Neurology Volume 68, Number 4, January 23, 2007 www.neurology.org 248 January 23 Highlight and Commentary: Using tPA for acute stroke in a rural setting Patrick D. Lyden 250 Of seizure prediction, statistics, and dogs: A cautionary tail Brian Litt and Abba Krieger 252 The fourth dimension of stereotaxis: Timing of neurosurgery for Parkinson disease David Riley and Andres Lozano Views and Reviews Image-guided, direct convective delivery of glucocerebrosidase for neuronopathic Gaucher disease R.R. Lonser, R. Schiffman, R.A. Robison, J.A. Butman, Z. Quezado, M.L. Walker, P.F. Morrison, S. Walbridge, G.J. Murray, D.M. Park, R.O. Brady, and E.H. Oldfield Articles 262 283 Soluble Nogo-A, an inhibitor of axonal regeneration, as a biomarker for multiple sclerosis A. Jurewicz, M. Matysiak, C.S. Raine, and K. Selmaj 288 Conversion from subtypes of mild cognitive impairment to Alzheimer dementia P. Fischer, S. Jungwirth, S. Zehetmayer, S. Weissgram, S. Hoenigschnabl, E. Gelpi, W. Krampla, and K.H. Tragl 292 Using tPA for acute stroke in a rural setting Lorraine L. Edwards 295 Muscle coenzyme Q10 deficiencies in ataxia with oculomotor apraxia 1 I. Le Ber, O. Dubourg, J.-F. Benoist, C. Jardel, F. Mochel, M. Koenig, A. Brice, A. Lombès, and A. Dürr 298 Tuberculous cranial pachymeningitis M.J. Thurtell, A.B.R. Keed, M. Yan, T. Gottlieb, J.M. Spies, and G.M. Halmagyi 301 Pathologic gambling in patients with restless legs syndrome treated with dopaminergic agonists M. Tippmann-Peikert, J.G. Park, B.F. Boeve, J.W. Shepard, and M.H. Silber January 23 Highlights Editorials 254 Official Journal of the American Academy of Neurology www.aan.com In This Issue 247 ® Can patients with epilepsy predict their seizures? S.R. Haut, C.B. Hall, A.J. LeValley, and R.B. Lipton CME Neurosurgery at an earlier stage of Parkinson disease: A randomized, controlled trial W. Schüpbach, D. Maltête, J.L. Houeto, CME S. Tezenas du Montcel, L. Mallet, M.L. Welter, M. Gargiulo, C. Béhar, A.M. Bonnet, V. Czernecki, B. Pidoux, S. Navarro, D. Dormont, P. Cornu, and Y. Agid Contemporary Issues 304 Late recovery from the minimally conscious state: Ethical and policy implications J.J. Fins, N.D. Schiff, and K.M. Foley Clinical/Scientific Notes 308 Pseudoseizure dogs G.L. Krauss, J.S. Choi, and R.P. Lesser 309 Wag the dog: Skepticism on seizure alert canines M.J. Doherty and A.M. Haltiner 310 Tiagabine-induced myoclonic status epilepticus in a nonepileptic patient C. Vollmar and S. Noachtar 267 272 277 Randomized, blind, controlled trial of transdermal rotigotine in early Parkinson disease R.L. Watts, J. Jankovic, C. Waters, A. Rajput, B. Boroojerdi, and J. Rao Expression of CD28-related costimulatory molecule and its ligand in inflammatory neuropathies W. Hu, A. Janke, S. Ortler, H.-P. Hartung, C. Leder, B.C. Kieseier, and H. Wiendl VIDEO Correspondence 311 Multiple sclerosis frequency in Israel’s diverse populations To the Editor: Klaus Lauer. Reply from the Authors: M. Alter, E. Kahana, N. Zilber, and A. Miller Continued January 23, 2007 NEUROLOGY 68 Contents 311 312 Decreasing incidence of lacunar vs other types of cerebral infarction in a Japanese population To the Editors: A. Tuttolomondo, A. Pinto, D. Di Raimondo, P. Fernandez, and G. Licata. Reply from the Authors: M. Kubo, T. Ninomiya, Y. Tanizaki, and Y. Kiyohara 303 Terminating artificial nutrition and hydration in persistent vegetative state patients: Current and proposed state laws To the Editor: Calixto Machado. Reply from the Authors: D.G. Larriviere and R.J. Bonnie E2 An unusual case of pulsatile tinnitus and deafness B. Thomas and C. Kesavadas Patient Page Understanding seizure dogs David C. Spencer Departments In the Next Issue 245 Calendar 316 314 Books Received 39A Professional Notices 48A Index to Advertisers In the Next Issue NeuroImages 294 Aneurysmal frontal bone cyst A. Torres, J.J. Acebes, J.A. Narvaez, and S. 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