serum. Fe-,S8 concentrations were 0.1, O.O,S, 0.02.5 and
0.0 I,5 micrograms cc. This procedure was performed in quadruplicate. Although some of thest' recoveries were encouraging,
dilution errors and loss of sample ideutifkation thwarted the~e
attempts at accurate (luantification.
208
TIlE 1\1 E D rCA L
II U L LET 1 N
1400
BN L # 17
1200
V1
~ 1000
::J
Z
o~ 800
.....
z~ 600
::J
o
U
400
200
l..-.L-.1__ L-l__ L-l.-~
20
40
60
80
J_J .__
100
L_~----.L.---"--I ---'-_.L--'----'-_L~=
120
140
160
180
200
CHANNELS
Fig. :1
Irradiated Serllll1 ill wldeh there is .0.) IIlil'rograllls/ee. Fe-5H.
Notiec thc clearly visible peak at Channel WH. This is Fe-.51)
prodllccd hom the Fe-.5H.
Third, Ft'-.'59 and Fe-,'58 were injected simultaneouslv into
four adult volunteers (Fig. 4). The average Fe-.'59 TJ2 was 100
min. (H.A.-117 min., L.L.-107 min., 0.5.-98 min., D.K.-7H
min.) The two Fe-58 plasma clearance curves that could hc
plotted revealed a relativc1~' close agreement (L.L.-9G min.,
0.5.-10.'5 min.) with the Fe-.'59 clearance values.
Fourth, Fe-.'58 was used alone as an ill vivo tracer. Five
voung adult volunteers each received a dose of Fe-.'58 calculated
to add .'5 micrograms 100 m1. to the serum. At appropriate illtl'rvals, samples were drawII to dcmonstratc thc disappearallee
rate of the iron tracer. These samples were irradiated for three
weeks and then were allowed to decay 10 days before counting.
Figure .'5 represents the counts (plotted on semi-log paper) determined to be contributed by the Fe-.'59 produccd from thc
injected Fe-.'58. The actual counts were expressed as thc numbcr
of counts obtained in the channels covered bv thc 1.29 Mev.
peak of Fe-.59 per gram of dried serum per U1{it of time. Thesc
counts were corrected both for room background and for the few
counts in a prc-injection serum. These pre-injection counts may
20\)
T II E 1\1 E DIe ALB U L LET I N
have been contributed by the 0,,3 per cent naturally occurring
Fe-,S8, It was possible to plot four of the five plasma iron disappearance curves; however, the average T'" of 68 min, is somewhat shorter than that reported using Fe-,s9.
I,OOO,ODO
800,000
FeS8 Plasma Clearance (OS)
=e58;~2°
500,DOQ
les
~ Fd'Sf)lasma Ciearar,cc (L L)
Fe 58 ~ 1/:: 96 r\1'n
~
",'In
Fe S9 T '/2::: 93\-1In
4QU,000
200,0")0
z
2
o
IOU,<VJO
~-
-
8U,000
~
4U,000
~
2
(')
"-
VJ
f-
U
20,C'(X
I
0l ~
1:1 UUU
,
1_.1._ 1
30
50
1
I
')0
_L_ L_--.1.-L-----.l
120
150
L------L-J
180
l __ L_.l...-J_
30
50
1
90
.L__ L __.1_ L
120
.1_L-L_.l
150
180
MINUTES POST iNJECTION
500,000
Fe58 Plasma Clearance (H A)
58
400,000
Fe
T~2
c__ e 59 T I
2
0
Fe
S8
Plasma Clearance(DK)
Fe S8 r 1/2
Cou Id not be
plot fed
0
Cou Id not be plotted
Fe'-;9 T'/2::: -;8 Mm
::: II~'
Z200,OO() !
~i'5 100'000~'
t
80,000
"-
u)
f-
U
•
60"JOO
40,000
~
!
I
2'J,000 :1
10,000
--L-='c--L--"----"----"----"---"--l!_J!~L_J____'____' L_~__L~!
I
LI
o
30
60
90
120
150
180
30
60
90
120
150
180
MINUTES POST INJECTION
Fig, 4
Plasma Iron-58 clearanc'" studies of four normal adults, Note
the close agreement in O,S, and L.L. of the Fe-58 and Fe-59
plasllla clearance,
2lO
I
!
THE
MEDICAL BULLETIN
Fe
5
•
PL.ASMA CLEARANCE
MINUTES POST INJECTION
Fig. .5
Fc-.5R clearance in five normal adults, ddnlllincd bv activation
~
analysis.
DISCUSSIOX
The goal of utilizing activation analysis of Fe-.5S as a nonradioactive tracer for ill dvo human studv has been met. The
capability of distinguishing the serum Fe-.5·S converted to Fe-.59,
the quantitative standardization of Fe-.5S in serum and the
Fe-.5S plasma clearance fall-off have been presented.
Several problems remain to be answered before this method
can be considered a workable tool of the clinical investigator. In
reviewing the plasma iroJl clearaJlces in Figures 4 and ,5, one
may note an inconsistency in the several points that are widely
dispersed. Two explanations can be offered: 1) Identification of
the samples must be improved since the heat generated in the
reactor has occasionally destroyed the ink previously used for
marking. This defect has been corrected recently by use of
heavier aluminum foil containers on which the numbers are imprinted into the metal. 2) The second explanation for the erratic
results may lie in the degree of hemolysis present in the serum
samples. Irradiated red cells demonstrate a high peak of Co-50
at 1.33 Mev. If these completely incongruous samples were
hemolyzed, one would expect to observe the very long half-life
of Co-50 (,5.27 veal's) rather than the 4.5 davs of Fe-.59. At
present the T)~ (if one of these peaks appears' to be 70 days.
this does not necessarily preclude its being Co-50, however, for
it is a mixed peak, combining Fe-,59 and Co-50, and will demonstrate a half-life much nearer that of the shorter half-lived
Fe-,59 than of the Co-50. Several months will be required for
211
THE :\TEllICAL BULLETIN
the iron-,59 to disappear, leaving a pure Co-oO peak to be identified. When the specific energy of this mixed peak is compared
to those of Co-oO and Fe-58 standards it is the same as the
co-oo. It seems likely that Co-oO from hemolvzed red cells will
interfere with the de'termination of the Fe-,58' content of serum.
\Vhen Iwrfected, this method will offer several advantages.
rt will allow investigators to study iron metabolism in children
withont snhjecting them to the use of radioisotopes. Furthermon>, the nse of these non-radioactive isotopes does not entail
any loss of activitv during a prolonged study. Thus a pregnant
woman could be given an injection of Fe-,58, and months later
the red cdl content of Fe-58 in the newborn could be determined to answer some of the '1uestions ahout iron mctabolism
d lI1'ing pregnancy.
:-'1any dements lend themselves to slmlv by this method.
We hav~' demonstrated Ca-47 and Cr-,51 birth 'produced from
nonradioactive tracers in human serum. The identification of
Zn-o,') in human serum is interesting. This element could easily
he '1uantitated with great accuracy: As little as (l.07 micromicrograms of this element can be easil~' dctected and mc'aslll'ed
wilh accuracy.!1
Sl1\f1\L\TIY
The background amI technical reljuirements for activation
analysis of isotopes have been descrilwcl. A new use of this
method of analysis for tracer studies was outlined. Using Fe-58
as an example, thc authors pointed out some of the interesting
discoveries and problems c'ncountered in standardizing a tracn
study using Fe-,58. The possihk application to ollll'r areas was
also discussed hric'flY.
AdolOlr/('t/gHl('lll: TIU' allthors wish to ('xpress their silH.'{,rt, gratitlHh' for tll('
assistalll't' gi\'('11 hy Dr. D. C. Borg, Bl'ookhan'}) Niltiollal Lahoratorh's. and for
tht· US(' of the main n~a('t()r then', \\'l' also whh to thank the lllany other people
who h~ln_' eontributt-'d to this study.
REFEHENC:ES
I, Sc'ahorg, C. 'I'. and Livingood, J. J.: Artificial HadioaC'tivity as a
T"st for \(innt<' Trat"'s of m,'nH'nts, I. AIll. Cht'lll. Sot'. f10: 171->4,
198K.
'
;:>"
H"iffl'l, L. and Stont', C. A.: N,'ntron Activation Analysis of Tissnt': t\(I'asnJ'('nH'nts of Sodilllll, Potassiulll, aud PIllisphorns in
\(IISt'I<', J. Lah. & Clin, \(t'd. 49:2Kf1, H),57.
:1,
\\'illiallls. I. I).; Aus('ll, H. ~I.; R{'iH"('l, L.; Ston{', C. A.; and Karl,
H, \1.: EI~'drolyt" L"wls ill Normal aIII I Dystrophic },(lIscle De-
termillcd bv Ncutron Adi\atioll, Lancet Vo!. 1:4(H, 1857.
212
TIlE 1\IEDICAL BULLETIN
r.:
4. Koch, 1I. J., .I r.; Smith, E. R.; Shimp, N. F.; and Connor,
Analvsis of Trace Elenwnts in II nman Tissues: I. Normal TisSllt·s,· Cancer 9 :4~)9, 19,56,
S, Sp('ucer, R, 1',; l\!itclwll, T. G,; and King, E, R,: Neutrou Activatiou of Sodium in Blood Serum, J. Lab. & Clin. l\Ied, ,')0: 64(i,
1~7.
.
n. Borg, D. C.: Proceedings of the S('coml International Conferel1l'('
on the Peaceful Uses of Atomic Energy, Gem'va, I D,')H. p/H41,
Vo!. 24: 2H:1, New York, United Nations, ]}),')D.
7. Farr, L. K; Sweet, \Y. II,; Robertson, I. S.; Foster, C. C.; LoeksI(·y, II. B.; Sutherland, D, L.; \!l'm!efsolm, M, L.; and Stickley,
E. E.: N('ntron Captnn' Therapy with Boron in the TreatnH'nt of
C!ioblastoma i\[ ultiforllH', Am . .J. Roentg(']]o!. 71 :27D, W,,)4.
H. Ogborn, R. K; Dunn, A, L.; Bloteky, A. .J.; Johnson, G. F,; alHl
James, L. R.: N('lltron Adivation Analysis, Aul. J. R()('ntg('no!.
H,5 :976, W(n,
D. Clark, II. \1. alHl Overman, R. T.: Ddermination of Traee
Amounts of Elemellts by Radioactivation Analvsis, United States
Atomic Enngv COIlHuis~ion DocnnH'nt l\!DDc'-1:129, Oak Ridgl\
Tennl·sS(·('.
10, Tohias, C, A, ,md Dmm R, \V.: Analysis of l\licrocolllposition of
Biological Tissut, by Means of Inducl·d Radioactivity. Atomic
ElH·rgy COllllllission DOCIIllH'nt 2099B, (l\lonthly Progress Rt·pOl't
N,D,P. 4HA, Div, 2) ImH', 1947,
11. Crout han leI, C, E.: /\/J/J/iel! GallI/lUi-Hay S/w('/mllwlry (Vo!. 2,
Intemational Sni('s of i\[onographs on Analytical CIH'mistry),
New York, I'<'rgamon Press, 1~)60,
12, Borg, D. c.; Segal, R. K; Kienle, P,; and Campbell, L.: Selective
Radioadivation and \[nltip]'· Coincidt'nce Speetrometry in the
Detennination of TraCI' E],'nH'nts in Biological Material; MeasUH'IlH'nt of l\LmgalH'se, Intemat. J. App!. Radiation & Isotopes
2: 10, wn I.
1:1. IIllfl', R, L.; lIemH'sS\', '1', C,; Austin, It K; Carcia,
F.; Rohnts, B. 1\1.; and Law':(·Ill'('. .I, II.: Plasma and Red Cell'Iron Turnover in Normal Subjeds and in Pati('nts Having Various Hematopoietic Disorders, .I, CIi". Illw·st. 29: 1041, H),50.
r.
213
Ahunni Survey
THE CLASS OF 1941
Ttcenty years after graduation from Medical School, memo
hers of the Class of 1941, Unit)ersity of Minnesota, are tce11 settled in their medical careers. The editors of the M EDlCAL
13 ULLET I N contacted or ohtained information all 92 of the
106 graduates. Six are knotcn to he deceased. The ma;ority
.\·ert)ed ill vVorld '"Val' II, which hurst upon the United States as
they emerged from medical school.
Today more than half (5.3) of those accollnted for are practicing in speciali::.ed fields of medicille. Ahout one-tltird (.31) are
general practitiollers. Set)en are occllpied full time in academic
medicine.
(By com]Jarison, the Class of 1951, sumeyed recently, had
Sl/hstantially //lore [49] in general ]Jractice, and fewer [29] in
specialties).
Forty-one graduates of 1941 were found to he practicing in
Minnesota. Thirteen are practicing in California, and the others
are scattered throllghout the United States.
The careers of most are reaching maturity, and a sense of
professional achievement shines hettceen the lines of their personal reports. Some luwe attained tcorld recognition. Many reported they llOW hat)e time for golf, camping trips, llOhhies, and
family actit)ities. All hut a handful are married, three to other
physicians, and there teas one marriage hettceen classmates.
Those who ansu:ered the sumey reported a total of 240 children.
Their children tend to he of high school and college age. Ttco
graduates are the proud parents of six children each.
Here is informatioll on the 92 tv/w tcere located:
Charles D. Adkins is practicing with a group of three other
physicians in Minneapolis. His home address is 1011.5A Thirt~·­
Sixth AYe. N., where he liyl's with his wife, Eudora, and children, Jonl's, Ii, and Jennifer, 1:3.
\Villiam H. Anderson is an anesthesiologist at Swedish Hospital, Minneapolis. He liyes at 6i09 Southcrest Drive, Minneapolis.
Duane R. Ausman and his wife, the fonner Jeanne Booth.
live at 1.57.') Summit Ave., St. Paul .5, Minn. They have four
children ranging from three to twelve years of age. 'Dr. Ausman
is engaged in solo practice in St, Paul.
214
THE :\[ E DIe ALB U L LET I N
Velemir M. Baich is in private practice alone at Coleraine,
Minn. He has three children of high school age.
J. Gordon Bateman is an orthopedic surgeon practicing in
Long Beach, Calif. The familv includes his wife, the fonner
Olive Lundgren, and five childi·en. Home address is .5808 Corso
di Napoli, Long Beach.
Allan J. Benson is an intemist associated with thc San Jose
Medical Clinic, San Jose, Calif. The familv home is in Co;ote,
Calif. (P.O. Box 288). Mrs. Benson is Hie former Alice Nisswandt. Their four children are John, 10; Jean, 8; Donald, 7;
and Peter, 4.
Manuel R. Binder is a private surgeon in Minneapolis and
an instructor in surgery at the U niversit~· of Minnesota (MilllH'apolis General Hospital). His family includes his wife, Ruth, and
three small children. They live at 1020 Angelo Drive, Minneapolis 22.
Eleanor Botha is a physician at the Stndent Health Service,
University of Denver. In private life she is Mrs. Thomas J.
Kennedy, and is the mother of twin daughters, Kathleen ailll
Maureen, 11, and a son, Mark, 8. The familv home is at 24.55
So. Dahlia Lane, Denver, Colo. Her husbanci is a classmate.
Robert W. Brandes lives at .3817 N. Pinehurst Ct., Peoria,
Ill. He is a partner in the practice of obstetrics and g~!necolog"
and teaches at Methodist Hospital. Dr. Brandes' wife passed
awav in Mav, 1961 from a brain tumor. There are three childreli, Hobert Jr., 14; Melinda, 9; and Hebecca, .5.
Charles F. Brigham is a surgeon in St. Cloud, Minll. (Doctors Park), where he lives with his wife, Margaret, amI two
children. He is a fellow of the American College of Surgeons,
and is certified by the American Board of Surgerv.
Donald I. Bryant is an internist in practice in Highland
Park, Mich. He is 011 the staff of Providence Hospital and
Straith Memorial Hospital in Detroit. The famil~' home is at
181.38 \V. Onter Drive, Dearborn, Mich. His wife is the former
Laura Ellen Quinn. Thev have three children.
Winfred H. Clarke practices orthopedics with a gronp in
Portland, Ore., and is a clinical instmctor in orthopedic surgen'
at the Universit~· of Oregon Medical School. He is president of
the medical staff at Providence Hospital. The family home is at
.388.5 N.E. Wistaria Drive, Portland 12. His wife is the former
Ontey Brohaugh. They have four children ranging in age from
4 to 18 years. "All are well, happ", and healthv."
21,5
THE MEDICAL BULLETIN
. . . . A physician's Lasl FruTltier
Norman C. Carlson is a general practitioner who built and
now operates the Fall River Medical Center in Fall River, Calif.
He lives in what he describes as the "last frontier of good hunting and fishing in California." His new home is on an 80-acre
lot of pine and oak trees at the base of a mountain. The family
lived in Newport Beach, Calif., from 1952 to 1959, then moved
to northern California to a "climate much like Minnesota minus
the below zero temperatures." The family, "all in good health,"
includes Mrs. Carlson (Margarete H. Wahlers); Norman, 18;
Steven, 15; and Jannine, 12. The eldest is a freshman at Oregon
State U.
Frederick C. Closuit has practiced general medicine in Aitkin, Minn., since 1946. He is associated with a classmate, Vel'lle
A. Schulberg, at the Aitkin Clinie. He is married, has two children, and is a member of the American Academy of General
Practice.
David Clough is deceased.
Warren A. Coliton, Jr. is an orthopedic surgeon. He lives at
12016 N. 67th St., Scottsdale, Ariz., and practices with a fivcman group called Orthopedic Associates in Phoenix, Ariz. He
is chief of the orthopedic residency program at the Arizona State
Crippled Children's Hospital. Mrs. Coliton is the former Mary
Morris. Their childJ'en are Susan, 18; Warren A., III, 14; and
Christine, 3 mos. He still plays golf as a hobby, and has a handicap of 2.
21G
THE MEDICAL BULLETIN
George \-V. Collen is a cardiologist ill
Los Angeles, Calif. He is also a clinical
instructor in l'vll'dieinl' at U.C.L.A., and has
a SOli, l\lartin, who is a pre-medical student
there. Jlis othn children arc Hobert, J G,
and Louise, J fl. \Vith his wife, Sara, ~uld
ehildrell, he makes his home at (j:3G2 W.
71)th St., Los Angl'!es 4.'5.
Morris D. Corman is deceased.
Stanley B. Crosbie is an assistant pl'Ufessor of medicine at the Universitv of MinGEOHGE w. COJ.LE:"J
.
Ilesota, assigned to the Medical Sdlool's
teaching program at the Minneapolis Veterans Administration
Hospital. His wife is the former Helen Blair. Thev have a H)'Tar-old danghter named Joan. The falllilv hOille is <)narters
1:35, V.A. Hospital, Minneapolis 17.
Donald T. Cundy is an ophthalmologist practicing alone in
Millneapolis. The familv home at .'5.'522 Edgewater Blvd., Minneapolis 17, includes his wife, lola; Donald T. Jr., I/); identical
twin daughters Joan and Jovee, 14; amI Connie, 10.
LaMeta F. Dahl practices as a Public Health pediatrician in
Denver, Colo., and teaches at the Universil\- of Colorado, Dc·
partment of Pediatrics. Her husband is also a ph~'sician, Dr.
Michael Lubchenco. The~' have six daughters ranging in age
from two to fOlll'teen ~Tars. Home is at 12.50 St. Panl, Denvn.
John G. Davidson is an orthopedie slll'geon in Butte, Mont.
He is in practiee alone, amI lives at 1/):30 Hohlles Ave. wilh Ids
wifc, Mar~' Jane, and two ehildrcn.
Grant R. Dicssncr is an internist at tIll'
Mavo Clinic with a subspecialt.,- in rhelllnatologv. He is also an instructor in the Ma~'o
Foundation, Graduate School, University of
Minnesota. The famih- home at Slu'nlvslopes, Hoehester, Min·n., houses his wife,
the Fonner Margaret Crenshaw, and Cathv,
12; Marc, 11; AlIn, G, amI Nanev, :3.
John G. Fast is a slll'geon practicing
with a gronp in Hiverside, Calif. He is elll'rent president of the Hiverside County
Medical Association amI lives at .')G7.'5 VieGRANT n. DIESSNEll
toria Ave., Riverside. He is married to the
Fonner Margaret Buffington. The'- haye three children.
217
THE MEDICAL BULLETIN
William O. Finkelnburg is in private practice in Winona,
Minn. His familv includes wife Yvonne; Karl, 9; Karen, 7; and
Joanne, 6. Home address is 328 W. Fifth Street, Winona.
Alfred M. Freedman is full time in teaching and research
with the Department of Psvchiatry, New York Medical College,
wlIere he is Professor and Chairman of the Department. The
family lives at 161 W. 86th Street, New York 24, N.Y., and includes his wife, Marcia, and two sons, Paul, 12, and Daniel, 9.
Donald W. Freeman is an obstetrician-g~'necologistwith the
St. Louis Park (Minneapolis) Medical Center, and teaches as a
clinical assistant professor at the Universitv of Minnesota. He
participated in the Minnesota State Maternal Mortalit~, Stud,',
and has published several papers on the subject. His children
are Judith, 18; MmT, 1.5; James, 12; Michael, II; Laurel, 9;
and John, 8. Mrs. Freeman's maiden name was Helen Lambe.
The famil~' home is at .5940 Park Ave., Minneapolis.
David C. Frisch is a dermatologist practicing solo in Portland, Oregon. He is also an instructor at the University of Oregem Medical School. The famil~' home is at 3.5.53 S.W. Jerald
Ct., Portland. Mrs. Frisch is the fonner Irene Chucker. Thev
have two daughters and one son.
.
Dorothea E. Gladitsch lives in Brevard, North Carolina.
Robert A. Green specializes in internal medicine and hematologv as an associate with the St. Louis Park (Minneapolis)
Medical Center. He is a clinical associate professor of medicine
at the Universit~, of Minnesota, and heads a "family of campers
and skiers." Ivlrs. Green is the former Bettv Radlev. Their children are Kathleen, 12; Gail, 11; Laurel, 9'; and Je)hn, 7. Home
is at 4377 \Vooddale Ave., Minneapolis 22.
John K. Grotting is a plastic surgeon in
practice in Minneapolis, and a clinical instructor at the University of Minnesota
Medical School. The famih· home at 6213
South Knoll Drive, Minneai)olis 24, shelters
wife Shirley, and their five children.
JOHN K. GROTTJ:XG
218
Fred J. Hafiz practices general medicine alone at 1290 20th Ave., San Francisco, Calif. His family, consisting of wife
Yvenne, and daughters Yvette, 13, and Yolanda, 12, lives at 1640 Valencia Street,
San Francisco.
THE MEDICAL BULLETIN
Bernard Halper is a radiologist at Hibbing, Minn. General
Hospital. He is a trustee of the Minnesota Medieal Foundation,
and is married to the fonner Barbara R. Davidoff. Their childreu
are Jeffrev, 1.5; Ross, 12; Susan, ] 2; and Lissa, 10. Thc famih'
home is ,it 341 Highland Drive, Hibbing.
.
Otto L. Hanson is a full time railroad surgeon in Topeka,
Kansas. He is chief surg~'on of the Atchison, Topeka, and Santa
Fe Railwav Hospital Association, and chief surgeon of the Eastern and 'Vestel'll Line of A.T. and S.F. The familv lives at 2322
,V. 20th St., Topeka, and includes wife Bettv, ami two children.
William E. Harris is doing general practice in association
with a three-man medical group in Missoula, Mont. He lives at
440 South Fifth St. E., with his wife, Elsie. Their son is a freshman student at Montana State Universit:" aud their daughter is
a high school sophomoJ'l'.
Ben I. Heller has been at the Veteraus Administration Center at 'Vood, ''\Tiscousin since September ], 1960, as a professor
of medicine in affiliation with the Marlfuette University Medical
School. For the five previous :'ears he was at the University of
Arkansas Medical Center as a professor of medicine. His wife
is the fonner Doris L. Tullar.
Merrill E. Henslin is in the solo practice
of general medicine in Cardeu Grove, Calif.
He lives at 9.'586 Swallow Laue. His wife's
name is June Harder Henslin. Thev have a
2:3-\'ear-<;ld son, John. Dr. Henslin was
chief of the medical staff at Palm Harbor
Hospital during 1961.
Marcus D. Hilker practices primarilv ill
obstetrics-g\llecolog.v and pediatrics in St.
Palii. H;s partuer in practice is a surgeon,
MERHILL E. IIENSLTN
Dr. P. C. Roy (Med. '35). The Hilker home
is at 94 Croeus Plaee, St. Paul 2. He aIll! his wife, Lou Aun,
have two sous.
Newell W. Howe practiccs in 'Vest St. Panl, Minu., in a IIl'\\
medical building opeued Sept. 30, 196] in association with a
partner. His home is at ] 932 Burma Lane, So. St. Paul, Milln.
He is married to the fonner Marian Penschuck, and has a SOli,
Daniel, 17, and a daughter, Barbara, 1.5.
Edgar G. Ingalls is an obstetrician-gynecologist in association with three other physicians in Minneapolis. He lives at
1901 Knox Ave. S., Minneapolis, with his wife, the former Mary
Moore, and three children.
219
THE J\IEDICA L BULLETIN
Jay Jacohy is a professor of anesthesiolog\ at Marquette
University Medical School, with offices at the Milwaukee Count\' Hospital. He came to Marquette in l().5Y, following 12 ~ears
at Ohio State University. He livcs with his wife, Helene, and
three daughters at 7Y66 N. Beach Road, Milwaukee, \Vis.
Howard E. Johnson is deceased.
Edward T. Jones has heen an ophthalmologist in Beloit,
'Vis., for the past 11 ~'ears, and taught for seven of those ~ears
at the Univcrsitv of lllinois Medical School (Chicago). He is
married to the former Helen Traub, and has three children.
Home address is 640 Bluff Street, Beloit.
Laurin J. Kaasa is a pathologist in charge of the hospital
laborator~' at the new 400-bed Memorial Hospital, Raleigh, N.C.
He moved from Midland, Mich. in August, lY(il to take his
new post whell the hospital was completecl. The famil~' home is
at :30:3 Hawthorne Road, Raleigh. "Two ~ears ago we all drove
and camped to and from Alaska, via the Alcan highway. We also
like music. Our oldest child, Bettv, 18, is a senior in high school
and pla~s cello in the Duke Universitv S~mphon~ orchestra."
Other children arc Lamin, Jr., 1.5; George, 13; Julia, 11; and
Stephen, 9. Mrs. Kaasa is the fonner Elizahl'th Bell.
"T.
Bennett
Kantola is in solo practice in Los Angeles, Calif.,
and lives at 10.30 Norman Place, L.A. 49. He sa~s he'd be "happv to meet am' classmates vacationing or living in his area."
Mrs. Kantola is named Cecil, and thcre arc four ~'()\mgsters
ranging in age from seven to 14 ~ears.
Alfred T. Kapsner is in solo general practice in Princeton,
Minn., where he operates the Princeton Clinic. "I have plenl\'
to do here and plan to sta~' until I (pdt," he said. He is married
and has five children. His wife's name is Marie.
John P. Kelly practices general medicine in Minneapolis with
an associate phvsician. He lives at .5436 Park Ave. S. with his
wife, Agnes, and children Kathleen, 17; Margaret, 1.5; John, II;
and Barbara, 8. His hobbies arc photograph~' and hunting with
the familv pet-a black Labrador dog named "Duke."
Rodney F. Kendall is a dermatologist at the Great Falls
Clinic, Great Falls, Mont., and teaches at Montana Deaconess
and Columbus Hospitals. He lives at 3251 4th Ave. S., Great
Falls, with his wife, Maxine, and two sons.
Thomas J. Kennedy is married to a classmatE', Eleanor Botha,
and is a radiologist in private practice in Denver, Colo. The
office address is 808 Republic Bldg., Denver.
220
THE MEDfCAL BULLETIN
Frank Kiesler is director of the Tri-Collllt" Mental Health
Center at Grand Hapids, Milln" and is a c1ini~al associate professor of psvehiatry at the Universitv of Minnesota, He is engaged ill a long rallge project concerned with pnblic mental
health program developmellt. The famih' home is at Pokegama
Lake. Frank's wife is named Margarct. Their children arc John,
18; alld Anne, 14.
John R. King practices derJllato]ogv allJllt, in MOlI!"oe,Mieh.
He lives at 444 Borgcss, with wife Hita, alld three children.
Henry A. Korda is a general practitioner at the Korda Clinic
in Pelican Hapids, Minn. His wife, Marcella, alld five childrell
arc all skiing enthnsiasts. Pelican Hapids, says Dr. Korda, has a
popnlation of 1,600, with good local hospital facilities.
George N. Kraemer is associated in a gronp practicc at Fairmont, Milln. His address is 1025 S. Prairic Ave. The familv inc1l1des his wife, Lois, aml Kathv, W; Bill, 14; Paul, 11; Toh'n, 8;
alld Lynlle, 4.
.
.
Clarence V. Knsz lives at 1221:5 Orchard Hoad, Hopkins,
Minn. He practices alone ill Millneapolis as a periphcral vascular disease specialist, doillg "a great amount of stripping of
varicose veins and arterial work iu the form of lumbar svmpathectomies, aortic, femoral, and iliac bypass grafts." He and
Mrs. Knsz (Marcella Olson) have "three IOYl'I.,· danghters with
the eldest, Jndith Ann, 12, doing very well as all organist."
Margaret R. Lampe practices as a general ph.vsician in association with her sister, Dr. Juliet Lampe, in San Antonio, Texas.
She lives at 90.'5 Morningside, Sail Antollio, with her hnsballd,
Col. William B. Castle.
F. John Lewis is a professor of surgel'\ at Northwestertl
Univcrsitv Mcdical School, having gOlle there in 1956 from the
facult, of the Universit', of Minnesota.
\Vhill: at Millnesota, he g:tilled acclaim for
originating tbe h''lJothennia tecllllillue
whicb is emplo''Cd ill cardiac smgerv. He
is marricd to the fonner Butb Cheska, alld
has three children. The Lunilv hOlile is at
1:345 Ashland Ave., Wilmette: Ill.
C.
WALTO~
LILLEIIEI
C. \Va!ton Lillehei is a professor of Slll'gel'\' at the University of Minnesota. He
lives at 7:3 Otis Lane, St. Panl, Miun., with
his wife, the fonner Katherine H. Liudberg,
and children Kimbel'll', 1:3; Craig, 10; Kevin, 8 and Clark, 6.
221
THE 1\1 E DIe ALB U L LET I N
Harold I. Lindeke lives at 7268 Franklin Ave., Holl\'\\ood, Calif. He practices
ophthalmolog< with offices at 1930 Wilshire Blvd., Los Angeles .57, Calif.
Bernard A. Lucking is deceasell.
11.1. LIlS"OEKE
William B. Martin has practiced for the
past ten \'ears in Duluth, MimI., as an internist and cardiologist. He lives at 2711
East 8th Street, with his wife, Doroth\
Anll, amI six children. Their ~'OI111gest w,is
born late in 1961.
James T. McMillan is a radiologist practicing with a group
of four radiologists in Des Moines, la. He is Oil the teaching
staff at Iowa Methodist Hospital. A bachelor, he has been in
Des Moines since 19,50, and has been president of the Iowa
Hac!iological Societ~'. His ac!c!ress is 28.2,5 Grand Ave.
George E. Montgomery practices in Ames, Ia" in assodation
with the McFarland Clinic. He lives at 917 Brookridge, with
wife Arline, and childrcn Marv, 1.5; George, Jr., 13; and Jo
Ann, 3.
Bernard S. Nauth is semi-retired from the practice of medicine. He now spends most of his time fI~'ing as a commercial
pilot. He lives at 6108 Hidgewa~' Hoad, Minneapolis, with his
wife, Doroth~'. The~' have two daughters and two SOlIS.
Gerhard Nesse is deceased.
Marsh O. Perkins is in practice alone in anesthesiology and
lives at 17.5.5 Hio Vista \Va~' S., Salem, Oregon. He was a general practitioner in Lebanon, Ore. from 1946 to 19.56, when
he took a residency at the Universit~' of Oregon anc! later began
a practice in anesthesiolog~' on the staff of the Salem Memorial
Hospital. His wife is the fonner Doroth~' Ann Nelson. Thev
have three sons.
Herschel L. Perlman is in general practice with a partnerph~'sidan in Minneapolis. He lives at .50.'57 Gladstone Ave. S..
with wife Charlotte, and children Stephen, 1,5; Glen, 14; and
Marl~'s, 11. He spent 3)~ years on duty in \Vorld \Var II, and
completed two ~'ear residencies in obstetrics-gvnecologv and
internal medicine prior to beginning his present practice.
John W. Peterson is an ophthalmologist in Carbondale, 111..
living on Houte No.4, Carbondale, with wife Alvina (Pederson)
and five children. He was in the U.S. Armv from 1942 to 1946.
and trained for ophthalmolog~' at the Presb~terian Hospital and
222
THE MEDICAL BULLETIN
Illinois En:' and Ear Infinnarv, Chicago
until 1~H~J. He is also a consultant in ophthalll1olog\' to the Veterans Administration.
KENNETH PETEHsO .....
Kenneth A. Peterson practices at Marshall, Minn., in association with two other
Minnesota graduates, John E. Eckdale
(Me(!. '40) and Burton C. Ford (Med. '21).
The\' moved into newlv built offices in
19.'59. His family includes wife Stella, two
daughters, and' one SOIl. "The famih' enim 's western saddle horses. \Ve owu three."
H'OIne address is 10,'5 Hill' Street, Marshall.
Thomas G. Petrick is associate pathologist at the Municipal Hospital, Virginia,
Minn. He lives at 222 Garfield Street, Evcleth, Minn. \Vith his wife and two SOIlS, he
resettled in northern Minnesota to "enjm'
fishing, hunting, skiing, and swimming-the
favorite famih' pastimes." He formerh
practiced in New Jersev.
Harold G. Ravits is head of the Department of Dermatologv at Ancker Hospital,
St. Paul, and a clinical assistant professor
TlIOJ\L\S C. PETRICK
at the Universit\ of Minnesota. He 11<Is a
.
private practice in St. Paul as a dermatologist. The !'amil\' includes his wife, Lenore, and children Martha, II; Emil v, 9;
and John, 8. Home address is 235' Mt.
Curve Blvd., St. Paul.
Norton D. Ritz lives in New York Cit\
where his practice is primarilv in hemntoiogv. As a clinical assistant professor of
medicine at State University of New York
Medical School, he is con(!ucting research
in hemophilia, fibrinol~'sis, and Ivmphomas.
HAHOLD HAVITS
Home address of 2729 Bedford Ave., New
York City, is shared bv his wife, Shirk\', and children Ilene,
]''5; Sara{anc, 13; and Bruce, 10.
'
Robert T. Rowland is an internist in solo practice in San
Diego, Calif. He lives at 4126 Palisades Road, San Diego 16,
and teaches at San Diego General and Merc." Hospitals. His
223
THE J\IEDICAL BULLETIN
wife is the former Kathrvn Egan. The\' have a danghter, Kathy,
1:3.
John F. Schmid is a dermatologist in solo practice in Duluth,
Minn. He is a past president of the Minnesota Dermatological
Society, and a member of the American Academv of Dermatologv. He and his wife, Avis, have four children; the oldest of
whom is a stndent at the Universit\' of Colorado. Dr. Schmid
teaches at St. Lnke's and Moose Lake State Hospitals. Home
address is 2.520 E. Seventh Street, Dnluth.
Yerne A. Schulberg is a partner in practice with his classmate, Frederick Closuit, at the Aitkin Clinic, Aitkin, Minn.
Verne and his wife, Merle, havc a SOlI, Peter 22, and daughter,
Alldrea, 2:3.
Golden Selin is a pathologist associated with thc Allentown,
Pa., Hospital Associatioll. He lives at 4::34 Leh Strect, Allcntown,
with his wife, the former Lois Hokanson.
John J. Sevenants is a dermatologist in LaCrosse, \Vis., living at 218 ZephYr Circle with his wife, Marion, and two ehil(hen. He practices solo and teaches at the St. Francis School of
Nnrsillg.
J. Donald Sjoding is associated with the Mankato Clinic,
Mallkato, Minn., with practice limited to otolarvngolog~' amI
brollchoesophagolog\'. The familv home is at ('l.S SkdinE' Drive,
Mankato, and houses his wife, Alice, and childrcn Carl, 17;
Donna Tean, 14; and Carol Ann, 14. He served as an Air Force
officer i;l the China-Burma-India theater during \Vold \Var II.
Benjamin C. Sloan practices with a group in Los Angeles,
Calif. He lives at .560 Loring Ave., with his wife Mar~'ann, and
son Peter, 14; and Nancy, 12. He spent three ~'ears in militan'
scrvicc during \Vorld \Var II, and "rcgrets hc could not take
work at University of Minnesota following dischargc."
Stanley P. Stone practices gcncral mcdicine with a group in
two locations in Minncapolis. Hl' lives at 14:30 Angelo Drive,
Minncapolis 22, with his wife, Barbara, amI thrce children,
Pde'r, lfi; Virginia, 14; and Paul, 10.
Jacob H. Strickler is a gencral surgeon and clinical instruetor at the Univcrsit\· of Minnesota Medical Schoo!. His partner
in private practicc is Dr. CarlO. nice (Med. '25), also a surgeon.
TIll' Strickler homc is on Houte No. 1, Excelsior, Minn. Mrs.
Strickler is tIll' fonner Helcn Mitchel!. The\' havc two sons,
Jdfre~', 17; amI John, 14.
Gerald J. Taylor practiccs "mostll' in the fidd of religion
and psvchiatry." Hc livcs at 1155 Park Avenue, New York City
224
THE MEDI.CAL BULLETIN
28, New York, with his wife, Katherine (McLean). His psychiatric practice is solo.
Max M. Tenen died Mav 11, 19G1 in Downe~', Calif.
Ramona L. Todd is senior phvsician and surgeon in the
geriatrics program at the Napa State Hospital, Imola, Calif.
Her address is 2120 Buhman Ave., Napa, Calif. At work, she
supervises the medical and uursing staffs of 12 wards aud a total
of 1,067 beds, as well as a speeial project of intensive treatment
and rehabilitation of patients past G.'5 veal's of age. In off-dnt~'
hours, she "enjoys a ranch of 10;) acres and dot'S some investing
in California real estate."
Richard B. Tudor is a Minneapolis pediatrician with downtown and suburban offices. He also teaches at the Universitv of
Minnesota and several hospitals. "Not 111l1ch
time for recreation," he savs, "but I manage to plav tennis twice :1 week in summer." He'd be interested to hear from classmates, especiallv out of towners when the."
visit Miuneapolis. The familv home is at
.'520 I Minnehaha Blvd. He and wife Charlotte have three daughters, thc oldest of
whom is a freshman at the Universit." of
(:olorado.
.
HICIf..\HD B. Tunon
Lewis A. Vadhcim moved to Pomona, Calif., in H).'51 to
begin a practice in general surgen'. He's still there. After Am1\'
service 1942-4G, he was a Man) Foundation fellow in surger~',
acquired a wife (the former Constance M. Dav), and now has
three children: Constance, 12; Timothv, 9; and Nancv, .'5. Home
address is 18:32 American Ave., Pomo{la.
.
Frederick n. Van Bcrgcn is professor
and head of the Department of Anesthesiologv at the Universit\' of Minnesota Medical
School. His address' is P.O. Box 294, Universil.\' Hospitals, Minneapolis 14, Miun.
He enjcH's hunting amI fishing when time
permits.
Gcorgc T. VanHooy is assoeiated with
the Falls Clinic, Thid HiveI' Falls, Minn.,
and lives on Oakland Park Road in that
F. H. VAN MERGEN
northw{'stem Minnesota commnnitv. He is
married to the fonner Marvel GI:ovum, and has a daughter,
Penelope, 11.
225
THE 'MEDICAL BULLETIN
George L. Walker is a general surgeon in Detroit, Mich. He
practices alone and teaches at the \Va\ne Universitv College of
Medicine. He is married to the former Jane \Villiams, and has
three children, Maril~n, 13; Kathleen, 11; and George, 9. The
famil~' home is at .'561 Peach Tree Lane, Grosse Pointe 36, Mich.
Edward F. Walsh limits his practice to pediatrics. He is with
a group of three other pediatricians practicing in St. Paul, and
he teaches part-time at the Universih' of Minnesota Medical
School. Home address is 1401 Forest Lane, St. Paul 12. His
famil\' includes wife Alberta Hush, four daughters, and one son.
Richard J. Webber is a surgeon associated with the 26-man
St. Louis Park (Minneapolis) Medical Center. He was in military
service 1942-4.'5, and was a surgical resident at Minneapolis
Veterans Hospital 1946-.'50. The Webber home is at 18101 \Voolman Drive, Excelsior, Minn. Married to the former Marv Lee
Moore, he is the proud father of Caroline, 16; Alison, 14;' Richard, 13; Deborah, 11; and Quintus, 6.
Elaine \Ventink is in general practice in \Vashington, D.C.,
at a combination home-office at 4812 Ellicott St. N.\V. She's
the wife of Dr. John C. Murphy, a surgeon, and the mother of
John, Jr., 16, who "wouldn't mind being a doctor, but would like
to work from 9 to .'5."
George T. Wilson is a dermatologist in Palo Alto, Calif., and
teaches at Stanford University Medical School. He is a diplomate of the American Board of Dermatologv, and lives at 330
Golden Hills Drive, Portola Valle\', Calif. The whole famih'
(Suanne, 18; Heather, 1.'5; Hollv: 12; Keith, 10; and wife,
Rhoda) piled into a trailer last sl;mmer and visited Minnesota,
Quebec, and the East Coast, before returning home. They're
veterans of the open road on skiing trips. Dr. \Vilson has been
affiliated with Stanford University since 1949. "Mv research
interest is c\'tolog\' of skin tumors-the thesis of m\' M.S. degrec at Minnesota in 1949."
The editors express their thonks to oll who
contrilmted information and pllOtos for this
article. Next: The Closs of 19.31.
226
IMedical Foundation News
MEDICAL FOUNDAnON ANNOUNCES
NEW MEDICAL RESEARCH PROGRAM
Establishment of a permanent new medical research program
was annollnced Januarv 1.5, H)62 bv the Mimlesota Medical
Foundation.
.
.
Dr. Arnold Lazarow, Foundatiou president, said grants were
now being offered for research conducted
bv faeultv and studellts of the U niversitv of
Minnesota Medical School in the basic a'reas
of heart disease and cancer. The program is
endowed principally by a legacy of $200,000
received bv the Foundation last year. The
donor was 'the late Arvid Olson, New Town,
N.D., killed in a 19.'57 allto accident, who
left the major portion of his $700,000 estate
to educational, scicntific, and research purposes.
The Foundation will make available up
to $10,000 each \Tar llnder the new proAHI\'OLD LAZAHO'V
gram, Dr. Lazarow said. "The major objective is to provide local aid for \'oung scientists who have promising research ideas and
projects meriting support," he declared. 1nstrllctors, residents, interns, research assistants, and mcdical stlldents arc eligible to
apph', as well as established faelllt~· researchers who have special needs for local
funds. Three awards of $1,200 each will be
set aside annuallv for medical students.
Dr. PallI D. 'Bo~'er, professor of phvsiological ehcmistrv, was namcd chairman of
the Foundation's COlllmittee on Research
Grants, which will evaluate re<llwsts for
funds.
PAUL D. BOYEH
The FOllndation awarded $4,7tl4 in research grants to four
faeultv members dming 1961. It also distributed $26,2.50 in
scholarship awards to fifty medical students.
227
~I
T :\' :\' E SOT A
~I
EDT CAL
F 0
(T
N DA T TON
/ - - - - - STATEMENT OF CONDITION°
As of September 30, 1961
ASSETS
1961
Current Funds
Cash Oil halld
Cash ill Ballk~CI)('ckillg
Cash ill Ballk-Savillgs
i\lilll1csota i\ll'dical FoulIdatioll
Exccutin' Officc Accollut
with Ullin'l'sit\, of i\liullcsota
Notc Rccci\'ah1l'
IUH'StIlH'lItS
Gcueral Agellcy Accouut
~ !l'dical Hesl'al'ch Fllnd
,1),00
iii
19HO
iii
ICUS5.14
11,Oll.lU
S.OO
H,H\):3.24
1O,(j:H.ll
70S.HD
1;-)7.U7
7:32.fH
100.7,1
:)O,(1~U:3
1m, I ,j(j.0(j
.'32, 150.D6
0.00
ili2.55,H,'5H.7H
iIi,S2,8UCUJD
:j;
,I,I-'HO.HG
:j; 4,8HO.8Cj
·10,000.00
40,000.00
Endowment Funds
Cash in Bank-Chccking
InvcstIllent
Gencl'al Agl'IICy Account
-~---~--
:j;,14,HHO.H(j
$44,8HO.H(j
----TOTAL ASSETS
$:300,740.G4
$97,777.1'.'5
A MEMORABLE YEAR
The Mill/Iesota Medical FO/Illda/ion has cOlnplded its secowl year
of 0IJeratim/s /Illder filii time direction. The fiscal year ended Septem~
bel' a/), 1961 leas IIlllrked liy a triplillg of FOlllldation assets, thallks
largely to a IIlllior legacy recei!;ed for heart awl Clllicer research IHII'poses. The FOlllldatiOlI III11C has a lIet Icorth of $,]/}(),7,j/}'(j.l, as sllO/cn
bll the cowlellsed alldit IHllJlished almcc,
111 cOIllldetillg its secOlld 'lear of filii timc IJrogl'lllllllling, the 1"01111dation also reached a so light-after goal: Ullrestricted-llse gifts awl
dlles from I/Iemliers alld friends exceeded Im,"ic operatillg cXIJenses.
This sigllificant attaill/nent is er;idenee of the renlllrkah!e IIIJsllrge ill
illtcrest and loyaltll al/long old ami nelc IJlCmliers ami other friends
of tllC Medical School.
1I1illtlesota Medical FOII/ldation illCOIIIC from al/ sOllrces and for
al/ I'lIIposes dllring fiscal 1.';Hil ((;as 8281,555.84. Of this Sllln,
221'
~r
I .'1/ I\' E SOT A
\I E D [ CAL
]7
0 U I\' DA T ION
STATEMENT OF CONDITION" - - - - - .
As of Scptcmhcr 30, 19(jJ
FUND BALANCES
Currcnt Funds
UnH·strid,·d funds
R"strid"d funds
19fil
1960
.'3H1.74
$ 4,.'5D7.:3.5
2.5.5,47H.04
4H,2mJ.64
$255,H,'5D.7I'
$.52,HD6.DD
$ 40,5,'56.H6
$40,.'556.H6
4,:324.00
4,,'324.00
$ 4'l,HHO.H6
$44 ,HHO .Hfi
$:jOO,740.G4
$D7,777.H5
$
Endowmcnt Funds
UllI""strid,·d funds s"rvin,~
as ('IHIOWnH'nt
S"holarship fuuds
TOTAL FUNDS
I)
Audit by Tlwo<1ort, Stark & Co., C('rtifi{'d Puhlit: Accountants,
~filllH'ap(}lis, Xfinn.
$257,557.RrJ ICIIS design lit I'd for sjiCcific jJW;ccts blj donors,
$2.'3,rJ.'J7.!J5 WIIS cOlltrilJllted IcitllOllt restrictioll as to IISC.
IIlld
'Vith CI)[;e/'{/ge of hasic costs nIHc 11.1'.1 11I'cd, the FOllndatioll looks
IIhelid to the all;)('atiIJl! of //lost flit 111'1' IIllrestrictcd gifts to the {;ariOilS jiwgr([)lIS ill fiwgress or 1II111er deec/ojJllu'nt hlj the FOllndatioll's
T1'llstecs. All FOlllllilitiOll efforts 111111 IIssets lire dedicated to tlte Sllfil}(}l't of the Unil;ersillj of Minlll'Sotli Mcdiclil ScllOol.
Other higlrlights of tlU' j)(lst Ijellr il/{'!rllle:
• The issll([)ll'e of II third IJistingllislll'd Scrcice Aluml to a fllellltlj
//Icmhl'r, glw/'{/Ilteeing $5,000.00 IIll1l/wlly IIntil retiremcnt for the recifiicnt. Dr. Cecil ]. 'Vat,I'OII ICIIS llOllOrcd tcitll ([)l alCard financcd in
filII hlj a $40,000 ('omlllit/lU'llt fWIII the ]([)/Ies Ii. Bell FOllndlitiOlI of
Millllellj}(}lis.
-Continller! 011 llc:rl page
229
THE
},I
E DIe ALB U L LET I N
(Continlled from prc('cclillg page)
• Thc distrilJlltiOlI of a rccord $26,2.50 ill scllOlars1lip aid to fifty
medical stlldellts. This lUIS made I)()ssihle IJy the gellcl"olls cOlltl"ilJIItiOllS of fricllds, firms, mcdical clillics, medical ol"gallizatiOlls, alllllllli,
allli othcI" fOll/nlatiolls.
• '''e cClIltrilJllted .'!i-J,205.62 to aid pllblicatioll of the mOllthly
Ullicel"sity of ,Uillllcsota "fEJ)ICAI~ BULLETIN, co-pllblished lI;ith
Ullicersity Hospitals, as Icel/ as WPIJlyillg completc editorial alld circldatioll IllCl/lligemCllt.
• LoallS of .'!i11,555 lU'I"e madc to 97 medical stlldclltS fO/' emcrgellcy IJlIrposes, IcitllOlit illterest charges alld lcitllOlit loss to delillI/Ilellcy, Iltilizillg a $-J,OO(J flllld IJl'Ocided hlj the Minllcsota State
Medical Associatioll.
-
EI\'INll HOFF,
JR.
Excclltire Secrctary
• 19:;9 '
230
Editorial
The Onan Professorship in Surgery
Creation of a professorship is alwa~~s a signal event in the
history of any school, for the endowment of men generates the
true spirit of the University. This spirit enables the transforming influence of the teacher to reach out and touch the lives of
countless men in many generations. \Ve in our Universit~~ of
Minnesota Medical School were privileged in 1961 to receive
an outstanding professorship in surger~', established b~' the
Onan family of Minneapolis. Gratefull~· we acknowledge this
gift of unusual prescience to our great University. Reflecting on
the wisdom of Sir \Villiam Osler when he admonished his students and colleagues some veal'S ago, we realize how deeplv
prophetic were his words:
"The physician needs a clear head and a kind heart; his
work is arduous and complex, requiring the exercise of
the rery highest faculties of the mind, tchile constantly
appealing to the emotions and finer feelings. At /10
time has his influence been more potent than at present,
at no time has he been so pOlce/ful a factor for good,
and as it is one of the highest possible duties of a great
Unirersity to fit men for this calling, so it will be your
highest mission, students of medicine, to carryon the
neuer-ending tcarfare against disease and death, better
equipped, abler men than your predecessors, but animated with their spirit and sustained by their hopes,
'for tIl,? hope of euery creature is the banner that Ice
bear.
Sir William Osler
.\fcGilI .\IeclicaI SehooL 1894
More truly today than ever before, the lamp of medicine is
shining into the remotest portions of the world as a common
succor tending to bind all men together in an intangible but
effective bond of common fellowship.
It may well be the balm of our ancient and noble profession
which will finally crown with success the efforts of generations
upon generations to bring to equal flower all of the peoples and
nations of the world as they struggle to be enlightened and free.
Realizing the present need for more and better trained phvsicians and cognizant of increasing demands for large numbers
231
THE
~IEDICAL
BULLETIN
of teachers of medicine in our medical schools, what greater
service could be rendered than provision for a professor in the
future of the teaching effort! With the humility of sincere thankfulness and, stirred with enthusiasm for an ever brighter future
of our school, we recognize the wise and realistic purpose demonstrated in the details of the "Onan Family Professorship."
The Onan Family Foundation will provide annuall:-· to the
University of Minnesota monies to include a basic salary of
$20,000 per :-'ear for their professorship, percentage increases
in salarv which will be decided in accordance with the University's salary policy for the year in question, and the ancillary
costs of Social Security and other fringe benefits. This generous professorship has been established to begin January 1,
1963 for the initial period of ten years with intent of continuity
thereafter.
According to the wishes of the members of the Onan famil:-',
their professorship will be used for the Assistant Director of
Surgery at the Minneapolis General Hospital in the Universitysponsored training program. \Vith full appreciation of the invaluable contribution of our outstanding municipal hospital to
the academic vigor and well-being of the medical students of
~Iinnesota, the Onan family is realistically and effectively aiding
academic surgical teaching in the state through this medium.
\Ve have long recognized the dependence of the medical
student upon a rich and varied clinical experience for ultimate
excellence as a physician. \Vise and sober reflection leaves no
doubt of the goal we must continue to seek by preservation of
the noblest principles of medical instruction through guided
patient contact.
"The most essential part of a student's instruction is
obtained, as 1 beliet:e, not in the lecture room, but at
the bedside. Nothing seen there is lost; the rhythms of
disease are learned by frequent repetition; its unforeseen occurrences stamp themselt:es indelibly on the
memory. Before the student is au;are of u:hat he has acquired he has learned the aspects and causes alld probable issue of the diseases he has seen tcith his teacher,
m.nl the proper m2de of dealing u:ith them, so far as
ll1S master knou:s.
Olit:er Wendell Holmes, 1867
\\'e can best evidence our deep appreciation for the exemplan' contribution of the Onan family with renewed determination to diligently seek further for similar academic support,
so characteristicall:-' American in its concept. \Vhen so much of
232
THE MEDICAL BULLETIN
om present day is beclouded with critical issues threatening to
engulf men everywhere, the heart is quickened and we are inspired with this evidence of a desirc to build in the greatest
area of human achievement-the acqnisition and the dissemination of medical and smgical knowledge!
R. HITCHOCK, M.D., '44
Professor of Surgery
-CLAUDE
REHABILITATION HOSPITAL
TO BE BUILT AT UNIVERSITY
Regents of the Universit\, of Minnesota have given their approval to plans to build a new pediatric rehabilitation hospital
at the Universitv's J\[edieal Center.
The new $1,940,000 structme will rise on the hillside just
south of the present Students Health Service, and be connected
with the Universitv of Minnesota Hospitals and the Medical
Schoo!. It will have six floors which will house two 20-bed
wards, one for children and one for adults; laboratories, offices,
and classrooms, Construction is expected to begin in 1962, with
completion and occupanc\' auticipated bv late 1963, according
to Dr. Frederic J, Kottke, Professor and Director of the Department of PI1\sical Medicine and Rchabilitatiou.
The new hospital will serve patients with skeletal problems
who are in the transitional period between acute hospital care
and independence at home. In addition, it will provide rehabilitation training for doctors, nmses, therapists, vocational COIIllselors, and social workers.
Federal funds covering 4,,) per cent of the total construction
cost will be provided under the Hill-Burton hospital construction
aid act. The Universitv's Eustis Fund, a private endowment
provided b~· the late \Villiam H, Eustis, former mayor of Minneapolis, will furnish the remainiug ,5.5 percent.
2:1:1
THE MEDICAL BULLETIN
-MinnelJpolis Tribune Photo
GEORGE E. F AHR HONORED
Two hundred friends, colleagues, and former students from
throughout the United States were present to Iwnor Dr. George
E. Fahr, professor emeritus of medicine, as his portrait was unveiled and presented to the University of Minnesota on .Ian. 27.
The formal banquet climaxed a day-long observance of Dr.
Falu.'s 80th birthday, including a scientific program prescntcd
by his former students. He was a faculty member for 2R years,
teaching at Minneapolis General Hospital. The portrait was
commissioned through contributions of individuals to the
George E. FalH Fund of the Minnesota Medical Foundation,
and painted by Mr. Theodore Sohner, Minneapolis, for thc
occasion. Dr. Robert,B. Howard, Dean of the Medical Sciences,
accepted the portrait for the University. It has been hung at the
Meclical School.
Dr. Howard B. Sprague, Boston, Mass., cardiologist, was
main banquet speaker, and Dr. Arthur C. Kerkhof, Minneapolis, was master of ceremonies.
A George E. Fah,' Festschrift was published for the occasion, containing a full color -reproduction of the portrait, and 21
scientific papers. A limited numbe,' of copies are available lit
$.5.00 each, postpaid, on order from the Minnesota 111 edical
Foundation, 1342 Mayo Bldg., University of Minnesota. PTOceeds of the observance (lnd sale of the festschrift go to the
George E. Fahr ScholO1'ship Fund of the Minnesota Medical
Foundation.
234
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Medical School News
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DR. RAYMOND BIETER TAKES
NEW MEDICAL SCHOOL POST
Dr. Ravmond N. Bietcr has been named Health Carcers
Coordinatoi· and Director of the newlv-created Division of
Special Educational Services of the Ulliversity of Minnesota
College of Medical Sciences. He will relinlluish his post as Head
of the Department of Pharmacology as soon as a succcssor is
named, and has alreadv assumed the duties
of his new position. .
In making the appointment, Dr. Robert
B. Howard, Dean of the College of Medical
Sciences, said Dr. Bieter would plan and
coordinatc a program at thc University,
state collcges and univnsities, and high
schools for dissemination of information on
careers in the health sciences. He will visit
campuses and schools regularly as the official rcpresentative of the College of Medical Sciences.
"Dr. Bieter's rich background as teachcr,
RAYMOND N. BIETEIt
investigator, and department hcad makes
him unnsually well qualified to fill this important ncw post,"
Dr. Howard said.
Dr. Bieter will also coordinate the Universitv's combined
M.D. - Ph.D. training program sponsorcd by the' U.S. Public
Health Servicc. This seveu-year curriculum prepares a studeut
for an academic career in medicine by providing complete
M.D. tmining as well as a Ph.D. degree in a basic science.
Dr. Bieter will also have similar responsibilities for the postsophomore research fellowship program and will be generally
responSible for information services to prospective students in
all of the health fields. He is a 1923 graduate of the Medical
School, and joined the faculty in 192,5, becoming heacl of the
Department of Pharmacology in 194.3. A committee has been
appointed to seek his sm:cessor in that position.
GOLF WINNINGS DONATED
Patty Berg, fonner M inneapolitan and freqnent champion
of the ladies professional golf world, donated her prize mone~'
from the recent Haig and Haig mixed foursome tournament
held in Florida. Her generous gift to the University Hospitals
was $1,329.00.
2,3,5
T II E
~I
ED I CAL B U L LET I N
RESEARCH EQUIPMENT
DONATED TO UNIVERSITY
A recording oscillograph and other scientific equipmcnt
worth $5,300 has been donated to the University of Minnesota
~1edical School bv the Consolidated Electrod\'namics Corp"
Pasadena, Calif Dr, Marvin Bacaner, associate professor of
physiology, will use the efluipment in heart and circulaton
studies conducted in the Department of Ph~'siolog~', He joined
the Universit~' facult~, in August, 196L
NEW GRANT FOR RHEUMATIC DISEASES
RESEARCH
The search for a possible common link among a variet~' of
so-called "rheumatic diseases" will continue in 1962 at the
Universit~' of Minnesota under a new $53":514 rescarch grant
from the National Foundation,
The work will be directed b~' Dr, Hobert A, Good, profcssor
of pediatrics, at a special Children's Hheumatic clinic at Universitv Hospitals, which deals with a host of rheumatic anel
arthritic conditions, Among ~'Olmgsters fol!owed b~' Dr, Gooel
and his associates are about 130 with juvenile rheumatoid
arthritis,
The continuation stud\' was made possible by public contributions to the March of Dimes.
DIABETES RESEARCH GRANTS AWARDED
The Twin Cities Diabetes Association has awarded $1,200
to the University of Minnesota for support of three research
projects in diabetes.
Sharing in the awards arc Dr, Hichard DeWall, instructor
in surger~', for research into "Homotransplantation of Pancreatic
Islet Tissue;" Dr. Carl B. Heggestad, assistant professor of anatom\', for "Determination of Corticosterone Levels in the Sera
ami Adrenals of Diabetic Pregnant Hats;" and Jack Cooper,
medical student, for "Quantitative Evaluation of Blood Vessel
Alteration in the Hetina in Human and Diabetic Subjects and
in Experimental Diabetic Animals."
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• 1921
Raymond J. Dittrich has joined the staff of the Cambridge
(Minnesota) State School and Hospital. He was fonnerlv associated with the Veterans Administration Hospital, Iron Mountain, Mich.
• 1923
Alfred L. Lindberg has retired after :37 \"('ars of medical practice in \Vheaton, Minn.
• 1924
Arild E. Hansen, California pediatrician, has been honored
bv the Universitv of Texas Medical School at Galveston, which
h:1S named a pel:ll1anent series of annual lectures for him. He is
director of research at Bruce Lnm Memorial Research Laborator.", Children's Hospital of the 'East B~l\. Oakland, Calif.
• 1928
L. Raymond Scherer of Minneapolis was elected president of
the Minnesota Socieh' of Internal Medicine for 1962.
• 1935
Albert S. Brussell is assistant chief of the outpatient service at
the Veterans Administration Hospital, Dallas, Texas.
Harry B. Hall, Minneapolis orthopedic surgeon, spent Januar." amI Febrnary on volunteer duty with Project Hope in
Southeast Asia. He engaged in rehabilitation work in teaching
hospitals in Saigon, South Viet Nam, and Djakarta, Indonesia, in
compam' with his son, John, 19, a ph,'siotherapist. Dr. Hall is
head of the rehabilitation center at Fairvit,w (Minneapolis)
Hospital.
• 1936
Lawrence Berman was recenth appointed chairm'll1 of the
Department of P,ltho]og', \VanJ(' State Universitv Medical
School, Detroit, Mich.
• 1943
Clark ,V. Truesdale has returned to full time practice in Glencoe, Minn., following two ."ears on the staff of the Veterans
Hospital, Miuneapolis.
• 1946
Ray C. Anderson, associate professor of pediatrics at the Universit" of Minnesota Medical School, received a Distinguished
Alumnus citation from Gustavus Adolphus college, St. Peter,
Minn.
2:37
THE MEDICAL BULLETIN
• 1946
George E. Moore, director and chief of
surger~' at Roswell Park Memorial Institute,
Buffalo, New York, was one of the ten winners of 1962 Distinguished Achievement
awards presented by the editors of Modern
Medicine. Dr. Moore was specifically honored for oustanding work on the causes and
treatment of cancer, and as a research coordinator for chemical treatment of cancer.
His work and interest in cancer stem
from his training at the Universit~· of Minnesota, and his research done as faculty
GEORGE E. MOORE
member. He moved to his present post in
Buffalo in 19,52, becoming director and chief of surgery at the
age of 32, The cancer research institution now has 300 beds and
] ,750 emplo~'ees,
• 1950
Harry J. Smith of Lake Crystal, Minn" was elected 1962
president of the medical staff at Immanuel Hospital, Mankato,
Minn, The retiring president is Dr. A. M. Scheidel of Mankato.
• 1951
Donald E. Wohlrabe of Springfield, Minn., has been inducted
as a fellow of the American College of Surgeons.
• 1956
Lt. Sam Assam is nO\\7 on duty with the U.S, Navy Medical
Corps at the Naval Hospital, Chelsea, Massachusetts.'
• 1957
George E. Jackish is now associated with the Interstate Clinic
of Red Wing, Minn., in internal medicine. Dr. Ralph R. Rayner
(Med. '52) is also a new member of the clinic's medical staff.
He fonnerh' practiced in St. Paul.
• 1958
Joseph S. Drage, Jr. was married January 6, 1962 to Mary
Carolyn Hardegree in San Angelo, Texas. They are now living
at 2421 Pillsbur~' Ave., Minneapolis, Minn. Both are residents
in pediatrics at the University of Minnesota Medical School.
The bride is a graduate of the Universit~· of Texas Medical
School.
• 1960
Lt. Alan R. Johnson has completed training at the Naval
School of Aviation Medicine, Pensacola, Fla., and has been
transferred to sea dut~· with the U.S. Marine Corps in the Pacifie
oeean area.
238
T II E },[ E D [C ALB U L LET J N
ALUMNI DEATHS
• 1907
Dr. E. Mendelssohn Jones, St. Paul, Minn., surgeon, died
December 7, 1961 after a prolonged illness. His medical career
included a term as chief of staff at St. Paul's Ancker Hospital;
the presidencv of the Minnesota State Medical Association and
the Hamse~' Countv Medical Societv; and active membership in
the American College of Surgeons and Minnesota Academy of
Medicine. He was a member of the Minnesota State Board of
Medical Examiners, and a clinical professor emeritus at the
Universitv of Minnesota Medical School. Dr. Jones is survived
by his w(fe and a daughter.
.
• 1934
Dr. Rolland E. Keefe, ,'54-\'l'ar-old staff ph~'sician at the Anoka
State Hospital and practicing St, Paul phvsician, died December 1, 1961 of a heart attack. He was ,'54 \'ears old. Dr. Keefe
was a member of the American Medical Association. His survivors include his wife and one SOIL
Memorial Gifts
Memorial gifts to the Minnesota Medical Foundation
have been received recently in memory of:
Miss Meredith E. Anderson
Evanston, Ill.
Mr. Jeff Couch
Minneapolis, Minn.
Mrs. Ray J. Quinlivan
St. Clond. Minn,
Memorial contributions are a practical means of honoring the memory of a friend or loved one, while helping the
Minnesota Medical Foundation in the advancement of
medical education and research. Appropriate acknowledgements are promptly sent to both donor and family of the
deceased,
239
THE MEDICAL BULLETIN
MEDICAL ALUMNI
Send your personal news to the MEDICAL BULLETIN
on the form below. Your contribution to "Alumni Notes" will
be welcome.
Name
'
,-
Address .,
Class of
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,
.
. -
.
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Detach and mail to: The Editor
Universitv of Minnesota MEDICAL BULLETIN
1342 Ma~o Memorial
Universit~ of Minnesota
Minneapolis 14, Minnesota
240
COIning Events
University of Minnesota Medical School
List of Continuation Courses for Physicians
University of Minnesota
Center for Continuation Study
1962
All Year
Caneer Detection for General Physicians
Fcbruary 12-14
Pediatric Neurology
March 5-7
Anesthesia for General Physicialls
March 16-17
Treatmellt of Traumatic Injuries
April 12-14
Otolaryngology for General Physicians
April 16-18
Internal Medicine for Illternists
April 26-28
Surgery for Surgeons
April 30-May 2
Gynecology for General Physicialls
May 7-9
Ophthalmology for Specialists
May 14-18
Proctology for General Physicians
May 31-June 2
Psychiatry for General Physicians
The University of Minnesota reserves the right to change this schedule
without notification.
Courses are held at the Center for Continuation Study or the Mayo
Memorial Auditmium on the campus of the University of Minnesota.
Usual tuition fees are $30 for a two-day course, $50 for a three-day
course, and $75 for a one-week course.
Specific announcements aru sent ont abont two months prior to eaeh
eoursc to all members of the Minnesota State Medieal Association and
to any physicians who request information for a specific course. For
further information write to;
DIHECTOR
DEPT. OF CONTINUATION ~[EDICAL EDUCATION
THE MEDICAL CENTER
UNIVERSITY OF MINNESOTA
MINNEAPOLIS
14,
.\hNNESOTA
lMIM,*""",
li
'""
iffl)'
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it
it
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Memorial Gifts
t,·
Second Closs Postage Paid
at Minneapolis, Minnesota
Memorial gifts are popular means of paying thoughtful tribute to
the memory of a relative, friend, or colleague.
Your Minnesota Medical Foundation welcomes memorial gifts, and
makes immediate acknowledgment to the family of the deceased, and
to the donor.
Contributions are used to help finance the programs of medical
education and research conducted by the Minnesota Medical Foundation in behalf of the University of Minnesota Medical School.
Gifts may be sent to:
Minnesota Medical Foundation
1342 Mayo Memorial Building
University of Minnesota
Minneapolis 14, Minnesota
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PRES.
202
O.
ADM.
MEREDITH
BLDG.
WILSOlll
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