Symposium on Phylogenetic Approaches to Innate Immunity INSTITUTE OF MEDICINE - FORUM ON MICROBIAL THREATS 2-3 December 2014 DAY ONE: TUESDAY, DECEMBER 2, 2014 8:30 – 9:00: 9:00 – 9:15 Registration and Continental Breakfast Welcoming Remarks & Overview: Drs. David A. Relman, James M. Hughes, Lonnie J. King SESSION I: OVERVIEW OF THE INNATE IMMUNE SYSTEM IN PLANTS 9:15 - 10:00: 10:00 – 10:30: Moderator: Peter Daszak Innate immunity across host domains David Schneider, Stanford University Host-microbe interactions: shaping the evolution of the plant immune response Gitta Coaker, UC Davis 10:30 – 10:45: BREAK 10:45 – 11:15: 11:45 – 12:15: Interplay between innate immunity, pathogenesis, and the plant microbiome Sheng Yang He, Michigan State University/HHMI Genomic approaches to plant disease resistance Richard Michelmore, UC Davis DISCUSSION 12:15 – 1:00: LUNCH SESSION II: OVERVIEW OF THE INNATE IMMUNE SYSTEM IN INVERTEBRATES: C. elegans/Insects/Corals 11:15 – 11:45: 2:30 – 3:00: Moderator: David Relman Host-microbe interactions and microbial recognition in a simple nematode host Dennis Kim, Massachusetts Institute of Technology Parasite-host-microbe interactions shape the evolution of the insect innate immune response Shirley Luckhart, UC Davis Insect antiviral innate immunity: pathways, effectors, and connections Richard Hardy, Indiana University DISCUSSION 3:00 – 3:15: BREAK 3:15 – 3:45: 5:15 – 5:45: Evasion of insect immune defenses by parasitoids Michael Strand, University of Georgia Anticipatory immunity and counteracting Plasmodium immune evasion strategies in A. gambiae. George K. Christophides, Imperial College London Microbial community structure of Florida coral reefs and their role in disease resistance Kim B. Ritchie, Mote Marine Laboratory The role and function of NLRs in the innate immune response Jenny P-Y Ting, University of North Carolina DISCUSSION 5:45: ADJOURNMENT 1:00 – 1:30: 1:30 – 2:00: 2:00 – 2:30: 3:45 – 4:15: 4:15- 4:45: 4:45 – 5:15: Symposium on Phylogenetic Approaches to Innate Immunity INSTITUTE OF MEDICINE - FORUM ON MICROBIAL THREATS 2-3 December 2014 DAY TWO: WEDNESDAY, DECEMBER 3, 2014 8:30 – 9:00: 9:00 – 9:15: Registration and Continental Breakfast Summary of Day One - Dr. David Relman SESSION III: INNATE IMMUNITY IN VERTEBRATE SPECIES Moderator: Stanley Lemon 9:15 – 9:45: Innate and intrinsic immunity against viruses in yeast, Drosophila, and primates Harmit Malik, University of Washington 9:45 – 10:15: Defining human innate immune diversity Sam Miller, University of Washington 10:15 – 10:45: Mucosal innate immunity in the human gut Andreas Baumler, UC Davis 10:45 – 11:00: BREAK 11:00 – 11:30: Innate immune regulation of sensitization to dietary antigens by the commensal microbiota Cathryn Nagler, University of Chicago 11:30 – 12:00: The influence of micronutrients on innate immunity Robert Modlin, UC Los Angeles 12:00 – 12:45: DISCUSSION 12:45 – 1:00: CLOSING REMARKS & ADJOURNMENT