HEPATOCELLULAR CARCINOMA BY THE NUMBERS Hepatocellular carcinoma (HCC) is the most common form of advanced liver cancer. It arises from a tumor in liver cells called hepatocytes. Comprises 9 in every 10 cases of liver cancer. INCIDENCE AND MORTALITY 6th 2nd most common cancer most frequent cause of cancer-related death worldwide worldwide Approximately 700,000 people around the world are diagnosed with HCC each year Nearly 1 in 12 cancer deaths is due to HCC HEPATITIS INFECTION CAUSES UP TO 90% OF HCC CASES Either the hepatitis B virus (HBV) or hepatitis C virus (HCV) OTHER RISK FACTORS INCLUDE: HBV or HCV plus excessive alcohol use Exposure to aflatoxins, a fungus known to contaminate certain crops Obesity Diabetes GLOBAL FREQUENCY OF NEW CASES OF HCC AGE-STANDARDIZED INCIDENCE RATES Cases per 100,000 Less than 2.5 2.5 to 4.9 5 to 9.9 10 to 19.9 Greater than 19.9 Highest rates of HCC in HCV most frequent cause of HCC in U.S. and Southeast Asia and sub-Saharan Africa Southern Europe due to HBV HCC INCIDENCE RATES VARY BY GENDER, AGE AND GEOGRAPHY The average age at diagnosis is about 63 in the United Men are more than twice as likely States. Liver cancer is more common in sub-Saharan Africa and Southeast Asia. as women to be diagnosed with HCC 498,000 205,000 cases per year cases per year PROGNOSIS/SURVIVAL Five-year survival rates vary depending on the stage (how far HCC has spread) and whether a patient is a candidate for a potentially curative treatment, such as surgery or transplant. FIVE YEAR SURVIVAL RATES 28% Early-stage Advanced-stage 2% *U.S. Survival Data HCC RESOURCES While research is ongoing, there are many resources available to help patients with HCC learn more about the disease, find clinical trials, and connect with other liver cancer patients: American Cancer Society: www.cancer.org American Liver Foundation: www.liverfoundation.org American Society of Clinical Oncology: www.asco.org Cancer Care: www.cancercare.org Cancer Research Institute: www.cancerresearch.org Cancer Support Community: www.cancersupportcommunity.org ClinicalTrials.gov: www.clinicaltrials.gov Hepatitis B Foundation: www.hepb.org/professionals/hepb_and_liver_cancer.htm Hepatitis C Association: www.hepcassoc.org International Society of Nurses in Cancer Care: www.isncc.org Men’s Health Network: www.menshealthnetwork.org National Cancer Institute: www.cancer.gov National Comprehensive Cancer Network: www.nccn.org Stand Up to Cancer: www.standup2cancer.org Stupid Cancer: www.stupidcancer.org Union for International Cancer Control - www.uicc.org © 2015 Bristol-Myers Squibb Company