JASN February 2015 Vol. 26 No. 2 Journal of the American Society of Nephrology Suzuki, Takayasu Kobayashi, Yoichi Suzuki, Tomohiro Nakayama, Yasuhiro Takeshima, Norma Vazquez, Sadayoshi Ito, Gerardo Gamba, and Takaaki Abe This Month’s Highlights UP FRONT MATTERS 237 Editorials The Dominant Humoral Epitope in Phospholipase A2 Receptor-1: Presentation Matters When Serving Up a Slice of p 281 Chiao-Yin Sun, Guang-Huar Young, Yu-Ting Hsieh, Yau-Hung Chen, Mai-Szu Wu, Vin-Cent Wu, Jia-Hung Lee, and Chin-Chan Lee Laurence H. Beck Jr. · 239 See related articles by Kao et al. (pp. 291–301); and Fresquet et al. (pp. 302–313). A Breath of Fresh Air for Diabetic Nephropathy Volker H. Haase · 241 BASIC RESEARCH 291 See related article by Nordquist et al. (pp. 328–338). Timing of Arteriovenous Fistula Placement: Keeping It in Perspective 243 · See related article by Hod et al. (pp. 448–456). Arteriosclerosis, Bone Biology, and Calciotropic Hormone Signaling: Learning the ABCs of Disease in the Bone-Vascular Axis 302 247 See related article by London et al. (pp. 476–483). Brief Reviews New Insights on the Risk for Cardiovascular Disease in African Americans: The Role of Added Sugars Karim R. Saab, Jessica Kendrick, Joseph M. Yracheta, Miguel A. Lanaspa, Maisha Pollard, and Richard J. Johnson 258 314 Exonic Mutations in the SLC12A3 Gene Cause Exon Skipping and Premature Termination in Gitelman Syndrome Yoichi Takeuchi, Eikan Mishima, Hisato Shima, Yasutoshi Akiyama, Chitose Suzuki, Takehiro Red star . indicates articles that are features in This Month’s Highlights. See related editorial by Beck (pp. 237–239). GIV/Girdin Links Vascular Endothelial Growth Factor Signaling to Akt Survival Signaling in Podocytes Independent of Nephrin Honghui Wang, Taro Misaki, Vanessa Taupin, Akiko Eguchi, Pradipta Ghosh, and Marilyn G. Farquhar Wilhelm Kriz and Kevin V. Lemley 271 Identiﬁcation of a Major Epitope Recognized by PLA2R Autoantibodies in Primary Membranous Nephropathy · A Potential Role for Mechanical Forces in the Detachment of Podocytes and the Progression of CKD BRIEF COMMUNICATIONS See related editorial by Beck (pp. 237–239). Maryline Fresquet, Thomas A. Jowitt, Jennet Gummadova, Richard Collins, Ronan O’Cualain, Edward A. McKenzie, Rachel Lennon, and Paul E. Brenchley Dwight A. Towler · Identiﬁcation of the Immunodominant Epitope Region in Phospholipase A2 Receptor-Mediating Autoantibody Binding in Idiopathic Membranous Nephropathy Liyo Kao, Vinson Lam, Meryl Waldman, Richard J. Glassock, and Quansheng Zhu Bradley S. Dixon · Protein-Bound Uremic Toxins Induce Tissue Remodeling by Targeting the EGF Receptor 328 Activation of Hypoxia-Inducible Factors Prevents Diabetic Nephropathy Lina Nordquist, Malou Friederich-Persson, Angelica Fasching, Per Liss, Kumi Shoji, Masaomi Nangaku, Peter Hansell, and Fredrik Palm · See related editorial by Haase (pp. 239–241). 339 Localization of APOL1 Protein and mRNA in the Human Kidney: Nondiseased Tissue, Primary Cells, and Immortalized Cell Lines Lijun Ma, Gregory S. Shelness, James A. Snipes, Mariana Murea, Peter A. Antinozzi, Dongmei Cheng, Moin A. Saleem, Simon C. Satchell, Bernhard Banas, Peter W. Mathieson, Matthias Kretzler, Ashok K. Hemal, Lawrence L. Rudel, Snezana Petrovic, Allison Weckerle, Martin R. Pollak, Michael D. Ross, John S. Parks, and Barry I. Freedman 349 379 CLINICAL EPIDEMIOLOGY 439 448 · 457 .Colony-Stimulating Factor-1: A Potential Biomarker for Lupus Nephritis Dysregulation of Autoantigen Genes in ANCAAssociated Vasculitis Involves Alternative Transcripts and New Protein Synthesis 476 Ankle-Brachial Index and Bone Turnover in Patients on Dialysis Gérard M. London, Sylvain J. Marchais, Alain P. Guérin, and Marie-Christine de Vernejoul Ya Su, Raﬁa S. Al-Lamki, Katherine G. Blake-Palmer, Alison Best, Zoe J. Golder, Aiwu Zhou, and Fiona E. Karet Frankl · 484 Adrian Schreiber, Friedrich C. Luft, and Ralph Kettritz .Indomethacin, Amiloride, or Eplerenone for Treating Hypokalemia in Gitelman Syndrome Anne Blanchard, Rosa Vargas-Poussou, Marion Vallet, Aurore Caumont-Prim, Julien Allard, Estelle Desport, Laurence Dubourg, Matthieu Monge, Damien Bergerot, Stéphanie Baron, Marie Essig, Frank Bridoux, Ivan Tack, and Michel Azizi Physical and Functional Links between Anion Exchanger-1 and Sodium Pump .Phagocyte NADPH Oxidase Restrains the Inﬂammasome in ANCA-Induced GN .Detection of C3d-Binding Donor-Speciﬁc AntiHLA Antibodies at Diagnosis of Humoral Rejection Predicts Renal Graft Loss Antoine Sicard, Stéphanie Ducreux, Maud Rabeyrin, Lionel Couzi, Brigitte McGregor, Lionel Badet, Jean Yves Scoazec, Thomas Bachelet, Sébastien Lepreux, Jonathan Visentin, Pierre Merville, Véronique Fremeaux-Bacchi, Emmanuel Morelon, Jean-Luc Taupin, Valérie Dubois, and Olivier Thaunat Elizabeth A. McInnis, Anshul K. Badhwar, Akhil Muthigi, Olivier M. Lardinois, S. Colby Allred, Jiajin Yang, Meghan E. Free, J. Charles Jennette, Gloria A. Preston, Ronald J. Falk, and Dominic J. Ciavatta 411 See related editorial by Dixon (pp. 241–243). CLINICAL RESEARCH 468 400 Arteriovenous Fistula Placement in the Elderly: When Is the Optimal Time? Tammy Hod, Bhanu K. Patibandla, Yael Vin, Robert S. Brown, and Alexander S. Goldfarb-Rumyantzev Julia Menke, Kerstin Amann, Lorenzo Cavagna, Maria Blettner, Arndt Weinmann, Andreas Schwarting, and Vicki R. Kelley 390 Subclinical Atherosclerosis Measures for Cardiovascular Prediction in CKD Kunihiro Matsushita, Yingying Sang, Shoshana H. Ballew, Michael Shlipak, Ronit Katz, Sylvia E. Rosas, Carmen A. Peralta, Mark Woodward, Holly J. Kramer, David R. Jacobs, Mark J. Sarnak, and Josef Coresh Stanniocalcin-1 Inhibits Renal Ischemia/ Reperfusion Injury via an AMP-Activated Protein Kinase-Dependent Pathway Jenny Szu-Chin Pan, Luping Huang, Tatiana Belousova, Lianghao Lu, Yongjie Yang, Roger Reddel, Andy Chang, Huiming Ju, Gabriel DiMattia, Qiang Tong, and David Sheikh-Hamad Mechanisms of Renal Control of Potassium Homeostasis in Complete Aldosterone Deﬁciency Abhijeet Todkar, Nicolas Picard, Dominique LofﬁngCueni, Mads V. Sorensen, Marija Mihailova, Viatcheslav Nesterov, Natalia Makhanova, Christoph Korbmacher, Carsten A. Wagner, and Johannes Lofﬁng .Renal F4/80+CD11c+ Mononuclear Phagocytes Display Phenotypic and Functional Characteristics of Macrophages in Health and in Adriamycin Nephropathy Qi Cao, Yiping Wang, Xin Maggie Wang, Junyu Lu, Vincent W.S. Lee, Qianling Ye, Hanh Nguyen, Guoping Zheng, Ye Zhao, Stephen I. Alexander, and David C.H. Harris 364 425 See related editorial by Towler (pp. 243–245). .HDL Cholesterol, Apolipoproteins, and Cardiovascular Risk in Hemodialysis Patients G€ unther Silbernagel, Bernd Genser, Christiane Drechsler, Hubert Scharnagl, Tanja B. Grammer, Tatjana Stojakovic, Vera Krane, Eberhard Ritz, Christoph Wanner, and Winfried März 493 Ferric Citrate Controls Phosphorus and Delivers Iron in Patients on Dialysis Julia B. Lewis, Mohammed Sika, Mark J. Koury, Peale Chuang, Gerald Schulman, Mark T. Smith, Frederick C. Whittier, Douglas R. Linfert, Claude M. Galphin, Balaji P. Athreya, A. Kaldun Kaldun Nossuli, Ingrid J. Chang, Samuel S. Blumenthal, John Manley, Steven Zeig, Kotagal S. Kant, Juan Jose Olivero, Tom Greene, and Jamie P. Dwyer, for the Collaborative Study Group